Effects of psychotropic drugs on seizure threshold during electroconvulsive therapy

Su Hyuk Chi, Hyun-Ghang Jeong, Suji Lee, So Young Oh, Seung Hyun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast). Results Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01). Conclusion Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.

Original languageEnglish
Pages (from-to)647-655
Number of pages9
JournalPsychiatry Investigation
Volume14
Issue number5
DOIs
Publication statusPublished - 2017 Sep 1

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Electroconvulsive Therapy
Psychotropic Drugs
Seizures
Antidepressive Agents
Antipsychotic Agents
Multivariate Analysis
Fluoxetine
Chlorpromazine
Regression Analysis

Keywords

  • Antidepressants
  • Antipsychotics
  • Electroconvulsive therapy
  • Seizure threshold

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Effects of psychotropic drugs on seizure threshold during electroconvulsive therapy. / Chi, Su Hyuk; Jeong, Hyun-Ghang; Lee, Suji; Oh, So Young; Kim, Seung Hyun.

In: Psychiatry Investigation, Vol. 14, No. 5, 01.09.2017, p. 647-655.

Research output: Contribution to journalArticle

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N2 - Objectives To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast). Results Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01). Conclusion Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.

AB - Objectives To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast). Results Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01). Conclusion Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.

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