Effects of morphine on mechanical allodynia in a rat model of central neuropathic pain

Junesun Kim, Ji In Jung, Heung Sik Na, Seung Kil Hong, Young Wook Yoon

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We examined whether morphine reduced the behavioral signs of neuropathic pain below level induced by T13 spinal hemisection in rats. In order to examine the effect of morphine on the mechanical allodynia, morphine alone, morphine with naloxone and saline were administered intraperitoneally and intrathecally and behavioral tests were conducted. In systemic injection, mechanical allodynia was reduced only when a higher concentration of morphine (5 mg/kg) was used. Intrathecally injected morphine (0.5, 1, 2, 5 μg) reduced mechanical allodynia dose-dependently. It is suggested that systemic morphine has limited effect on mechanical allodynia but direct spinal administration of morphine is more effective in controlling central pain following spinal cord injury.

Original languageEnglish
Pages (from-to)1017-1020
Number of pages4
JournalNeuroreport
Volume14
Issue number7
DOIs
Publication statusPublished - 2003 May

Keywords

  • Allodynia
  • Morphine
  • Neuropathic pain
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

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