Effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia

Sin Wook Kim, Wan Cheol Lee, Ma Tae Kim, Kyungtae Ko, Won Ki Lee, Choong Hyun Lee, Je-Jong Kim, Dae Yul Yang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: The aim of the present study was to evaluate the effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia. Materials and Methods: A total of 138 male LUTS patients aged more than 50 years with an International Prostate Symptom Score (IPSS) ≥8 were enrolled in this open-la-bel, multicenter, prospective, noncomparative observational study. Clinical assess-ments included IPSS, quality of life (QoL) index, International Index of Erectile Function (IIEF), Danish Prostate Symptom Score (DAN-PSS), and an early morning erection questionnaire. The data were recorded at baseline and at 1 and 3 months after treatment with tamsulosin 0.2 mg/d. Adverse events were analyzed in all patients. Results: During the study period of 3 months, the IPSS and QoL index significantly improved from baseline by -11.40±9.40 and -1.11±1.36, respectively (p<0.001). However, there were no clinically relevant changes in total IIEF score (mean difference, 1.63±15.50; p=0.406) or the 5 subdomains (p>0.05). Furthermore, DAN-PSS weighted scores (A×B) showed no clinically relevant changes (mean difference on Q1, Q2, and Q3: -0.45±2.94, 0.27±2.50, and -1.27±2.27, p>0.05). In addition, there were no clin-ically significant changes in responses on the early morning erection questionnaire. Conclusions: Tamsulosin at the dose of 0.2 mg significantly improved the IPSS and the QoL index compared with baseline. However, tamsulosin did not exhibit any significant impact on sexual function or any negative impact on ejaculatory function.

Original languageEnglish
Pages (from-to)697-702
Number of pages6
JournalKorean Journal of Urology
Volume54
Issue number10
DOIs
Publication statusPublished - 2013 Oct 1

Keywords

  • Ejaculation
  • Erectile dysfunction
  • Lower urinary tract symptoms
  • Prostatic hyperplasia
  • Tamsulosin

ASJC Scopus subject areas

  • Urology

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