Effects of psychotropic drugs on seizure threshold during electroconvulsive therapy

Su Hyuk Chi, Hyun Ghang Jeong, Suji Lee, So Young Oh, Seung Hyun Kim

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Objectives To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast). Results Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01). Conclusion Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.

    Original languageEnglish
    Pages (from-to)647-655
    Number of pages9
    JournalPsychiatry Investigation
    Volume14
    Issue number5
    DOIs
    Publication statusPublished - 2017 Sep

    Keywords

    • Antidepressants
    • Antipsychotics
    • Electroconvulsive therapy
    • Seizure threshold

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry

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