Effects of lifetime cumulative ginseng intake on cognitive function in late life

Silvia Kyungjin Lho, Tae Hui Kim, Kyung Phil Kwak, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Kim, Seok Woo Moon, Jae Young Park, Joon Hyuk Park, Seonjeong Byun, Seung Wan Suh, Ji Young Seo, Yoonseop So, Seung Ho Ryu, Jong Chul Youn, Kyoung Hwan Lee, Dong Young Lee, Dong Woo LeeSeok Bum Lee, Jung Jae Lee, Ju Ri Lee, Hyeon Jeong, Hyun-Ghang Jeong, Jin Hyeong Jhoo, Kyuhee Han, Jong Woo Hong, Ji Won Han, Ki Woong Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-dwelling population-based prospective cohort of Korean elders. Methods: Community-dwelling elders (N = 6422; mean age = 70.2 ± 6.9 years, education = 8.0 ± 5.3 years, female = 56.8%) from the Korean Longitudinal Study on Cognitive Aging and Dementia were included. Among them, 3918 participants (61.0%) completed the 2-year and 4-year follow-up evaluations. Subjects were categorized according to cumulative ginseng intake at baseline evaluation; no use group, low use (< 5 years) group, and high use (≥ 5 years) group. One-way analysis of covariance (ANCOVA) was conducted to compare the impact of cumulative ginseng intake on baseline Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet neuropsychological battery total score (CERAD total score) and Mini-Mental State Examination (MMSE) score among the three groups while adjusting for potential covariates. A repeated-measures ANCOVA was performed to investigate the impacts on the changes in CERAD total scores and MMSE scores during the 4 years of follow-up. Results: The high use group showed higher CERAD total scores compared to the no use group after controlling for age, sex, education years, socioeconomic status, smoking, alcohol intake, presence of hypertension, stroke history, Geriatric Depression Scale, Cumulative Illness Rating Scale, and presence of the APOE e4 allele (F(2, 4762) = 3.978, p = 0.019). The changes of CERAD total score for 2 or 4 years of follow-up did not differ according to the use of ginseng. Conclusions: Cumulative ginseng use for longer than 5 years may be beneficial to cognitive function in late life.

Original languageEnglish
Article number50
JournalAlzheimer's Research and Therapy
Volume10
Issue number1
DOIs
Publication statusPublished - 2018 May 24

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Panax
Cognition
Independent Living
Sex Education
Social Class
Geriatrics
Longitudinal Studies
Dementia
Registries
Alzheimer Disease
Smoking
Stroke
Alleles
Alcohols
Depression
Hypertension
Education
Population

Keywords

  • Aged
  • Cognition
  • Cohort studies
  • Ginseng
  • Longitudinal studies
  • Panax

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Lho, S. K., Kim, T. H., Kwak, K. P., Kim, K., Kim, B. J., Kim, S. G., ... Kim, K. W. (2018). Effects of lifetime cumulative ginseng intake on cognitive function in late life. Alzheimer's Research and Therapy, 10(1), [50]. https://doi.org/10.1186/s13195-018-0380-0

Effects of lifetime cumulative ginseng intake on cognitive function in late life. / Lho, Silvia Kyungjin; Kim, Tae Hui; Kwak, Kyung Phil; Kim, Kayoung; Kim, Bong Jo; Kim, Shin Gyeom; Kim, Jeong Lan; Kim, Tae Hyun; Moon, Seok Woo; Park, Jae Young; Park, Joon Hyuk; Byun, Seonjeong; Suh, Seung Wan; Seo, Ji Young; So, Yoonseop; Ryu, Seung Ho; Youn, Jong Chul; Lee, Kyoung Hwan; Lee, Dong Young; Lee, Dong Woo; Lee, Seok Bum; Lee, Jung Jae; Lee, Ju Ri; Jeong, Hyeon; Jeong, Hyun-Ghang; Jhoo, Jin Hyeong; Han, Kyuhee; Hong, Jong Woo; Han, Ji Won; Kim, Ki Woong.

In: Alzheimer's Research and Therapy, Vol. 10, No. 1, 50, 24.05.2018.

