Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder

Moon-Soo Lee, Jae Won Yang, Young-Hoon Ko, Changsu Han, Seung Hyun Kim, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.

Original languageEnglish
Pages (from-to)201-209
Number of pages9
JournalChild Psychiatry and Human Development
Volume39
Issue number2
DOIs
Publication statusPublished - 2008 Jun 1

Fingerprint

Bupropion
Methylphenidate
Dehydroepiandrosterone
Attention Deficit Disorder with Hyperactivity
Hydrocortisone
Therapeutics

Keywords

  • Attention deficit disorder with hyperactivity
  • Bupropion
  • Dehydroepiandrosterone sulfate
  • Methylphenidate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder. / Lee, Moon-Soo; Yang, Jae Won; Ko, Young-Hoon; Han, Changsu; Kim, Seung Hyun; Lee, Min-Soo; Joe, Sook Haeng; Jung, In Kwa.

In: Child Psychiatry and Human Development, Vol. 39, No. 2, 01.06.2008, p. 201-209.

Research output: Contribution to journalArticle

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