Effects of perfluorooctane sulfuric acid on placental PRL-family hormone production and fetal growth retardation in mice

Chae Kwan Lee, Sung Goo Kang, Jong-Tae Lee, Soo Woong Lee, Jeong Ho Kim, Dae Hwan Kim, Byung Chul Son, Kun Hyung Kim, Chun Hui Suh, Se Yeong Kim, Yeong Beom Park

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Perfluorooctane sulfuric acid (PFOS) is a persistent organic pollutant, causes fetal growth retardation but the mechanism is still unclear. This study focused on PFOS-induced toxicity such as placental trophoblast cell histopathological changes, endocrine function (i.e., prolactin (PRL)-family hormone production) and subsequent fetal growth retardation in mice. Maternal body weight gain, placental and fetal weights were significantly decreased in proportion to PFOS dosage. Placental efficiency (fetal weight/placental weight) was significantly reduced dose-dependently. Necrotic changes were observed in PFOS-treated placental tissues, and the area of injury increased dose-dependently. Finally, mRNA levels and maternal serum concentrations of the PRL-family hormones (mPL-II, mPLP-Cα, mPLP-K) were significantly reduced dose-dependently. In addition, the changing pattern between PRL-family hormone concentrations and fetal body weight was positively correlated. These results suggest that gestational PFOS treatment induces placental histopathological changes and disruption of endocrine function, finally may lead to fetal growth retardation in mice.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalMolecular and Cellular Endocrinology
Volume401
DOIs
Publication statusPublished - 2015 Feb 5
Externally publishedYes

Fingerprint

Fetal Growth Retardation
Prolactin
Fetal Weight
Hormones
Stored Messenger RNA
Organic pollutants
Trophoblasts
Weight Gain
Toxicity
Body Weight
Mothers
perfluorooctane
sulfuric acid
Tissue
Weights and Measures
Messenger RNA
Wounds and Injuries
Serum

Keywords

  • Fetal growrh retardation
  • PFOS
  • Placenta
  • Placental lactogen
  • Prolactin-like protein

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

Effects of perfluorooctane sulfuric acid on placental PRL-family hormone production and fetal growth retardation in mice. / Lee, Chae Kwan; Kang, Sung Goo; Lee, Jong-Tae; Lee, Soo Woong; Kim, Jeong Ho; Kim, Dae Hwan; Son, Byung Chul; Kim, Kun Hyung; Suh, Chun Hui; Kim, Se Yeong; Park, Yeong Beom.

In: Molecular and Cellular Endocrinology, Vol. 401, 05.02.2015, p. 165-172.

Research output: Contribution to journalArticle

Lee, Chae Kwan ; Kang, Sung Goo ; Lee, Jong-Tae ; Lee, Soo Woong ; Kim, Jeong Ho ; Kim, Dae Hwan ; Son, Byung Chul ; Kim, Kun Hyung ; Suh, Chun Hui ; Kim, Se Yeong ; Park, Yeong Beom. / Effects of perfluorooctane sulfuric acid on placental PRL-family hormone production and fetal growth retardation in mice. In: Molecular and Cellular Endocrinology. 2015 ; Vol. 401. pp. 165-172.
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