Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

Yong Seok Jee, Il Gyu Ko, Yun Hee Sung, Jin Woo Lee, Young Sick Kim, Sung Eun Kim, Bo Kyun Kim, Jin Hee Seo, Mal Soon Shin, Hee Hyuk Lee, Han Jin Cho, Chang Ju Kim

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalNeuroscience Letters
Volume443
Issue number3
DOIs
Publication statusPublished - 2008 Oct 10
Externally publishedYes

Fingerprint

Streptozocin
Hippocampus
Long-Term Memory
Alzheimer Disease
Injections
Neurodegenerative Diseases
Immediate-Early Genes
Memory Disorders
Dementia
Neurons
Wounds and Injuries

Keywords

  • Alzheimer' disease
  • c-Fos
  • Hippocampus
  • Long-term memory
  • Streptozotocin
  • Treadmill exercise

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin. / Jee, Yong Seok; Ko, Il Gyu; Sung, Yun Hee; Lee, Jin Woo; Kim, Young Sick; Kim, Sung Eun; Kim, Bo Kyun; Seo, Jin Hee; Shin, Mal Soon; Lee, Hee Hyuk; Cho, Han Jin; Kim, Chang Ju.

In: Neuroscience Letters, Vol. 443, No. 3, 10.10.2008, p. 188-192.

Research output: Contribution to journalArticle

Jee, Yong Seok ; Ko, Il Gyu ; Sung, Yun Hee ; Lee, Jin Woo ; Kim, Young Sick ; Kim, Sung Eun ; Kim, Bo Kyun ; Seo, Jin Hee ; Shin, Mal Soon ; Lee, Hee Hyuk ; Cho, Han Jin ; Kim, Chang Ju. / Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin. In: Neuroscience Letters. 2008 ; Vol. 443, No. 3. pp. 188-192.
@article{4e2b790c48a54f1e8e1aa7714058031e,
title = "Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin",
abstract = "Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases.",
keywords = "Alzheimer' disease, c-Fos, Hippocampus, Long-term memory, Streptozotocin, Treadmill exercise",
author = "Jee, {Yong Seok} and Ko, {Il Gyu} and Sung, {Yun Hee} and Lee, {Jin Woo} and Kim, {Young Sick} and Kim, {Sung Eun} and Kim, {Bo Kyun} and Seo, {Jin Hee} and Shin, {Mal Soon} and Lee, {Hee Hyuk} and Cho, {Han Jin} and Kim, {Chang Ju}",
year = "2008",
month = "10",
day = "10",
doi = "10.1016/j.neulet.2008.07.078",
language = "English",
volume = "443",
pages = "188--192",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

AU - Jee, Yong Seok

AU - Ko, Il Gyu

AU - Sung, Yun Hee

AU - Lee, Jin Woo

AU - Kim, Young Sick

AU - Kim, Sung Eun

AU - Kim, Bo Kyun

AU - Seo, Jin Hee

AU - Shin, Mal Soon

AU - Lee, Hee Hyuk

AU - Cho, Han Jin

AU - Kim, Chang Ju

PY - 2008/10/10

Y1 - 2008/10/10

N2 - Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases.

AB - Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. The immediate early gene c-Fos has been used as a marker of neuronal activity. In the present study, we investigated the effects of treadmill exercise on long-term memory capacity and c-Fos expression in the hippocampus of rats with Alzheimer's disease. The rat model of Alzheimer's disease used in the present study was induced by the intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 14 consecutive days starting at 3 days after the ICV injection of STZ. The results of the present study showed that ICV injection of STZ impaired long-term memory capacity and decreased the number of c-Fos-positive cells in several regions of the rat hippocampus. However, treadmill exercise alleviated long-term memory deficits and enhanced c-Fos expression in the rats with ICV injection of STZ. The results of the present study showed that treadmill exercise could be a useful strategy for treating several neurodegenerative diseases.

KW - Alzheimer' disease

KW - c-Fos

KW - Hippocampus

KW - Long-term memory

KW - Streptozotocin

KW - Treadmill exercise

UR - http://www.scopus.com/inward/record.url?scp=50249106878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50249106878&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2008.07.078

DO - 10.1016/j.neulet.2008.07.078

M3 - Article

C2 - 18687381

AN - SCOPUS:50249106878

VL - 443

SP - 188

EP - 192

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -