TY - JOUR
T1 - Efficacy and safety of lobeglitazone monotherapy in patients with type 2 diabetes mellitus over 24-weeks
T2 - A multicenter, randomized, double-blind, parallel-group, placebo controlled trial
AU - Kim, Sin Gon
AU - Kim, Doo Man
AU - Woo, Jeong Taek
AU - Jang, Hak Chul
AU - Chung, Choon Hee
AU - Ko, Kyung Soo
AU - Park, Jeong Hyun
AU - Park, Yong Soo
AU - Kim, Sang Jin
AU - Choi, Dong Seop
N1 - Funding Information:
This study is funded by Chong Kun Dang Pharmaceutical Corp, manufacture of lobeglitazone. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLoS ONE policies on sharing data and materials. The investigators and representatives from Chong Kun Dang were responsible for the study design, protocol, statistical analysis plans, analysis, and reporting of the results. The decision to submit the manuscript for publication was made jointly by all authors.
PY - 2014/4/15
Y1 - 2014/4/15
N2 - Objective: The aim of this study was to assess the glucose-lowering and lipid-modifying effects, and safety profile of lobeglitazone, a novel peroxisome proliferator-activated receptor- c agonist, compared to placebo as a monotherapy in patients with type 2 diabetes. Research Design and Methods: In this 24-week, multicenter, randomized, double-blind, parallel-group, placebo controlled study, 173 patients were randomly assigned (a 2:1 ratio) to lobeglitazone 0.5 mg (n = 115) or matching placebo (n = 58) orally once daily. The primary endpoint was the change in glycated hemoglobin (HbA1c) from baseline to the end of treatment. The secondary endpoints included various glycemic parameters, lipid parameters and safety profile (ClinicalTrials.gov number NCT01001611). Results: At 24 weeks, a significant reduction in HbA1c was observed with lobeglitazone versus placebo (20.44% vs 0.16%, mean difference 20.6%, p,0.0001). The goal of HbA1c ,7% was achieved significantly more in the lobeglitazone group compared to the placebo group (44% vs 12%, p,0.0001). Markers of insulin resistance were also improved in the lobeglitazone group. In addition, lobeglitazone treatment significantly improved triglycerides, high density lipoprotein cholesterol, small dense low density lipoprotein cholesterol, free fatty acid, and apolipoprotein-B/CIII compared to placebo (p,0.01, respectively). More weight gain was observed in the lobeglitazone group than the placebo group (0.89 kg vs - 0.63 kg, mean difference 1.52 kg, p,0.0001). The safety profile was comparable between the two groups and lobeglitazone was well tolerated. Conclusions: Lobeglitazone 0.5 mg showed a favorable balance in the efficacy and safety profile. The results support a potential role of lobeglitazone in treating type 2 diabetes.
AB - Objective: The aim of this study was to assess the glucose-lowering and lipid-modifying effects, and safety profile of lobeglitazone, a novel peroxisome proliferator-activated receptor- c agonist, compared to placebo as a monotherapy in patients with type 2 diabetes. Research Design and Methods: In this 24-week, multicenter, randomized, double-blind, parallel-group, placebo controlled study, 173 patients were randomly assigned (a 2:1 ratio) to lobeglitazone 0.5 mg (n = 115) or matching placebo (n = 58) orally once daily. The primary endpoint was the change in glycated hemoglobin (HbA1c) from baseline to the end of treatment. The secondary endpoints included various glycemic parameters, lipid parameters and safety profile (ClinicalTrials.gov number NCT01001611). Results: At 24 weeks, a significant reduction in HbA1c was observed with lobeglitazone versus placebo (20.44% vs 0.16%, mean difference 20.6%, p,0.0001). The goal of HbA1c ,7% was achieved significantly more in the lobeglitazone group compared to the placebo group (44% vs 12%, p,0.0001). Markers of insulin resistance were also improved in the lobeglitazone group. In addition, lobeglitazone treatment significantly improved triglycerides, high density lipoprotein cholesterol, small dense low density lipoprotein cholesterol, free fatty acid, and apolipoprotein-B/CIII compared to placebo (p,0.01, respectively). More weight gain was observed in the lobeglitazone group than the placebo group (0.89 kg vs - 0.63 kg, mean difference 1.52 kg, p,0.0001). The safety profile was comparable between the two groups and lobeglitazone was well tolerated. Conclusions: Lobeglitazone 0.5 mg showed a favorable balance in the efficacy and safety profile. The results support a potential role of lobeglitazone in treating type 2 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=84899693223&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0092843
DO - 10.1371/journal.pone.0092843
M3 - Article
C2 - 24736628
AN - SCOPUS:84899693223
SN - 1932-6203
VL - 9
JO - PLoS One
JF - PLoS One
IS - 4
M1 - e92843
ER -
