Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs

J. M. Kim, K. T. Lee, K. S. Lim, E. W. Park, Youngsik Lee, Ki Chang Hong

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The peroxisome proliferator-activated receptor-gamma coactivator-1A (encoded by PPARGC1A) is involved in the formation of type I fibres. Therefore, the PPARGC1A gene can be considered as a functional candidate gene for muscle fibre type composition and meat quality in pigs. The aim of this study was to investigate the associations of the p.C430S polymorphic site in exon 8 of the PPARGC1A gene with muscle fibre characteristics and meat quality traits. The polymorphism was genotyped by PCR-RFLP using AluI restriction enzyme on a total of 152 Yorkshire pigs. Statistical analyses revealed that the p.C430S genotypes significantly affected number (P < 0.05) and area (P < 0.01) of type I muscle fibre, and were significantly associated with muscle pH (P < 0.001) and lightness (P < 0.01). On the basis of these results, we suggest that the p.C430S polymorphism can induce variation of type I fibre formation in porcine longissimus dorsi muscle and that it can be used as a meaningful molecular marker for better meat quality.

Original languageEnglish
Pages (from-to)642-645
Number of pages4
JournalAnimal Genetics
Volume41
Issue number6
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Yorkshire (swine breed)
muscle fibers
Meat
meat quality
Swine
genetic polymorphism
Muscles
swine
dietary fiber
Genes
muscles
genes
Slow-Twitch Muscle Fibers
longissimus muscle
exons
PPAR gamma
restriction fragment length polymorphism
Restriction Fragment Length Polymorphisms
Exons
genetic markers

Keywords

  • meat quality
  • muscle fibre type composition
  • polymorphism
  • PPARGC1A

ASJC Scopus subject areas

  • Genetics
  • Animal Science and Zoology

Cite this

Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs. / Kim, J. M.; Lee, K. T.; Lim, K. S.; Park, E. W.; Lee, Youngsik; Hong, Ki Chang.

In: Animal Genetics, Vol. 41, No. 6, 01.12.2010, p. 642-645.

Research output: Contribution to journalArticle

@article{d51bc87f9c8744ebad2ab48d67fd5f93,
title = "Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs",
abstract = "The peroxisome proliferator-activated receptor-gamma coactivator-1A (encoded by PPARGC1A) is involved in the formation of type I fibres. Therefore, the PPARGC1A gene can be considered as a functional candidate gene for muscle fibre type composition and meat quality in pigs. The aim of this study was to investigate the associations of the p.C430S polymorphic site in exon 8 of the PPARGC1A gene with muscle fibre characteristics and meat quality traits. The polymorphism was genotyped by PCR-RFLP using AluI restriction enzyme on a total of 152 Yorkshire pigs. Statistical analyses revealed that the p.C430S genotypes significantly affected number (P < 0.05) and area (P < 0.01) of type I muscle fibre, and were significantly associated with muscle pH (P < 0.001) and lightness (P < 0.01). On the basis of these results, we suggest that the p.C430S polymorphism can induce variation of type I fibre formation in porcine longissimus dorsi muscle and that it can be used as a meaningful molecular marker for better meat quality.",
keywords = "meat quality, muscle fibre type composition, polymorphism, PPARGC1A",
author = "Kim, {J. M.} and Lee, {K. T.} and Lim, {K. S.} and Park, {E. W.} and Youngsik Lee and Hong, {Ki Chang}",
year = "2010",
month = "12",
day = "1",
doi = "10.1111/j.1365-2052.2010.02042.x",
language = "English",
volume = "41",
pages = "642--645",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs

AU - Kim, J. M.

AU - Lee, K. T.

AU - Lim, K. S.

AU - Park, E. W.

AU - Lee, Youngsik

AU - Hong, Ki Chang

PY - 2010/12/1

Y1 - 2010/12/1

N2 - The peroxisome proliferator-activated receptor-gamma coactivator-1A (encoded by PPARGC1A) is involved in the formation of type I fibres. Therefore, the PPARGC1A gene can be considered as a functional candidate gene for muscle fibre type composition and meat quality in pigs. The aim of this study was to investigate the associations of the p.C430S polymorphic site in exon 8 of the PPARGC1A gene with muscle fibre characteristics and meat quality traits. The polymorphism was genotyped by PCR-RFLP using AluI restriction enzyme on a total of 152 Yorkshire pigs. Statistical analyses revealed that the p.C430S genotypes significantly affected number (P < 0.05) and area (P < 0.01) of type I muscle fibre, and were significantly associated with muscle pH (P < 0.001) and lightness (P < 0.01). On the basis of these results, we suggest that the p.C430S polymorphism can induce variation of type I fibre formation in porcine longissimus dorsi muscle and that it can be used as a meaningful molecular marker for better meat quality.

AB - The peroxisome proliferator-activated receptor-gamma coactivator-1A (encoded by PPARGC1A) is involved in the formation of type I fibres. Therefore, the PPARGC1A gene can be considered as a functional candidate gene for muscle fibre type composition and meat quality in pigs. The aim of this study was to investigate the associations of the p.C430S polymorphic site in exon 8 of the PPARGC1A gene with muscle fibre characteristics and meat quality traits. The polymorphism was genotyped by PCR-RFLP using AluI restriction enzyme on a total of 152 Yorkshire pigs. Statistical analyses revealed that the p.C430S genotypes significantly affected number (P < 0.05) and area (P < 0.01) of type I muscle fibre, and were significantly associated with muscle pH (P < 0.001) and lightness (P < 0.01). On the basis of these results, we suggest that the p.C430S polymorphism can induce variation of type I fibre formation in porcine longissimus dorsi muscle and that it can be used as a meaningful molecular marker for better meat quality.

KW - meat quality

KW - muscle fibre type composition

KW - polymorphism

KW - PPARGC1A

UR - http://www.scopus.com/inward/record.url?scp=78449271350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78449271350&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2052.2010.02042.x

DO - 10.1111/j.1365-2052.2010.02042.x

M3 - Article

C2 - 20412126

AN - SCOPUS:78449271350

VL - 41

SP - 642

EP - 645

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

IS - 6

ER -