Research output: Contribution to journalArticle

Lho, SK, Kim, TH, Kwak, KP, Kim, K, Kim, BJ, Kim, SG, Kim, JL, Kim, TH, Moon, SW, Park, JY, Park, JH, Byun, S, Suh, SW, Seo, JY, So, Y, Ryu, SH, Youn, JC, Lee, KH, Lee, DY, Lee, DW, Lee, SB, Lee, JJ, Lee, JR, Jeong, H, Jeong, H-G, Jhoo, JH, Han, K, Hong, JW, Han, JW & Kim, KW 2018, 'Effects of lifetime cumulative ginseng intake on cognitive function in late life', Alzheimer's Research and Therapy, vol. 10, no. 1, 50. https://doi.org/10.1186/s13195-018-0380-0
Lho, Silvia Kyungjin ; Kim, Tae Hui ; Kwak, Kyung Phil ; Kim, Kayoung ; Kim, Bong Jo ; Kim, Shin Gyeom ; Kim, Jeong Lan ; Kim, Tae Hyun ; Moon, Seok Woo ; Park, Jae Young ; Park, Joon Hyuk ; Byun, Seonjeong ; Suh, Seung Wan ; Seo, Ji Young ; So, Yoonseop ; Ryu, Seung Ho ; Youn, Jong Chul ; Lee, Kyoung Hwan ; Lee, Dong Young ; Lee, Dong Woo ; Lee, Seok Bum ; Lee, Jung Jae ; Lee, Ju Ri ; Jeong, Hyeon ; Jeong, Hyun-Ghang ; Jhoo, Jin Hyeong ; Han, Kyuhee ; Hong, Jong Woo ; Han, Ji Won ; Kim, Ki Woong. / Effects of lifetime cumulative ginseng intake on cognitive function in late life. In: Alzheimer's Research and Therapy. 2018 ; Vol. 10, No. 1.
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abstract = "Background: We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-dwelling population-based prospective cohort of Korean elders. Methods: Community-dwelling elders (N = 6422; mean age = 70.2 ± 6.9 years, education = 8.0 ± 5.3 years, female = 56.8{\%}) from the Korean Longitudinal Study on Cognitive Aging and Dementia were included. Among them, 3918 participants (61.0{\%}) completed the 2-year and 4-year follow-up evaluations. Subjects were categorized according to cumulative ginseng intake at baseline evaluation; no use group, low use (< 5 years) group, and high use (≥ 5 years) group. One-way analysis of covariance (ANCOVA) was conducted to compare the impact of cumulative ginseng intake on baseline Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet neuropsychological battery total score (CERAD total score) and Mini-Mental State Examination (MMSE) score among the three groups while adjusting for potential covariates. A repeated-measures ANCOVA was performed to investigate the impacts on the changes in CERAD total scores and MMSE scores during the 4 years of follow-up. Results: The high use group showed higher CERAD total scores compared to the no use group after controlling for age, sex, education years, socioeconomic status, smoking, alcohol intake, presence of hypertension, stroke history, Geriatric Depression Scale, Cumulative Illness Rating Scale, and presence of the APOE e4 allele (F(2, 4762) = 3.978, p = 0.019). The changes of CERAD total score for 2 or 4 years of follow-up did not differ according to the use of ginseng. Conclusions: Cumulative ginseng use for longer than 5 years may be beneficial to cognitive function in late life.",
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AU - Lho, Silvia Kyungjin

AU - Kim, Tae Hui

AU - Kwak, Kyung Phil

AU - Kim, Kayoung

AU - Kim, Bong Jo

AU - Kim, Shin Gyeom

AU - Kim, Jeong Lan

AU - Kim, Tae Hyun

AU - Moon, Seok Woo

AU - Park, Jae Young

AU - Park, Joon Hyuk

AU - Byun, Seonjeong

AU - Suh, Seung Wan

AU - Seo, Ji Young

AU - So, Yoonseop

AU - Ryu, Seung Ho

AU - Youn, Jong Chul

AU - Lee, Kyoung Hwan

AU - Lee, Dong Young

AU - Lee, Dong Woo

AU - Lee, Seok Bum

AU - Lee, Jung Jae

AU - Lee, Ju Ri

AU - Jeong, Hyeon

AU - Jeong, Hyun-Ghang

AU - Jhoo, Jin Hyeong

AU - Han, Kyuhee

AU - Hong, Jong Woo

AU - Han, Ji Won

AU - Kim, Ki Woong

PY - 2018/5/24

Y1 - 2018/5/24

N2 - Background: We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-dwelling population-based prospective cohort of Korean elders. Methods: Community-dwelling elders (N = 6422; mean age = 70.2 ± 6.9 years, education = 8.0 ± 5.3 years, female = 56.8%) from the Korean Longitudinal Study on Cognitive Aging and Dementia were included. Among them, 3918 participants (61.0%) completed the 2-year and 4-year follow-up evaluations. Subjects were categorized according to cumulative ginseng intake at baseline evaluation; no use group, low use (< 5 years) group, and high use (≥ 5 years) group. One-way analysis of covariance (ANCOVA) was conducted to compare the impact of cumulative ginseng intake on baseline Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet neuropsychological battery total score (CERAD total score) and Mini-Mental State Examination (MMSE) score among the three groups while adjusting for potential covariates. A repeated-measures ANCOVA was performed to investigate the impacts on the changes in CERAD total scores and MMSE scores during the 4 years of follow-up. Results: The high use group showed higher CERAD total scores compared to the no use group after controlling for age, sex, education years, socioeconomic status, smoking, alcohol intake, presence of hypertension, stroke history, Geriatric Depression Scale, Cumulative Illness Rating Scale, and presence of the APOE e4 allele (F(2, 4762) = 3.978, p = 0.019). The changes of CERAD total score for 2 or 4 years of follow-up did not differ according to the use of ginseng. Conclusions: Cumulative ginseng use for longer than 5 years may be beneficial to cognitive function in late life.

AB - Background: We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-dwelling population-based prospective cohort of Korean elders. Methods: Community-dwelling elders (N = 6422; mean age = 70.2 ± 6.9 years, education = 8.0 ± 5.3 years, female = 56.8%) from the Korean Longitudinal Study on Cognitive Aging and Dementia were included. Among them, 3918 participants (61.0%) completed the 2-year and 4-year follow-up evaluations. Subjects were categorized according to cumulative ginseng intake at baseline evaluation; no use group, low use (< 5 years) group, and high use (≥ 5 years) group. One-way analysis of covariance (ANCOVA) was conducted to compare the impact of cumulative ginseng intake on baseline Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet neuropsychological battery total score (CERAD total score) and Mini-Mental State Examination (MMSE) score among the three groups while adjusting for potential covariates. A repeated-measures ANCOVA was performed to investigate the impacts on the changes in CERAD total scores and MMSE scores during the 4 years of follow-up. Results: The high use group showed higher CERAD total scores compared to the no use group after controlling for age, sex, education years, socioeconomic status, smoking, alcohol intake, presence of hypertension, stroke history, Geriatric Depression Scale, Cumulative Illness Rating Scale, and presence of the APOE e4 allele (F(2, 4762) = 3.978, p = 0.019). The changes of CERAD total score for 2 or 4 years of follow-up did not differ according to the use of ginseng. Conclusions: Cumulative ginseng use for longer than 5 years may be beneficial to cognitive function in late life.

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KW - Longitudinal studies

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