Effects of smoking on coronary blood flow velocity and coronary flow reserve assessed by transthoracic Doppler echocardiography

Seong-Mi Park, Wan Joo Shim, Woohyuk Song, Do-Sun Lim, Young Hoon Kim, Young Moo Ro

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Smoking is a well-known risk factor for cardiovascular disease. Coronary blood flow velocity (CFV) can be measured directly with transthoracic Doppler echocardiography (TTDE) which is conducted immediately after smoking. Purpose: The purpose of this study was to evaluate the chronic and acute effects of smoking on coronary blood flow and coronary flow reserve (CFR) by the use of TTDE. Methods: Healthy volunteers (11 smokers and 9 nonsmokers) with a mean age of 27 ± 3 years were included. Smoking was abstained for at least 4 hours before the study. CFV was measured at the distal left anterior descending coronary artery by TTDE at baseline and during intravenous adenosine infusion (140 μg/kg per minute) in all participants. For smokers, CFV was measured immediately after consecutively smoking two cigarettes and during adenosine infusion. Results: CFR and coronary vascular resistance index (CVRI) showed no significant difference between nonsmokers and smokers (CFR: 3.5 ± 0.8 vs 3.6 ± 0.6, P = ns, CVRI: 0.28 vs 0.28, P = ns) at baseline. CFR significantly decreased (3.6 ± 0.6 to 2.8 ± 0.7, P = 0.008) and CVRI markedly increased (0.28 to 0.35, P = 0.012) after smoking. Conclusion: After 4 hours of abstinence from smoking, CFR and CVRI in smokers were similar to those of nonsmokers. However, consecutively smoking two cigarettes acutely reduced CFR and increased CVRI. These findings suggested that smoking could reduce coronary blood flow immediately, even in healthy people.

Original languageEnglish
Pages (from-to)465-470
Number of pages6
JournalEchocardiography
Volume23
Issue number6
DOIs
Publication statusPublished - 2006 Jul 1

Fingerprint

Blood Flow Velocity
Doppler Echocardiography
Echocardiography
Smoking
Vascular Resistance
Adenosine
Intravenous Infusions
Coronary Vessels
Healthy Volunteers
Cardiovascular Diseases

Keywords

  • Coronary blood flow velocity
  • Coronary flow reserve
  • Smoking
  • Transthoracic Doppler echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

@article{f1df32c4721743c8b5abe14307f68fb9,
title = "Effects of smoking on coronary blood flow velocity and coronary flow reserve assessed by transthoracic Doppler echocardiography",
abstract = "Background: Smoking is a well-known risk factor for cardiovascular disease. Coronary blood flow velocity (CFV) can be measured directly with transthoracic Doppler echocardiography (TTDE) which is conducted immediately after smoking. Purpose: The purpose of this study was to evaluate the chronic and acute effects of smoking on coronary blood flow and coronary flow reserve (CFR) by the use of TTDE. Methods: Healthy volunteers (11 smokers and 9 nonsmokers) with a mean age of 27 ± 3 years were included. Smoking was abstained for at least 4 hours before the study. CFV was measured at the distal left anterior descending coronary artery by TTDE at baseline and during intravenous adenosine infusion (140 μg/kg per minute) in all participants. For smokers, CFV was measured immediately after consecutively smoking two cigarettes and during adenosine infusion. Results: CFR and coronary vascular resistance index (CVRI) showed no significant difference between nonsmokers and smokers (CFR: 3.5 ± 0.8 vs 3.6 ± 0.6, P = ns, CVRI: 0.28 vs 0.28, P = ns) at baseline. CFR significantly decreased (3.6 ± 0.6 to 2.8 ± 0.7, P = 0.008) and CVRI markedly increased (0.28 to 0.35, P = 0.012) after smoking. Conclusion: After 4 hours of abstinence from smoking, CFR and CVRI in smokers were similar to those of nonsmokers. However, consecutively smoking two cigarettes acutely reduced CFR and increased CVRI. These findings suggested that smoking could reduce coronary blood flow immediately, even in healthy people.",
keywords = "Coronary blood flow velocity, Coronary flow reserve, Smoking, Transthoracic Doppler echocardiography",
author = "Seong-Mi Park and Shim, {Wan Joo} and Woohyuk Song and Do-Sun Lim and Kim, {Young Hoon} and Ro, {Young Moo}",
year = "2006",
month = "7",
day = "1",
doi = "10.1111/j.1540-8175.2006.00242.x",
language = "English",
volume = "23",
pages = "465--470",
journal = "Echocardiography",
issn = "0742-2822",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Effects of smoking on coronary blood flow velocity and coronary flow reserve assessed by transthoracic Doppler echocardiography

