Effects of Variant Histology on the Oncologic Outcomes of Patients With Upper Urinary Tract Carcinoma After Radical Nephroureterectomy

A Propensity Score–Matched Analysis

Ho Seok Chung, Eu Chang Hwang, Myung Soo Kim, Seong Hyeon Yu, Seung Il Jung, Taek Won Kang, Chan Choi, Seock Hwan Choi, Tae Gyun Kwon, Joon Hwa Noh, Myung Ki Kim, Won Jin Cho, Sung-Gu Kang, Seok Ho Kang, Jun Cheon, Ill Young Seo, Hong Chung, Hong Sup Kim, Chan Ho Lee, Ja Yoon Ku & 6 others Hong Koo Ha, Byung Hoon Kim, Chang Wook Jeong, Ja Hyeon Ku, Cheol Kwak, Dongdeuk Kwon

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the prognostic effect of upper tract urothelial carcinoma (UTUC) with variant histology (VH) after radical nephroureterectomy (RNU). Patients and Methods: The data of 1173 patients who received RNU for UTUC without neoadjuvant chemotherapy in 11 institutions between 2002 and 2016 were retrospectively reviewed. A matched propensity score analysis was performed. Clinicopathologic variables, recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were compared between patients with pure UTUC and patients with UTUC and VH. Univariate and multivariate Cox proportional regression models were used to determine the independent variables associated with oncologic outcomes. Results: UTUC with VH was observed in 93 patients (7.9%). After propensity score matching, UTUC with VH showed no difference in clinicopathologic features compared to pure UTUC; however, it was associated with shorter RFS, CSS, and OS (log rank, P =.011, P =.002, P =.006, respectively). Additionally, the multivariate analysis revealed that VH was independently associated with a poor RFS [hazard ratio (HR) = 1.92; 95% confidence interval (CI), 1.27-2.89; P =.002], CSS (HR = 4.47; 95% CI, 1.99-10.1; P =.001), and OS (HR = 3.00; 95% CI, 1.55-5.78; P =.001). However, the Kaplan-Meier method revealed that differences in RFS, CSS, and OS were not significant in patients who received adjuvant chemotherapy (log rank, P =.562, P =.060, P =.153, respectively). Conclusion: UTUC with VH was independently associated with poor oncologic outcomes in patients with UTUC after RNU. Although patients with UTUC and VH had a poor prognosis compared to patients with pure UTUC, adjuvant chemotherapy would be helpful in improving the survival rates of these patients. Because of its rarity, reports focusing on patients with upper tract urothelial carcinoma (UTUC) and variant histology (VH) are limited. The current study results suggest that VH is an independent prognostic factor associated with recurrence-free survival, cancer-specific survival, and overall survival in patients with UTUC after radical nephroureterectomy. Although patients with UTUC and VH had a poor prognosis compared to those with pure UTUC, the results suggest that adjuvant chemotherapy could improve oncologic outcomes in these patients.

Original languageEnglish
JournalClinical Genitourinary Cancer
DOIs
Publication statusPublished - 2019 Jan 1

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Urinary Tract
Histology
Carcinoma
Survival
Recurrence
Adjuvant Chemotherapy
Propensity Score
Confidence Intervals
Neoplasms
Multivariate Analysis
Survival Rate

Keywords

  • Histology
  • Nephroureterectomy
  • Prognosis
  • Survival
  • Urothelium

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Effects of Variant Histology on the Oncologic Outcomes of Patients With Upper Urinary Tract Carcinoma After Radical Nephroureterectomy : A Propensity Score–Matched Analysis. / Chung, Ho Seok; Hwang, Eu Chang; Kim, Myung Soo; Yu, Seong Hyeon; Jung, Seung Il; Kang, Taek Won; Choi, Chan; Choi, Seock Hwan; Kwon, Tae Gyun; Noh, Joon Hwa; Kim, Myung Ki; Cho, Won Jin; Kang, Sung-Gu; Kang, Seok Ho; Cheon, Jun; Seo, Ill Young; Chung, Hong; Kim, Hong Sup; Lee, Chan Ho; Ku, Ja Yoon; Ha, Hong Koo; Kim, Byung Hoon; Jeong, Chang Wook; Ku, Ja Hyeon; Kwak, Cheol; Kwon, Dongdeuk.

In: Clinical Genitourinary Cancer, 01.01.2019.

