Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro

S. S. Choi, Y. Kim, K. S. Han, Seungkwon You, S. Oh, Sae Hun Kim

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Aims: The objective of this study was to assess in vitro, whether heat-killed (HK) lactic acid bacteria cells and fractionations of HK cells could suppress the viability of human cancer cells and inhibit the cytotoxicity associated with oxidative stress. Methods and Results: Among the strains, the HK cells of Lactobacillus acidophilus 606 and Lactobacillus casei ATCC 393 exhibited the most profound inhibitory activity in all of the tested cell lines. HK cells of L. acidophilus 606 were determined to be less toxic to healthy human embryo fibroblasts (hEF cells) than were HK cells of L. casei ATCC 393. The soluble polysaccharides from L. acidophilus 606 evidenced the most effective anticancer activity, but inhibited hEF cell growth by only 20%. The soluble polysaccharides from L. acidophilus 606 were partly observed to induce apoptosis in the HT-29 cells by DNA fragmentation and propidium iodine staining. Both the HK cells of L. acidophilus 606 and the soluble polysaccharide components of this strain also exhibited potent antioxidative activity. Conclusions: Our findings suggest that the soluble polysaccharide fraction from L. acidophilus 606 may constitute a novel anticancer agent, which manifests a high degree of selectivity for human cancer cells and antioxidative agent in the food industry. Significance and Impact of the Study: These soluble polysaccharide components from Lactobacillus may be applied to various foods, and used as adjuncts for cancer therapy and prevention.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalLetters in Applied Microbiology
Volume42
Issue number5
DOIs
Publication statusPublished - 2006 May 1

Fingerprint

Oxidative stress
Cell proliferation
Lactobacillus
polysaccharide
Lactobacillus acidophilus
Polysaccharides
cancer
Oxidative Stress
Cell Proliferation
Hot Temperature
Neoplasms
Cells
Lactobacillus casei
food industry
apoptosis
iodine
Propidium
Poisons
Cell growth
Cell death

Keywords

  • Anticancer
  • Apoptosis
  • Heat-killed (HK) cells
  • Lactobacillus
  • Oxidative stress
  • Soluble polysaccharide

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Water Science and Technology
  • Fluid Flow and Transfer Processes
  • Microbiology
  • Ecology

Cite this

Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro. / Choi, S. S.; Kim, Y.; Han, K. S.; You, Seungkwon; Oh, S.; Kim, Sae Hun.

In: Letters in Applied Microbiology, Vol. 42, No. 5, 01.05.2006, p. 452-458.

Research output: Contribution to journalArticle

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