Effects of teriparatide on fusion rates in patients undergoing complex foot and ankle arthrodesis

Hee Seop Lee, Jung Ho Park, Dong Hun Suh, Hak Jun Kim, Bong Mo Koo, Hak Kyu Kim, Se Hyun Yang, Gi Won Choi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Here, we determined whether teriparatide treatment would increase fusion rates after foot and ankle arthrodesis by comparing treatment results between patients with high-risk factors for nonunion who received teriparatide against those who did not. Methods: We retrospectively reviewed 66 consecutive patients who underwent foot and ankle arthrodesis. The inclusion criterion was the presence of at least one of the following risk factors for nonunion after previous foot and ankle arthrodesis: deformity, bone defects, avascular necrosis, and nonunion. Sixteen patients were finally enrolled and divided into 2 groups: 8 patients received teriparatide treatment after fusion surgery (PTH group), and 8 patients did not (control group). Results: The fusion rate was significantly greater in the PTH group than in the control group (100% vs 50%). Four patients in the control group developed nonunion, 3 of whom underwent revision fusion; however, all patients received the teriparatide treatment after revision surgery and subsequently achieved union. No significant differences in demographics, fusion sites, and complication rates were found. Conclusion: Though the sample size was small, the current study suggests that teriparatide administration may improve fusion rates in patients with high-risk factors for nonunion after foot and ankle arthrodesis.

    Original languageEnglish
    Pages (from-to)766-770
    Number of pages5
    JournalFoot and Ankle Surgery
    Volume26
    Issue number7
    DOIs
    Publication statusPublished - 2020 Oct

    Keywords

    • Ankle
    • Arthrodesis
    • Foot
    • Fusion
    • Nonunion
    • Teriparatide

    ASJC Scopus subject areas

    • Orthopedics and Sports Medicine

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