Research output: Contribution to journalArticle

Chung, HS, Hwang, EC, Kim, MS, Yu, SH, Jung, SI, Kang, TW, Choi, C, Choi, SH, Kwon, TG, Noh, JH, Kim, MK, Cho, WJ, Kang, S-G, Kang, SH, Cheon, J, Seo, IY, Chung, H, Kim, HS, Lee, CH, Ku, JY, Ha, HK, Kim, BH, Jeong, CW, Ku, JH, Kwak, C & Kwon, D 2019, 'Effects of Variant Histology on the Oncologic Outcomes of Patients With Upper Urinary Tract Carcinoma After Radical Nephroureterectomy: A Propensity Score–Matched Analysis', Clinical Genitourinary Cancer. https://doi.org/10.1016/j.clgc.2018.11.015
Chung, Ho Seok ; Hwang, Eu Chang ; Kim, Myung Soo ; Yu, Seong Hyeon ; Jung, Seung Il ; Kang, Taek Won ; Choi, Chan ; Choi, Seock Hwan ; Kwon, Tae Gyun ; Noh, Joon Hwa ; Kim, Myung Ki ; Cho, Won Jin ; Kang, Sung-Gu ; Kang, Seok Ho ; Cheon, Jun ; Seo, Ill Young ; Chung, Hong ; Kim, Hong Sup ; Lee, Chan Ho ; Ku, Ja Yoon ; Ha, Hong Koo ; Kim, Byung Hoon ; Jeong, Chang Wook ; Ku, Ja Hyeon ; Kwak, Cheol ; Kwon, Dongdeuk. / Effects of Variant Histology on the Oncologic Outcomes of Patients With Upper Urinary Tract Carcinoma After Radical Nephroureterectomy : A Propensity Score–Matched Analysis. In: Clinical Genitourinary Cancer. 2019.
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title = "Effects of Variant Histology on the Oncologic Outcomes of Patients With Upper Urinary Tract Carcinoma After Radical Nephroureterectomy: A Propensity Score–Matched Analysis",
abstract = "Purpose: To determine the prognostic effect of upper tract urothelial carcinoma (UTUC) with variant histology (VH) after radical nephroureterectomy (RNU). Patients and Methods: The data of 1173 patients who received RNU for UTUC without neoadjuvant chemotherapy in 11 institutions between 2002 and 2016 were retrospectively reviewed. A matched propensity score analysis was performed. Clinicopathologic variables, recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were compared between patients with pure UTUC and patients with UTUC and VH. Univariate and multivariate Cox proportional regression models were used to determine the independent variables associated with oncologic outcomes. Results: UTUC with VH was observed in 93 patients (7.9{\%}). After propensity score matching, UTUC with VH showed no difference in clinicopathologic features compared to pure UTUC; however, it was associated with shorter RFS, CSS, and OS (log rank, P =.011, P =.002, P =.006, respectively). Additionally, the multivariate analysis revealed that VH was independently associated with a poor RFS [hazard ratio (HR) = 1.92; 95{\%} confidence interval (CI), 1.27-2.89; P =.002], CSS (HR = 4.47; 95{\%} CI, 1.99-10.1; P =.001), and OS (HR = 3.00; 95{\%} CI, 1.55-5.78; P =.001). However, the Kaplan-Meier method revealed that differences in RFS, CSS, and OS were not significant in patients who received adjuvant chemotherapy (log rank, P =.562, P =.060, P =.153, respectively). Conclusion: UTUC with VH was independently associated with poor oncologic outcomes in patients with UTUC after RNU. Although patients with UTUC and VH had a poor prognosis compared to patients with pure UTUC, adjuvant chemotherapy would be helpful in improving the survival rates of these patients. Because of its rarity, reports focusing on patients with upper tract urothelial carcinoma (UTUC) and variant histology (VH) are limited. The current study results suggest that VH is an independent prognostic factor associated with recurrence-free survival, cancer-specific survival, and overall survival in patients with UTUC after radical nephroureterectomy. Although patients with UTUC and VH had a poor prognosis compared to those with pure UTUC, the results suggest that adjuvant chemotherapy could improve oncologic outcomes in these patients.",
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day = "1",
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TY - JOUR

T1 - Effects of Variant Histology on the Oncologic Outcomes of Patients With Upper Urinary Tract Carcinoma After Radical Nephroureterectomy

