Effects of Oryza sativa L. aleurone layer extract on bone mineral density and bone-related markers in the ovariectomized rat

Song Yee Nam, Nam Seok Kim, Young Min Lee, Bong Kyoum Choi, Seon Hye Lee, Hwan Hee Jang, Jung Bong Kim, Hae Jeung Lee, Sung-Joon Lee, Sung Hyen Lee

Research output: Contribution to journalArticle

Abstract

Aleurone layer of Black rice (Oryza sativa L.) is enriched with anthocyanin that could increase bone density. This study was conducted to investigate the osteoporosis-preventing effects of the aleurone layer extract (BRE) on bone loss of ovariectomized (OVX) rats. OVX (or sham-operated) rats were assigned to three groups (n=8 per group): sham operated group (Sham); OVX control group (OVX); OVX-BRE group, OVX rats treated with BRE at 90 mg/kg B.W. The deionized water alone or deionized water with BRE was orally administrated to Sham, OVX or OVX-BRE groups, respectively for 12 weeks. High fat diet with 45 kcal% fat and water were fed to all rats ad libitum. Body weight was significantly decreased in the OVX-BRE group compared to the OVX group (p

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalKorean Journal of Pharmacognosy
Volume46
Issue number2
Publication statusPublished - 2015 Aug 19

Keywords

  • Aleurone layer
  • Bone mineral content
  • Bone mineral density
  • Oryza sativa L
  • Ovariectomized (OVX) rats

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

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  • Cite this

    Nam, S. Y., Kim, N. S., Lee, Y. M., Choi, B. K., Lee, S. H., Jang, H. H., Kim, J. B., Lee, H. J., Lee, S-J., & Lee, S. H. (2015). Effects of Oryza sativa L. aleurone layer extract on bone mineral density and bone-related markers in the ovariectomized rat. Korean Journal of Pharmacognosy, 46(2), 167-172.