Efficacy and safety of a newly developed polylactic acid microsphere as an injectable bulking agent for penile augmentation: 18-months follow-up

D. Y. Yang, K. Ko, S. H. Lee, D. G. Moon, J. W. Kim, W. K. Lee

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Polylactic acid (PLA) fillers are widely used for cosmetic volume augmentation. But, no study has evaluated the use of PLA filler in penile augmentation (PA No. 4). We evaluated the efficacy and safety of a newly developed PLA filler for PA during a 18-month follow-up period. A total of 23 healthy adult men were prospectively enrolled between June and November 2012. Penile girth was measured at proximal-, mid- A nd distal-shaft at baseline, 3, 6, 12 and 18 months following injection. Subjects' satisfaction was assessed with visual analogue scale (VAS). Adverse events (AEs) were also reported. Mean injected volume was 20 ml. The circumference of proximal-, mid-, and distal-shaft increased by a mean of 2.2 ± 0.2, 2.7 ± 1.0 and 2.7 ± 1.0 cm at 3 months, respectively (each P<0.001). No significant differences were noted in girth circumference between 3 and 18 months post-injection (each P>0.05). VAS score increased from 51.6 ± 14.7 at baseline to 64.8 ± 19.3 and 74.3 ± 14.6 at 3 and 6 months, respectively (each P<0.05). Six cases of mild, transient treatment-emergent AEs were reported in 5 subjects. Serious AEs were not reported. In conclusion, penile injection of a newly developed PLA filler led to significant penile augmentative effects for up to 18 months and was well tolerated without serious AEs.

    Original languageEnglish
    Pages (from-to)136-141
    Number of pages6
    JournalInternational Journal of Impotence Research
    Volume29
    Issue number4
    DOIs
    Publication statusPublished - 2017 Jul 1

    ASJC Scopus subject areas

    • Urology

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