Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients

Min-Jeong Shin, Namsik Chung, Jong H. Lee, Yangsoo Jang, Eunju Park, Kyung I. Jeon, Ji Hyung Chung, Bo Young Seo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Statins are known to possess antioxidant properties in addition to their cholesterol-lowering effects. However, recent studies have suggested that statins reduce the levels of antioxidant vitamins such as vitamin E and coenzyme Q10, possibly resulting in impaired left ventricular function. We investigated the effects of simvastatin on the blood lipids, LDL oxidation and plasma antioxidant status, and whether these effects were associated with changes in plasma antioxidant vitamin levels. Methods: Simvastatin (20-40 mg/day) was administered for 8 weeks in seventy-six hypercholesterolemic patients. We measured plasma lipids, oxidized LDL, total radical trapping antioxidant potential (TRAP) and plasma antioxidant vitamin levels at baseline and after 8 weeks of simvastatin administration. Results: Simvastatin significantly lowered serum levels of total cholesterol and LDL-cholesterol by 30.1% and 41.9%, respectively. A significant reduction in oxidized LDL levels (p < 0.0001) and improvement in plasma antioxidant status as measured by TRAP (p < 0.05) after the 8-week simvastatin treatment were observed. Regarding the effects of simvastatin on plasma antioxidant vitamin levels, there were significant increases in the levels of lipid-corrected retinol (p < 0.001), α-tocopherol (p < 0.001) and γ-tocopherol (p < 0.005) after the 8-week simvastatin treatment. Lipid-corrected levels of coenzyme Q10 and carotenoids remained unchanged after simvastatin treatment. Conclusions: Our results show that simvastatin reduced blood lipids and circulating oxidized LDL, and improved plasma antioxidant status without altering the antioxidant vitamin system. These data indicate that simvastatin not only decreases blood lipids and circulating oxidized LDL but also increases lipid corrected levels of antioxidant vitamins and may improve plasma antioxidant status synergizing with the biological effects of antioxidants.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalInternational Journal of Cardiology
Volume118
Issue number2
DOIs
Publication statusPublished - 2007 May 31
Externally publishedYes

Fingerprint

Simvastatin
Vitamins
Antioxidants
coenzyme Q10
Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Tocopherols
Cholesterol
Carotenoids
Vitamin A
Vitamin E
Left Ventricular Function
LDL Cholesterol

Keywords

  • Antioxidant vitamins
  • ox-LDL
  • Simvastatin
  • TRAP

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients. / Shin, Min-Jeong; Chung, Namsik; Lee, Jong H.; Jang, Yangsoo; Park, Eunju; Jeon, Kyung I.; Chung, Ji Hyung; Seo, Bo Young.

In: International Journal of Cardiology, Vol. 118, No. 2, 31.05.2007, p. 173-177.

Research output: Contribution to journalArticle

Shin, Min-Jeong ; Chung, Namsik ; Lee, Jong H. ; Jang, Yangsoo ; Park, Eunju ; Jeon, Kyung I. ; Chung, Ji Hyung ; Seo, Bo Young. / Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients. In: International Journal of Cardiology. 2007 ; Vol. 118, No. 2. pp. 173-177.
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abstract = "Background: Statins are known to possess antioxidant properties in addition to their cholesterol-lowering effects. However, recent studies have suggested that statins reduce the levels of antioxidant vitamins such as vitamin E and coenzyme Q10, possibly resulting in impaired left ventricular function. We investigated the effects of simvastatin on the blood lipids, LDL oxidation and plasma antioxidant status, and whether these effects were associated with changes in plasma antioxidant vitamin levels. Methods: Simvastatin (20-40 mg/day) was administered for 8 weeks in seventy-six hypercholesterolemic patients. We measured plasma lipids, oxidized LDL, total radical trapping antioxidant potential (TRAP) and plasma antioxidant vitamin levels at baseline and after 8 weeks of simvastatin administration. Results: Simvastatin significantly lowered serum levels of total cholesterol and LDL-cholesterol by 30.1{\%} and 41.9{\%}, respectively. A significant reduction in oxidized LDL levels (p < 0.0001) and improvement in plasma antioxidant status as measured by TRAP (p < 0.05) after the 8-week simvastatin treatment were observed. Regarding the effects of simvastatin on plasma antioxidant vitamin levels, there were significant increases in the levels of lipid-corrected retinol (p < 0.001), α-tocopherol (p < 0.001) and γ-tocopherol (p < 0.005) after the 8-week simvastatin treatment. Lipid-corrected levels of coenzyme Q10 and carotenoids remained unchanged after simvastatin treatment. Conclusions: Our results show that simvastatin reduced blood lipids and circulating oxidized LDL, and improved plasma antioxidant status without altering the antioxidant vitamin system. These data indicate that simvastatin not only decreases blood lipids and circulating oxidized LDL but also increases lipid corrected levels of antioxidant vitamins and may improve plasma antioxidant status synergizing with the biological effects of antioxidants.",
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AU - Lee, Jong H.

AU - Jang, Yangsoo

AU - Park, Eunju

AU - Jeon, Kyung I.

AU - Chung, Ji Hyung

AU - Seo, Bo Young

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AB - Background: Statins are known to possess antioxidant properties in addition to their cholesterol-lowering effects. However, recent studies have suggested that statins reduce the levels of antioxidant vitamins such as vitamin E and coenzyme Q10, possibly resulting in impaired left ventricular function. We investigated the effects of simvastatin on the blood lipids, LDL oxidation and plasma antioxidant status, and whether these effects were associated with changes in plasma antioxidant vitamin levels. Methods: Simvastatin (20-40 mg/day) was administered for 8 weeks in seventy-six hypercholesterolemic patients. We measured plasma lipids, oxidized LDL, total radical trapping antioxidant potential (TRAP) and plasma antioxidant vitamin levels at baseline and after 8 weeks of simvastatin administration. Results: Simvastatin significantly lowered serum levels of total cholesterol and LDL-cholesterol by 30.1% and 41.9%, respectively. A significant reduction in oxidized LDL levels (p < 0.0001) and improvement in plasma antioxidant status as measured by TRAP (p < 0.05) after the 8-week simvastatin treatment were observed. Regarding the effects of simvastatin on plasma antioxidant vitamin levels, there were significant increases in the levels of lipid-corrected retinol (p < 0.001), α-tocopherol (p < 0.001) and γ-tocopherol (p < 0.005) after the 8-week simvastatin treatment. Lipid-corrected levels of coenzyme Q10 and carotenoids remained unchanged after simvastatin treatment. Conclusions: Our results show that simvastatin reduced blood lipids and circulating oxidized LDL, and improved plasma antioxidant status without altering the antioxidant vitamin system. These data indicate that simvastatin not only decreases blood lipids and circulating oxidized LDL but also increases lipid corrected levels of antioxidant vitamins and may improve plasma antioxidant status synergizing with the biological effects of antioxidants.

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