T2 - A Propensity Score–Matched Analysis

AU - Chung, Ho Seok

AU - Hwang, Eu Chang

AU - Kim, Myung Soo

AU - Yu, Seong Hyeon

AU - Jung, Seung Il

AU - Kang, Taek Won

AU - Choi, Chan

AU - Choi, Seock Hwan

AU - Kwon, Tae Gyun

AU - Noh, Joon Hwa

AU - Kim, Myung Ki

AU - Cho, Won Jin

AU - Kang, Sung-Gu

AU - Kang, Seok Ho

AU - Cheon, Jun

AU - Seo, Ill Young

AU - Chung, Hong

AU - Kim, Hong Sup

AU - Lee, Chan Ho

AU - Ku, Ja Yoon

AU - Ha, Hong Koo

AU - Kim, Byung Hoon

AU - Jeong, Chang Wook

AU - Ku, Ja Hyeon

AU - Kwak, Cheol

AU - Kwon, Dongdeuk

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To determine the prognostic effect of upper tract urothelial carcinoma (UTUC) with variant histology (VH) after radical nephroureterectomy (RNU). Patients and Methods: The data of 1173 patients who received RNU for UTUC without neoadjuvant chemotherapy in 11 institutions between 2002 and 2016 were retrospectively reviewed. A matched propensity score analysis was performed. Clinicopathologic variables, recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were compared between patients with pure UTUC and patients with UTUC and VH. Univariate and multivariate Cox proportional regression models were used to determine the independent variables associated with oncologic outcomes. Results: UTUC with VH was observed in 93 patients (7.9%). After propensity score matching, UTUC with VH showed no difference in clinicopathologic features compared to pure UTUC; however, it was associated with shorter RFS, CSS, and OS (log rank, P =.011, P =.002, P =.006, respectively). Additionally, the multivariate analysis revealed that VH was independently associated with a poor RFS [hazard ratio (HR) = 1.92; 95% confidence interval (CI), 1.27-2.89; P =.002], CSS (HR = 4.47; 95% CI, 1.99-10.1; P =.001), and OS (HR = 3.00; 95% CI, 1.55-5.78; P =.001). However, the Kaplan-Meier method revealed that differences in RFS, CSS, and OS were not significant in patients who received adjuvant chemotherapy (log rank, P =.562, P =.060, P =.153, respectively). Conclusion: UTUC with VH was independently associated with poor oncologic outcomes in patients with UTUC after RNU. Although patients with UTUC and VH had a poor prognosis compared to patients with pure UTUC, adjuvant chemotherapy would be helpful in improving the survival rates of these patients. Because of its rarity, reports focusing on patients with upper tract urothelial carcinoma (UTUC) and variant histology (VH) are limited. The current study results suggest that VH is an independent prognostic factor associated with recurrence-free survival, cancer-specific survival, and overall survival in patients with UTUC after radical nephroureterectomy. Although patients with UTUC and VH had a poor prognosis compared to those with pure UTUC, the results suggest that adjuvant chemotherapy could improve oncologic outcomes in these patients.

AB - Purpose: To determine the prognostic effect of upper tract urothelial carcinoma (UTUC) with variant histology (VH) after radical nephroureterectomy (RNU). Patients and Methods: The data of 1173 patients who received RNU for UTUC without neoadjuvant chemotherapy in 11 institutions between 2002 and 2016 were retrospectively reviewed. A matched propensity score analysis was performed. Clinicopathologic variables, recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were compared between patients with pure UTUC and patients with UTUC and VH. Univariate and multivariate Cox proportional regression models were used to determine the independent variables associated with oncologic outcomes. Results: UTUC with VH was observed in 93 patients (7.9%). After propensity score matching, UTUC with VH showed no difference in clinicopathologic features compared to pure UTUC; however, it was associated with shorter RFS, CSS, and OS (log rank, P =.011, P =.002, P =.006, respectively). Additionally, the multivariate analysis revealed that VH was independently associated with a poor RFS [hazard ratio (HR) = 1.92; 95% confidence interval (CI), 1.27-2.89; P =.002], CSS (HR = 4.47; 95% CI, 1.99-10.1; P =.001), and OS (HR = 3.00; 95% CI, 1.55-5.78; P =.001). However, the Kaplan-Meier method revealed that differences in RFS, CSS, and OS were not significant in patients who received adjuvant chemotherapy (log rank, P =.562, P =.060, P =.153, respectively). Conclusion: UTUC with VH was independently associated with poor oncologic outcomes in patients with UTUC after RNU. Although patients with UTUC and VH had a poor prognosis compared to patients with pure UTUC, adjuvant chemotherapy would be helpful in improving the survival rates of these patients. Because of its rarity, reports focusing on patients with upper tract urothelial carcinoma (UTUC) and variant histology (VH) are limited. The current study results suggest that VH is an independent prognostic factor associated with recurrence-free survival, cancer-specific survival, and overall survival in patients with UTUC after radical nephroureterectomy. Although patients with UTUC and VH had a poor prognosis compared to those with pure UTUC, the results suggest that adjuvant chemotherapy could improve oncologic outcomes in these patients.

KW - Histology

KW - Nephroureterectomy

KW - Prognosis

KW - Survival

KW - Urothelium

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U2 - 10.1016/j.clgc.2018.11.015

DO - 10.1016/j.clgc.2018.11.015

M3 - Article

JO - Clinical Genitourinary Cancer

JF - Clinical Genitourinary Cancer

SN - 1558-7673

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