Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs

J. M. Kim, K. T. Lee, K. S. Lim, E. W. Park, Youngsik Lee, Ki Chang Hong

Research output: Contribution to journalArticle

13 Citations (Scopus)


The peroxisome proliferator-activated receptor-gamma coactivator-1A (encoded by PPARGC1A) is involved in the formation of type I fibres. Therefore, the PPARGC1A gene can be considered as a functional candidate gene for muscle fibre type composition and meat quality in pigs. The aim of this study was to investigate the associations of the p.C430S polymorphic site in exon 8 of the PPARGC1A gene with muscle fibre characteristics and meat quality traits. The polymorphism was genotyped by PCR-RFLP using AluI restriction enzyme on a total of 152 Yorkshire pigs. Statistical analyses revealed that the p.C430S genotypes significantly affected number (P < 0.05) and area (P < 0.01) of type I muscle fibre, and were significantly associated with muscle pH (P < 0.001) and lightness (P < 0.01). On the basis of these results, we suggest that the p.C430S polymorphism can induce variation of type I fibre formation in porcine longissimus dorsi muscle and that it can be used as a meaningful molecular marker for better meat quality.

Original languageEnglish
Pages (from-to)642-645
Number of pages4
JournalAnimal Genetics
Issue number6
Publication statusPublished - 2010 Dec 1



  • meat quality
  • muscle fibre type composition
  • polymorphism

ASJC Scopus subject areas

  • Genetics
  • Animal Science and Zoology

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