Effects of medication and deep brain stimulation on speed and amplitude are different between finger and forearm in patient with parkinson's disease

Ji Won Kim, Yuri Kwon, Yeji Ho, Sang Hoon Park, Chul Seung Kim, Gwang Moon Eom, Jae Hoon Jun, Jeong Whan Lee, Kyeong Seop Kim, Min Jik Kim, Seong Beom Koh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although differential effects of medication and deep brain stimulation (DBS) on bradykinesia have been addressed in the literature, speed and amplitude have not been separated. This study investigated the differential effects of medication and DBS on quantitative measures of speed and amplitude, as well as on proximal and distal muscles of upper extremities. Fourteen upper limbs affected by Parkinson's disease were tested. Finger tapping and forearm rotation were performed to investigate distal and proximal bradykinesia, respectively. Test conditions included off-treatment, DBS only, medication only, and medication + DBS. Quantitative outcome measures included root-mean-square average of speed and amplitude. Two-way and one-way ANOVA (analysis of variance) were performed to investigate the effects of medication and DBS, and to compare the performance in four test conditions, respectively. Speed was improved at both body parts, whereas amplitude was improved only at the proximal forearm (p < 0.01). Medication tended to be better than DBS at distal speed, whereas DBS tended to be better than medication at proximal amplitude. Medication + DBS resulted in the best average performance in all outcome measures. Improvement in speed and amplitude in each body parts are differentially associated with medication and DBS. Medication and DBS have complementary effects in amelioration of bradykinesia. The findings may be helpful for clinical interventions and evaluations.

Original languageEnglish
Pages (from-to)1201-1207
Number of pages7
JournalInternational Journal of Precision Engineering and Manufacturing
Volume14
Issue number7
DOIs
Publication statusPublished - 2013 Dec 1

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Brain
Analysis of variance (ANOVA)
Muscle

Keywords

  • Amplitude
  • Bradykinesia
  • Deep brain stimulation
  • Medication
  • Speed

ASJC Scopus subject areas

  • Mechanical Engineering
  • Industrial and Manufacturing Engineering
  • Electrical and Electronic Engineering

Cite this

Effects of medication and deep brain stimulation on speed and amplitude are different between finger and forearm in patient with parkinson's disease. / Kim, Ji Won; Kwon, Yuri; Ho, Yeji; Park, Sang Hoon; Kim, Chul Seung; Eom, Gwang Moon; Jun, Jae Hoon; Lee, Jeong Whan; Kim, Kyeong Seop; Kim, Min Jik; Koh, Seong Beom.

In: International Journal of Precision Engineering and Manufacturing, Vol. 14, No. 7, 01.12.2013, p. 1201-1207.

Research output: Contribution to journalArticle

Kim, Ji Won ; Kwon, Yuri ; Ho, Yeji ; Park, Sang Hoon ; Kim, Chul Seung ; Eom, Gwang Moon ; Jun, Jae Hoon ; Lee, Jeong Whan ; Kim, Kyeong Seop ; Kim, Min Jik ; Koh, Seong Beom. / Effects of medication and deep brain stimulation on speed and amplitude are different between finger and forearm in patient with parkinson's disease. In: International Journal of Precision Engineering and Manufacturing. 2013 ; Vol. 14, No. 7. pp. 1201-1207.
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