Effects of soy phytoestrogens on reference memory and neuronal cholinergic enzymes in ovariectomized rats

Yoon Bok Lee, Keun Ha Lee, Heon Soo Sohn, Sung-Joon Lee, Kyung-Hwan Cho, Il Jun Kang, Dong Woo Kim, Yong Kook Shin, Tongkun Pai, In Koo Hwang, Moo Ho Won

Research output: Contribution to journalArticle

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Abstract

The effects of soy phytoestrogens on Morris water maze (MWM) performance and neuronal cholinergic enzyme activities and immunoreactivity were studied in ovariectomized (OVX) rats. The rats were assigned to four groups fed control diet (CD), 3.9 mg/kg 17β-estradiol diet (E2), 263.4 mg/kg soy phytoestrogens diet (SP1), and 526.9 mg/kg soy phytoestrogens diet (SP2). In the MWM task, escape latency and path length were significantly less in the E2 and SP2 groups than in the CD group on the second day. Choline acetyltransferase (ChAT) activity in the cerebral cortex and ChAT immunoreactivity in the diagonal band of Broca were significantly greater in the E2, SP1, and SP2 groups than in the CD group. Acetylcholinesterase activity in the hippocampus in the E2, SP1, and SP2 groups was significantly lower than in the CD group. This study suggests that soy phytoestrogens affect the reference memory and neuronal cholinergic system in OVX rats.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalJournal of Medicinal Food
Volume12
Issue number1
DOIs
Publication statusPublished - 2009 Feb 1

Fingerprint

Phytoestrogens
Cholinergic Agents
Diet
Enzymes
Control Groups
Choline O-Acetyltransferase
Diagonal Band of Broca
Water
Acetylcholinesterase
Cerebral Cortex
Estradiol
Hippocampus

Keywords

  • Acetylcholine esterase
  • Choline acetyltransferase
  • Morris water maze
  • Ovariectomy
  • Soy phytoestrogens

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of soy phytoestrogens on reference memory and neuronal cholinergic enzymes in ovariectomized rats. / Lee, Yoon Bok; Lee, Keun Ha; Sohn, Heon Soo; Lee, Sung-Joon; Cho, Kyung-Hwan; Kang, Il Jun; Kim, Dong Woo; Shin, Yong Kook; Pai, Tongkun; Hwang, In Koo; Won, Moo Ho.

In: Journal of Medicinal Food, Vol. 12, No. 1, 01.02.2009, p. 64-70.

Research output: Contribution to journalArticle

Lee, Yoon Bok ; Lee, Keun Ha ; Sohn, Heon Soo ; Lee, Sung-Joon ; Cho, Kyung-Hwan ; Kang, Il Jun ; Kim, Dong Woo ; Shin, Yong Kook ; Pai, Tongkun ; Hwang, In Koo ; Won, Moo Ho. / Effects of soy phytoestrogens on reference memory and neuronal cholinergic enzymes in ovariectomized rats. In: Journal of Medicinal Food. 2009 ; Vol. 12, No. 1. pp. 64-70.
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