Effects of medication and deep brain stimulation on speed and amplitude are different between finger and forearm in patient with parkinson's disease

Ji Won Kim, Yuri Kwon, Yeji Ho, Sang Hoon Park, Chul Seung Kim, Gwang Moon Eom, Jae Hoon Jun, Jeong Whan Lee, Kyeong Seop Kim, Min Jik Kim, Seong Beom Koh

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Although differential effects of medication and deep brain stimulation (DBS) on bradykinesia have been addressed in the literature, speed and amplitude have not been separated. This study investigated the differential effects of medication and DBS on quantitative measures of speed and amplitude, as well as on proximal and distal muscles of upper extremities. Fourteen upper limbs affected by Parkinson's disease were tested. Finger tapping and forearm rotation were performed to investigate distal and proximal bradykinesia, respectively. Test conditions included off-treatment, DBS only, medication only, and medication + DBS. Quantitative outcome measures included root-mean-square average of speed and amplitude. Two-way and one-way ANOVA (analysis of variance) were performed to investigate the effects of medication and DBS, and to compare the performance in four test conditions, respectively. Speed was improved at both body parts, whereas amplitude was improved only at the proximal forearm (p < 0.01). Medication tended to be better than DBS at distal speed, whereas DBS tended to be better than medication at proximal amplitude. Medication + DBS resulted in the best average performance in all outcome measures. Improvement in speed and amplitude in each body parts are differentially associated with medication and DBS. Medication and DBS have complementary effects in amelioration of bradykinesia. The findings may be helpful for clinical interventions and evaluations.

    Original languageEnglish
    Pages (from-to)1201-1207
    Number of pages7
    JournalInternational Journal of Precision Engineering and Manufacturing
    Volume14
    Issue number7
    DOIs
    Publication statusPublished - 2013 Jul

    Keywords

    • Amplitude
    • Bradykinesia
    • Deep brain stimulation
    • Medication
    • Speed

    ASJC Scopus subject areas

    • Mechanical Engineering
    • Industrial and Manufacturing Engineering
    • Electrical and Electronic Engineering

    Fingerprint

    Dive into the research topics of 'Effects of medication and deep brain stimulation on speed and amplitude are different between finger and forearm in patient with parkinson's disease'. Together they form a unique fingerprint.

    Cite this