Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention.

Jae Suk Choi, Sung Kyu Jung, Min Hee Jeon, Jin Nam Moon, Woi Sook Moon, Yi Hwa Ji, In Soon Choi, Sang Wook Son

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To evaluate the potential hair growth-promoting activity and the expression of cell growth factors of Lycopersicon esculentum extracts, each 3% (w/w) of ethyl acetate extract (EAE), and supercritical CO2 extract (SCE) of L. esculentum and isolated lycopene Tween 80 solution (LTS) and test hair tonic (THT) containing LTS were applied on the dorsal skin of C57BL/6 mice, once a day for 4 weeks. At week 4, LTS and THT exhibited hair growth-promoting potential similar to that of 3% minoxidil as a positive control (PC). Further, in the LTS group, a significant increase of mRNA expression of vascular endothelial growth factor (VEGF), keratinocyte growth factor, and insulin-like growth factor-1 (IGF-1) was observed than PC, as well as the negative control (NC). In the THT group, increases in IGF-1 and decrease in VEGF and transforming growth factor-β expression were significant over the NC. In a histological examination in the THT group, the induction of anagen stage of hair follicles was faster than that of NC. In the Draize skin irritation study for THT, no observable edema or erythema was observed on all four sectors in the back skin after exposure for 24 or 72 h for any rabbit. Therefore, this study provides reasonable evidence that L. esculentum extracts promote hair growth and suggests that applications could be found in hair loss treatments without skin irritation at moderate doses.

Original languageEnglish
Pages (from-to)429-443
Number of pages15
JournalJournal of Cosmetic Science
Volume64
Issue number6
Publication statusPublished - 2013 Nov 1

Fingerprint

Alopecia
Lycopersicon esculentum
Hair
Polysorbates
Skin
Growth
Somatomedins
Vascular Endothelial Growth Factor A
Fibroblast Growth Factor 7
Minoxidil
Cell growth
Transforming Growth Factors
Intercellular Signaling Peptides and Proteins
Hair Follicle
Erythema
Inbred C57BL Mouse
Messenger RNA
lycopene
Edema
Rabbits

ASJC Scopus subject areas

  • Chemistry(all)
  • Dermatology

Cite this

Choi, J. S., Jung, S. K., Jeon, M. H., Moon, J. N., Moon, W. S., Ji, Y. H., ... Son, S. W. (2013). Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention. Journal of Cosmetic Science, 64(6), 429-443.

Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention. / Choi, Jae Suk; Jung, Sung Kyu; Jeon, Min Hee; Moon, Jin Nam; Moon, Woi Sook; Ji, Yi Hwa; Choi, In Soon; Son, Sang Wook.

In: Journal of Cosmetic Science, Vol. 64, No. 6, 01.11.2013, p. 429-443.

Research output: Contribution to journalArticle

Choi, JS, Jung, SK, Jeon, MH, Moon, JN, Moon, WS, Ji, YH, Choi, IS & Son, SW 2013, 'Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention.', Journal of Cosmetic Science, vol. 64, no. 6, pp. 429-443.
Choi JS, Jung SK, Jeon MH, Moon JN, Moon WS, Ji YH et al. Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention. Journal of Cosmetic Science. 2013 Nov 1;64(6):429-443.
Choi, Jae Suk ; Jung, Sung Kyu ; Jeon, Min Hee ; Moon, Jin Nam ; Moon, Woi Sook ; Ji, Yi Hwa ; Choi, In Soon ; Son, Sang Wook. / Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention. In: Journal of Cosmetic Science. 2013 ; Vol. 64, No. 6. pp. 429-443.
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