Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus: a structural equation modeling approach

Jeong Won Lee, Ji Hyoun Kang, Kyung Eun Lee, Dong Jin Park, Seong Wook Kang, Seung Ki Kwok, Seong Kyu Kim, Jung Yoon Choe, Hyoun Ah Kim, Yoon Kyoung Sung, Kichul Shin, Sang Il Lee, Chang Hoon Lee, Sungjae Choi, Shin Seok Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: This study assessed the relationships among the risk factors for and components of metabolic syndrome (MetS) and health-related quality of life (HRQOL) in a hypothesized causal model using structural equation modeling (SEM) in patients with systemic lupus erythematosus (SLE). Methods: Of the 505 SLE patients enrolled in the Korean Lupus Network (KORNET registry), 244 had sufficient data to assess the components of MetS at enrollment. Education level, monthly income, corticosteroid dose, Systemic Lupus Erythematosus Disease Activity Index, Physicians’ Global Assessment, Beck Depression Inventory, MetS components, and the Short Form-36 at the time of cohort entry were determined. SEM was used to test the causal relationship based on the Analysis of Moment Structure. Results: The average age of the 244 patients was 40.7 ± 11.8 years. The SEM results supported the good fit of the model (χ2 = 71.629, p = 0.078, RMSEA 0.034, CFI 0.972). The final model showed a direct negative effect of higher socioeconomic status and a positive indirect effect of higher disease activity on MetS, the latter through corticosteroid dose. MetS did not directly impact HRQOL but had an indirect negative impact on it, through depression. Conclusions: In our causal model, MetS risk factors were related to MetS components. The latter had a negative indirect impact on HRQOL, through depression. Clinicians should consider socioeconomic status and medication and seek to modify disease activity, MetS, and depression to improve the HRQOL of SLE patients.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalQuality of Life Research
Volume27
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Systemic Lupus Erythematosus
Quality of Life
Social Class
Adrenal Cortex Hormones
Structural Models
Metabolic Diseases
Registries
Physicians
Education
Equipment and Supplies

Keywords

  • Depression
  • Metabolic syndrome
  • Quality of life
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus : a structural equation modeling approach. / Lee, Jeong Won; Kang, Ji Hyoun; Lee, Kyung Eun; Park, Dong Jin; Kang, Seong Wook; Kwok, Seung Ki; Kim, Seong Kyu; Choe, Jung Yoon; Kim, Hyoun Ah; Sung, Yoon Kyoung; Shin, Kichul; Lee, Sang Il; Lee, Chang Hoon; Choi, Sungjae; Lee, Shin Seok.

In: Quality of Life Research, Vol. 27, No. 1, 01.01.2018, p. 105-113.

Research output: Contribution to journalArticle

Lee, JW, Kang, JH, Lee, KE, Park, DJ, Kang, SW, Kwok, SK, Kim, SK, Choe, JY, Kim, HA, Sung, YK, Shin, K, Lee, SI, Lee, CH, Choi, S & Lee, SS 2018, 'Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus: a structural equation modeling approach', Quality of Life Research, vol. 27, no. 1, pp. 105-113. https://doi.org/10.1007/s11136-017-1689-z
Lee, Jeong Won ; Kang, Ji Hyoun ; Lee, Kyung Eun ; Park, Dong Jin ; Kang, Seong Wook ; Kwok, Seung Ki ; Kim, Seong Kyu ; Choe, Jung Yoon ; Kim, Hyoun Ah ; Sung, Yoon Kyoung ; Shin, Kichul ; Lee, Sang Il ; Lee, Chang Hoon ; Choi, Sungjae ; Lee, Shin Seok. / Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus : a structural equation modeling approach. In: Quality of Life Research. 2018 ; Vol. 27, No. 1. pp. 105-113.
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abstract = "Purpose: This study assessed the relationships among the risk factors for and components of metabolic syndrome (MetS) and health-related quality of life (HRQOL) in a hypothesized causal model using structural equation modeling (SEM) in patients with systemic lupus erythematosus (SLE). Methods: Of the 505 SLE patients enrolled in the Korean Lupus Network (KORNET registry), 244 had sufficient data to assess the components of MetS at enrollment. Education level, monthly income, corticosteroid dose, Systemic Lupus Erythematosus Disease Activity Index, Physicians’ Global Assessment, Beck Depression Inventory, MetS components, and the Short Form-36 at the time of cohort entry were determined. SEM was used to test the causal relationship based on the Analysis of Moment Structure. Results: The average age of the 244 patients was 40.7 ± 11.8 years. The SEM results supported the good fit of the model (χ2 = 71.629, p = 0.078, RMSEA 0.034, CFI 0.972). The final model showed a direct negative effect of higher socioeconomic status and a positive indirect effect of higher disease activity on MetS, the latter through corticosteroid dose. MetS did not directly impact HRQOL but had an indirect negative impact on it, through depression. Conclusions: In our causal model, MetS risk factors were related to MetS components. The latter had a negative indirect impact on HRQOL, through depression. Clinicians should consider socioeconomic status and medication and seek to modify disease activity, MetS, and depression to improve the HRQOL of SLE patients.",
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T1 - Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus

