Effects of orally-administered bifidobacterium animalis subsp. Lactis strain bb12 on dextran sodium sulfate-induced colitis in mice

Jung Min Chae, Wan Heo, Hyung Taek Cho, Dong Hun Lee, Jun Ho Kim, Min-Suk Rhee, Tae Sik Park, Yong Ki Kim, Jin Hyup Lee, Young Jun Kim

Research output: Contribution to journalArticle

Abstract

Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis (UC), is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Intestinal epithelial cells (IECs) constitute barrier surfaces and play a critical role in maintaining gut health. Dysregulated immune responses and destruction of IECs disrupt intestinal balance. Dextran sodium sulfate (DSS) is the most widely used chemical for inducing colitis in animals, and its treatment induces colonic inflammation, acute diarrhea, and shortening of the intestine, with clinical and histological similarity to human UC. Current treatments for this inflammatory disorder have poor tolerability and insufficient therapeutic efficacy, and thus, alternative therapeutic approaches are required. Recently, dietary supplements with probiotics have emerged as promising interventions by alleviating disturbances in the indigenous microflora in UC. Thus, we hypothesized that the probiotic Bifidobacterium animalis subsp. lactis strain BB12 could protect against the development of colitis in a DSS-induced mouse model of UC. In the present study, oral administration of BB12 markedly ameliorated DSS-induced colitis, accompanied by reduced tumor necrosis factor-α-mediated IEC apoptosis. These findings indicate that the probiotic strain BB12 can alleviate DSS-induced colitis and suggest a novel mechanism of communication between probiotic microorganisms and intestinal epithelia, which increases intestinal cell survival by modulating pro-apoptotic cytokine expression.

Original languageEnglish
Pages (from-to)1800-1805
Number of pages6
JournalJournal of Microbiology and Biotechnology
Volume28
Issue number11
DOIs
Publication statusPublished - 2018 Nov 28

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Dextran Sulfate
Probiotics
Colitis
Ulcerative Colitis
Epithelial Cells
Therapeutics
Intestinal Mucosa
Dietary Supplements
Inflammatory Bowel Diseases
Crohn Disease
Intestines
Oral Administration
Gastrointestinal Tract
Diarrhea
Cell Survival
Tumor Necrosis Factor-alpha
Communication
Apoptosis
Cytokines
Inflammation

Keywords

  • Apoptosis
  • Colitis
  • Probiotics
  • TNF-α

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Effects of orally-administered bifidobacterium animalis subsp. Lactis strain bb12 on dextran sodium sulfate-induced colitis in mice. / Chae, Jung Min; Heo, Wan; Cho, Hyung Taek; Lee, Dong Hun; Kim, Jun Ho; Rhee, Min-Suk; Park, Tae Sik; Kim, Yong Ki; Lee, Jin Hyup; Kim, Young Jun.

In: Journal of Microbiology and Biotechnology, Vol. 28, No. 11, 28.11.2018, p. 1800-1805.

Research output: Contribution to journalArticle

Chae, Jung Min ; Heo, Wan ; Cho, Hyung Taek ; Lee, Dong Hun ; Kim, Jun Ho ; Rhee, Min-Suk ; Park, Tae Sik ; Kim, Yong Ki ; Lee, Jin Hyup ; Kim, Young Jun. / Effects of orally-administered bifidobacterium animalis subsp. Lactis strain bb12 on dextran sodium sulfate-induced colitis in mice. In: Journal of Microbiology and Biotechnology. 2018 ; Vol. 28, No. 11. pp. 1800-1805.
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