Effects of yeast hydrolysate on hepatic lipid metabolism in high-fat-diet-induced obese mice: Yeast hydrolysate suppresses body fat accumulation by attenuating fatty acid synthesis

Eun Young Jung, Yang Hee Hong, Jae Hwan Kim, Yooheon Park, Song Hwan Bae, Un Jae Chang, Hyung Joo Suh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: We observed whether the anti-obesity activity of yeast hydrolysate (YH) was due to the alteration of lipid-regulating enzyme activities. Methods: Male ICR mice were divided into four groups: a normal diet group (ND; 4.2% fat), a high-fat diet group (HF; 27.7% fat), an HF group treated orally with 0.5% or 1% YH in the drinking water (HF+YH0.5; 27.7% fat and HF+YH1; 27.7% fat). Results: After 5 weeks, the YH groups (HF+YH0.5 = 3.92 ± 0.17 g/100 g BW and HF+YH1 = 3.76 ± 0.13 g/100 g BW) had significantly lower levels of epididymal fats compared to the HF group (4.91 ± 0.29 g/100 g BW; p < 0.05). YH supplementation produced a decrease in serum triglycerides and low-density lipoprotein cholesterol concentrations and body weight gain, and produced a dose-dependent significant increase in serum ghrelin compared with the HF group (p < 0.05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1% YH exhibited a significant decrease in hepatic malic enzyme (ME) activity compared to obese mice treated with the vehicle (HF = 10.44 ± 2.74 nmol/min/mg protein vs. HF+YH1 = 6.68 ± 2.23 nmol/min/mg protein; p < 0.05). Conclusions: YH supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and ME activities.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalAnnals of Nutrition and Metabolism
Volume61
Issue number2
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Obese Mice
High Fat Diet
Lipid Metabolism
Adipose Tissue
Fatty Acids
Yeasts
Liver
Fats
Glucosephosphate Dehydrogenase
Enzymes
Inbred ICR Mouse
Ghrelin
Serum
Drinking Water
LDL Cholesterol
Weight Gain
Triglycerides
Proteins
Down-Regulation
Obesity

Keywords

  • Epididymal fat
  • Ghrelin
  • Glucose-6-phosphate dehydrogenase
  • Malic enzyme
  • Yeast hydrolysate

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of yeast hydrolysate on hepatic lipid metabolism in high-fat-diet-induced obese mice : Yeast hydrolysate suppresses body fat accumulation by attenuating fatty acid synthesis. / Jung, Eun Young; Hong, Yang Hee; Kim, Jae Hwan; Park, Yooheon; Bae, Song Hwan; Chang, Un Jae; Suh, Hyung Joo.

In: Annals of Nutrition and Metabolism, Vol. 61, No. 2, 01.10.2012, p. 89-94.

Research output: Contribution to journalArticle

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abstract = "Aims: We observed whether the anti-obesity activity of yeast hydrolysate (YH) was due to the alteration of lipid-regulating enzyme activities. Methods: Male ICR mice were divided into four groups: a normal diet group (ND; 4.2{\%} fat), a high-fat diet group (HF; 27.7{\%} fat), an HF group treated orally with 0.5{\%} or 1{\%} YH in the drinking water (HF+YH0.5; 27.7{\%} fat and HF+YH1; 27.7{\%} fat). Results: After 5 weeks, the YH groups (HF+YH0.5 = 3.92 ± 0.17 g/100 g BW and HF+YH1 = 3.76 ± 0.13 g/100 g BW) had significantly lower levels of epididymal fats compared to the HF group (4.91 ± 0.29 g/100 g BW; p < 0.05). YH supplementation produced a decrease in serum triglycerides and low-density lipoprotein cholesterol concentrations and body weight gain, and produced a dose-dependent significant increase in serum ghrelin compared with the HF group (p < 0.05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1{\%} YH exhibited a significant decrease in hepatic malic enzyme (ME) activity compared to obese mice treated with the vehicle (HF = 10.44 ± 2.74 nmol/min/mg protein vs. HF+YH1 = 6.68 ± 2.23 nmol/min/mg protein; p < 0.05). Conclusions: YH supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and ME activities.",
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T1 - Effects of yeast hydrolysate on hepatic lipid metabolism in high-fat-diet-induced obese mice

T2 - Yeast hydrolysate suppresses body fat accumulation by attenuating fatty acid synthesis

AU - Jung, Eun Young

AU - Hong, Yang Hee

AU - Kim, Jae Hwan

AU - Park, Yooheon

AU - Bae, Song Hwan

AU - Chang, Un Jae

AU - Suh, Hyung Joo

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N2 - Aims: We observed whether the anti-obesity activity of yeast hydrolysate (YH) was due to the alteration of lipid-regulating enzyme activities. Methods: Male ICR mice were divided into four groups: a normal diet group (ND; 4.2% fat), a high-fat diet group (HF; 27.7% fat), an HF group treated orally with 0.5% or 1% YH in the drinking water (HF+YH0.5; 27.7% fat and HF+YH1; 27.7% fat). Results: After 5 weeks, the YH groups (HF+YH0.5 = 3.92 ± 0.17 g/100 g BW and HF+YH1 = 3.76 ± 0.13 g/100 g BW) had significantly lower levels of epididymal fats compared to the HF group (4.91 ± 0.29 g/100 g BW; p < 0.05). YH supplementation produced a decrease in serum triglycerides and low-density lipoprotein cholesterol concentrations and body weight gain, and produced a dose-dependent significant increase in serum ghrelin compared with the HF group (p < 0.05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1% YH exhibited a significant decrease in hepatic malic enzyme (ME) activity compared to obese mice treated with the vehicle (HF = 10.44 ± 2.74 nmol/min/mg protein vs. HF+YH1 = 6.68 ± 2.23 nmol/min/mg protein; p < 0.05). Conclusions: YH supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and ME activities.

AB - Aims: We observed whether the anti-obesity activity of yeast hydrolysate (YH) was due to the alteration of lipid-regulating enzyme activities. Methods: Male ICR mice were divided into four groups: a normal diet group (ND; 4.2% fat), a high-fat diet group (HF; 27.7% fat), an HF group treated orally with 0.5% or 1% YH in the drinking water (HF+YH0.5; 27.7% fat and HF+YH1; 27.7% fat). Results: After 5 weeks, the YH groups (HF+YH0.5 = 3.92 ± 0.17 g/100 g BW and HF+YH1 = 3.76 ± 0.13 g/100 g BW) had significantly lower levels of epididymal fats compared to the HF group (4.91 ± 0.29 g/100 g BW; p < 0.05). YH supplementation produced a decrease in serum triglycerides and low-density lipoprotein cholesterol concentrations and body weight gain, and produced a dose-dependent significant increase in serum ghrelin compared with the HF group (p < 0.05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1% YH exhibited a significant decrease in hepatic malic enzyme (ME) activity compared to obese mice treated with the vehicle (HF = 10.44 ± 2.74 nmol/min/mg protein vs. HF+YH1 = 6.68 ± 2.23 nmol/min/mg protein; p < 0.05). Conclusions: YH supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and ME activities.

KW - Epididymal fat

KW - Ghrelin

KW - Glucose-6-phosphate dehydrogenase

KW - Malic enzyme

KW - Yeast hydrolysate

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