Effects of lamotrigine on cognition and behavior compared to carbamazepine as monotherapy for children with partial epilepsy

So-Hee Eun, Baik-Lin Eun, Joon Soo Lee, Yong Seung Hwang, Ki Joong Kim, Young Mock Lee, In Goo Lee, Munhyang Lee, Tae Sung Ko, Jeong Tae Kim, Soyong Eom, Heung Dong Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To compare the cognitive and behavioral effects of lamotrigine (LTG) to carbamazepine (CBZ) as monotherapy for pediatric epilepsy. A multicenter, randomized, open-label, parallel-group clinical trial was conducted in children with partial-onset seizures. LTG or CBZ was prescribed as monotherapy for previously untreated children and titrated over 8. weeks, followed by maintenance for 24. weeks. Outcome measures were change in cognition and behavior in a combined analysis of standardized measures from screening to the end of the maintenance phase, as well as antiepileptic efficacy and tolerability. A total of 67 children completed the study, including 32 of 43 (74.4%) treated with LTG and 35 of 41 (85.4%) treated with CBZ. Seizure-free outcomes did not differ between the intent-to-treat populations (53.5% LTG, 56.1% CBZ; p= 0.81). There were no statistically significant differences in the intelligence of the two groups after treatment. Externalizing behavior problems improved in the CBZ group (p< 0.05). However, there were no significant differences between the two groups in terms of externalizing behavior. The parents' report on the Conner scale showed an improvement in the CBZ group compared to the LTG group (p< 0.05). LTG and CBZ showed similar efficacy and cognitive effects in treating childhood partial epilepsy. However, CBZ showed more benefits in improving externalizing behaviors.

Original languageEnglish
Pages (from-to)818-823
Number of pages6
JournalBrain and Development
Volume34
Issue number10
DOIs
Publication statusPublished - 2012 Nov 1

Fingerprint

Partial Epilepsy
Carbamazepine
Cognition
Seizures
Maintenance
lamotrigine
Intelligence
Anticonvulsants
Epilepsy
Parents
Outcome Assessment (Health Care)
Clinical Trials
Pediatrics

Keywords

  • Behavior
  • Child
  • Cognition
  • Lamotrigine
  • Partial epilepsy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Effects of lamotrigine on cognition and behavior compared to carbamazepine as monotherapy for children with partial epilepsy. / Eun, So-Hee; Eun, Baik-Lin; Lee, Joon Soo; Hwang, Yong Seung; Kim, Ki Joong; Lee, Young Mock; Lee, In Goo; Lee, Munhyang; Ko, Tae Sung; Kim, Jeong Tae; Eom, Soyong; Kim, Heung Dong.

In: Brain and Development, Vol. 34, No. 10, 01.11.2012, p. 818-823.

Research output: Contribution to journalArticle

Eun, So-Hee ; Eun, Baik-Lin ; Lee, Joon Soo ; Hwang, Yong Seung ; Kim, Ki Joong ; Lee, Young Mock ; Lee, In Goo ; Lee, Munhyang ; Ko, Tae Sung ; Kim, Jeong Tae ; Eom, Soyong ; Kim, Heung Dong. / Effects of lamotrigine on cognition and behavior compared to carbamazepine as monotherapy for children with partial epilepsy. In: Brain and Development. 2012 ; Vol. 34, No. 10. pp. 818-823.
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