T2 - a structural equation modeling approach

AU - Lee, Jeong Won

AU - Kang, Ji Hyoun

AU - Lee, Kyung Eun

AU - Park, Dong Jin

AU - Kang, Seong Wook

AU - Kwok, Seung Ki

AU - Kim, Seong Kyu

AU - Choe, Jung Yoon

AU - Kim, Hyoun Ah

AU - Sung, Yoon Kyoung

AU - Shin, Kichul

AU - Lee, Sang Il

AU - Lee, Chang Hoon

AU - Choi, Sungjae

AU - Lee, Shin Seok

PY - 2018/1/1

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N2 - Purpose: This study assessed the relationships among the risk factors for and components of metabolic syndrome (MetS) and health-related quality of life (HRQOL) in a hypothesized causal model using structural equation modeling (SEM) in patients with systemic lupus erythematosus (SLE). Methods: Of the 505 SLE patients enrolled in the Korean Lupus Network (KORNET registry), 244 had sufficient data to assess the components of MetS at enrollment. Education level, monthly income, corticosteroid dose, Systemic Lupus Erythematosus Disease Activity Index, Physicians’ Global Assessment, Beck Depression Inventory, MetS components, and the Short Form-36 at the time of cohort entry were determined. SEM was used to test the causal relationship based on the Analysis of Moment Structure. Results: The average age of the 244 patients was 40.7 ± 11.8 years. The SEM results supported the good fit of the model (χ2 = 71.629, p = 0.078, RMSEA 0.034, CFI 0.972). The final model showed a direct negative effect of higher socioeconomic status and a positive indirect effect of higher disease activity on MetS, the latter through corticosteroid dose. MetS did not directly impact HRQOL but had an indirect negative impact on it, through depression. Conclusions: In our causal model, MetS risk factors were related to MetS components. The latter had a negative indirect impact on HRQOL, through depression. Clinicians should consider socioeconomic status and medication and seek to modify disease activity, MetS, and depression to improve the HRQOL of SLE patients.

AB - Purpose: This study assessed the relationships among the risk factors for and components of metabolic syndrome (MetS) and health-related quality of life (HRQOL) in a hypothesized causal model using structural equation modeling (SEM) in patients with systemic lupus erythematosus (SLE). Methods: Of the 505 SLE patients enrolled in the Korean Lupus Network (KORNET registry), 244 had sufficient data to assess the components of MetS at enrollment. Education level, monthly income, corticosteroid dose, Systemic Lupus Erythematosus Disease Activity Index, Physicians’ Global Assessment, Beck Depression Inventory, MetS components, and the Short Form-36 at the time of cohort entry were determined. SEM was used to test the causal relationship based on the Analysis of Moment Structure. Results: The average age of the 244 patients was 40.7 ± 11.8 years. The SEM results supported the good fit of the model (χ2 = 71.629, p = 0.078, RMSEA 0.034, CFI 0.972). The final model showed a direct negative effect of higher socioeconomic status and a positive indirect effect of higher disease activity on MetS, the latter through corticosteroid dose. MetS did not directly impact HRQOL but had an indirect negative impact on it, through depression. Conclusions: In our causal model, MetS risk factors were related to MetS components. The latter had a negative indirect impact on HRQOL, through depression. Clinicians should consider socioeconomic status and medication and seek to modify disease activity, MetS, and depression to improve the HRQOL of SLE patients.

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KW - Metabolic syndrome

KW - Quality of life

KW - Systemic lupus erythematosus

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