Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder

Moon Soo Lee, Jae Won Yang, Young Hoon Ko, Changsu Han, Seung Hyun Kim, Min Soo Lee, Sook Haeng Joe, In Kwa Jung

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.

    Original languageEnglish
    Pages (from-to)201-209
    Number of pages9
    JournalChild Psychiatry and Human Development
    Volume39
    Issue number2
    DOIs
    Publication statusPublished - 2008 Jun

    Keywords

    • Attention deficit disorder with hyperactivity
    • Bupropion
    • Dehydroepiandrosterone sulfate
    • Methylphenidate

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Developmental and Educational Psychology
    • Psychiatry and Mental health

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