Abstract
Purpose: The aim of the present study was to evaluate the effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia. Materials and Methods: A total of 138 male LUTS patients aged more than 50 years with an International Prostate Symptom Score (IPSS) ≥8 were enrolled in this open-la-bel, multicenter, prospective, noncomparative observational study. Clinical assess-ments included IPSS, quality of life (QoL) index, International Index of Erectile Function (IIEF), Danish Prostate Symptom Score (DAN-PSS), and an early morning erection questionnaire. The data were recorded at baseline and at 1 and 3 months after treatment with tamsulosin 0.2 mg/d. Adverse events were analyzed in all patients. Results: During the study period of 3 months, the IPSS and QoL index significantly improved from baseline by -11.40±9.40 and -1.11±1.36, respectively (p<0.001). However, there were no clinically relevant changes in total IIEF score (mean difference, 1.63±15.50; p=0.406) or the 5 subdomains (p>0.05). Furthermore, DAN-PSS weighted scores (A×B) showed no clinically relevant changes (mean difference on Q1, Q2, and Q3: -0.45±2.94, 0.27±2.50, and -1.27±2.27, p>0.05). In addition, there were no clin-ically significant changes in responses on the early morning erection questionnaire. Conclusions: Tamsulosin at the dose of 0.2 mg significantly improved the IPSS and the QoL index compared with baseline. However, tamsulosin did not exhibit any significant impact on sexual function or any negative impact on ejaculatory function.
| Original language | English |
|---|---|
| Pages (from-to) | 697-702 |
| Number of pages | 6 |
| Journal | Korean Journal of Urology |
| Volume | 54 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2013 Oct 1 |
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Keywords
- Ejaculation
- Erectile dysfunction
- Lower urinary tract symptoms
- Prostatic hyperplasia
- Tamsulosin
ASJC Scopus subject areas
- Urology
Cite this
Effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. / Kim, Sin Wook; Lee, Wan Cheol; Kim, Ma Tae; Ko, Kyungtae; Lee, Won Ki; Lee, Choong Hyun; Kim, Je-Jong; Yang, Dae Yul.
In: Korean Journal of Urology, Vol. 54, No. 10, 01.10.2013, p. 697-702.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia
AU - Kim, Sin Wook
AU - Lee, Wan Cheol
AU - Kim, Ma Tae
AU - Ko, Kyungtae
AU - Lee, Won Ki
AU - Lee, Choong Hyun
AU - Kim, Je-Jong
AU - Yang, Dae Yul
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Purpose: The aim of the present study was to evaluate the effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia. Materials and Methods: A total of 138 male LUTS patients aged more than 50 years with an International Prostate Symptom Score (IPSS) ≥8 were enrolled in this open-la-bel, multicenter, prospective, noncomparative observational study. Clinical assess-ments included IPSS, quality of life (QoL) index, International Index of Erectile Function (IIEF), Danish Prostate Symptom Score (DAN-PSS), and an early morning erection questionnaire. The data were recorded at baseline and at 1 and 3 months after treatment with tamsulosin 0.2 mg/d. Adverse events were analyzed in all patients. Results: During the study period of 3 months, the IPSS and QoL index significantly improved from baseline by -11.40±9.40 and -1.11±1.36, respectively (p<0.001). However, there were no clinically relevant changes in total IIEF score (mean difference, 1.63±15.50; p=0.406) or the 5 subdomains (p>0.05). Furthermore, DAN-PSS weighted scores (A×B) showed no clinically relevant changes (mean difference on Q1, Q2, and Q3: -0.45±2.94, 0.27±2.50, and -1.27±2.27, p>0.05). In addition, there were no clin-ically significant changes in responses on the early morning erection questionnaire. Conclusions: Tamsulosin at the dose of 0.2 mg significantly improved the IPSS and the QoL index compared with baseline. However, tamsulosin did not exhibit any significant impact on sexual function or any negative impact on ejaculatory function.
AB - Purpose: The aim of the present study was to evaluate the effects of low-dose tamsulosin on sexual function in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia. Materials and Methods: A total of 138 male LUTS patients aged more than 50 years with an International Prostate Symptom Score (IPSS) ≥8 were enrolled in this open-la-bel, multicenter, prospective, noncomparative observational study. Clinical assess-ments included IPSS, quality of life (QoL) index, International Index of Erectile Function (IIEF), Danish Prostate Symptom Score (DAN-PSS), and an early morning erection questionnaire. The data were recorded at baseline and at 1 and 3 months after treatment with tamsulosin 0.2 mg/d. Adverse events were analyzed in all patients. Results: During the study period of 3 months, the IPSS and QoL index significantly improved from baseline by -11.40±9.40 and -1.11±1.36, respectively (p<0.001). However, there were no clinically relevant changes in total IIEF score (mean difference, 1.63±15.50; p=0.406) or the 5 subdomains (p>0.05). Furthermore, DAN-PSS weighted scores (A×B) showed no clinically relevant changes (mean difference on Q1, Q2, and Q3: -0.45±2.94, 0.27±2.50, and -1.27±2.27, p>0.05). In addition, there were no clin-ically significant changes in responses on the early morning erection questionnaire. Conclusions: Tamsulosin at the dose of 0.2 mg significantly improved the IPSS and the QoL index compared with baseline. However, tamsulosin did not exhibit any significant impact on sexual function or any negative impact on ejaculatory function.
KW - Ejaculation
KW - Erectile dysfunction
KW - Lower urinary tract symptoms
KW - Prostatic hyperplasia
KW - Tamsulosin
UR - http://www.scopus.com/inward/record.url?scp=84886283152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886283152&partnerID=8YFLogxK
U2 - 10.4111/kju.2013.54.10.697
DO - 10.4111/kju.2013.54.10.697
M3 - Article
C2 - 24175045
AN - SCOPUS:84886283152
VL - 54
SP - 697
EP - 702
JO - Korean Journal of Urology
JF - Korean Journal of Urology
SN - 2005-6737
IS - 10
ER -