Effects of silver nanoparticles on the fluidity of bilayer in phospholipid liposome

Sung Hee Park, Seong Geun Oh, Ji Young Mun, Sung Sik Han

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

This paper describes the formation and characterization of liposome entrapping the silver nanoparticles in bilayer. Silver nanoparticles were entrapped in the bilayer of dipalmitoylphosphatidylcholine (DPPC) liposome, named as silver-loaded liposome. Specifically, above the gel to liquid-crystalline phase transition temperature of this lipid (i.e., 41°C), it was observed that membrane fluidities of silver-loaded liposomes were increased, and fluorescence anisotropy values were reduced from 0.114 to 0.097. This might be due to the structural modifications and interactions between DPPC molecules and silver nanoparticles within the bilayer. It was also confirmed that silver nanoparticles were entrapped in hydrophobic region of lipid bilayer with transmission electron microscopy (TEM) and electron energy loss spectroscopy (EELS) measurements.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Volume44
Issue number2-3
DOIs
Publication statusPublished - 2005 Aug 1

Fingerprint

Membrane Fluidity
Fluidity
Liposomes
Phospholipids
Silver
Nanoparticles
silver
nanoparticles
1,2-Dipalmitoylphosphatidylcholine
lipids
Electron Energy-Loss Spectroscopy
Lipid bilayers
Fluorescence Polarization
Transition Temperature
Electron energy loss spectroscopy
Phase Transition
Lipid Bilayers
Transmission Electron Microscopy
Lipids
Superconducting transition temperature

Keywords

  • Bilayer
  • Liposomes
  • Membrane fluidity
  • Silver nanoparticle

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Effects of silver nanoparticles on the fluidity of bilayer in phospholipid liposome. / Park, Sung Hee; Oh, Seong Geun; Mun, Ji Young; Han, Sung Sik.

In: Colloids and Surfaces B: Biointerfaces, Vol. 44, No. 2-3, 01.08.2005, p. 117-122.

Research output: Contribution to journalArticle

Park, Sung Hee ; Oh, Seong Geun ; Mun, Ji Young ; Han, Sung Sik. / Effects of silver nanoparticles on the fluidity of bilayer in phospholipid liposome. In: Colloids and Surfaces B: Biointerfaces. 2005 ; Vol. 44, No. 2-3. pp. 117-122.
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