AU - Park, Seong-Mi

AU - Shim, Wan Joo

AU - Song, Woohyuk

AU - Lim, Do-Sun

AU - Kim, Young Hoon

AU - Ro, Young Moo

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Background: Smoking is a well-known risk factor for cardiovascular disease. Coronary blood flow velocity (CFV) can be measured directly with transthoracic Doppler echocardiography (TTDE) which is conducted immediately after smoking. Purpose: The purpose of this study was to evaluate the chronic and acute effects of smoking on coronary blood flow and coronary flow reserve (CFR) by the use of TTDE. Methods: Healthy volunteers (11 smokers and 9 nonsmokers) with a mean age of 27 ± 3 years were included. Smoking was abstained for at least 4 hours before the study. CFV was measured at the distal left anterior descending coronary artery by TTDE at baseline and during intravenous adenosine infusion (140 μg/kg per minute) in all participants. For smokers, CFV was measured immediately after consecutively smoking two cigarettes and during adenosine infusion. Results: CFR and coronary vascular resistance index (CVRI) showed no significant difference between nonsmokers and smokers (CFR: 3.5 ± 0.8 vs 3.6 ± 0.6, P = ns, CVRI: 0.28 vs 0.28, P = ns) at baseline. CFR significantly decreased (3.6 ± 0.6 to 2.8 ± 0.7, P = 0.008) and CVRI markedly increased (0.28 to 0.35, P = 0.012) after smoking. Conclusion: After 4 hours of abstinence from smoking, CFR and CVRI in smokers were similar to those of nonsmokers. However, consecutively smoking two cigarettes acutely reduced CFR and increased CVRI. These findings suggested that smoking could reduce coronary blood flow immediately, even in healthy people.

AB - Background: Smoking is a well-known risk factor for cardiovascular disease. Coronary blood flow velocity (CFV) can be measured directly with transthoracic Doppler echocardiography (TTDE) which is conducted immediately after smoking. Purpose: The purpose of this study was to evaluate the chronic and acute effects of smoking on coronary blood flow and coronary flow reserve (CFR) by the use of TTDE. Methods: Healthy volunteers (11 smokers and 9 nonsmokers) with a mean age of 27 ± 3 years were included. Smoking was abstained for at least 4 hours before the study. CFV was measured at the distal left anterior descending coronary artery by TTDE at baseline and during intravenous adenosine infusion (140 μg/kg per minute) in all participants. For smokers, CFV was measured immediately after consecutively smoking two cigarettes and during adenosine infusion. Results: CFR and coronary vascular resistance index (CVRI) showed no significant difference between nonsmokers and smokers (CFR: 3.5 ± 0.8 vs 3.6 ± 0.6, P = ns, CVRI: 0.28 vs 0.28, P = ns) at baseline. CFR significantly decreased (3.6 ± 0.6 to 2.8 ± 0.7, P = 0.008) and CVRI markedly increased (0.28 to 0.35, P = 0.012) after smoking. Conclusion: After 4 hours of abstinence from smoking, CFR and CVRI in smokers were similar to those of nonsmokers. However, consecutively smoking two cigarettes acutely reduced CFR and increased CVRI. These findings suggested that smoking could reduce coronary blood flow immediately, even in healthy people.

KW - Coronary blood flow velocity

KW - Coronary flow reserve

KW - Smoking

KW - Transthoracic Doppler echocardiography

UR - http://www.scopus.com/inward/record.url?scp=33748561482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748561482&partnerID=8YFLogxK

U2 - 10.1111/j.1540-8175.2006.00242.x

DO - 10.1111/j.1540-8175.2006.00242.x

M3 - Article

C2 - 16839383

AN - SCOPUS:33748561482

VL - 23

SP - 465

EP - 470

JO - Echocardiography

JF - Echocardiography

SN - 0742-2822

IS - 6

ER -