Efficacy and safety of uro-vaxom treatment for patients with recurrent cystitis: An open multicenter study

Seung Ju Lee, Su Jin Kim, Yong Hyun Cho, Young Nam Woo, Bup Wan Kim, Sung Goo Chang, Min Eui Kim, Chul Sung Kim, Jeong Gu Lee, Bong Suck Sim, Hyung Jin Kim, Byung Ha Chung, In Rae Cho, Sang Don Lee

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2 Citations (Scopus)

Abstract

Purpose: We wanted to investigate the efficacy and safety of the immunotherapeutic Uro-Vaxom for treating uncomplicated recurrent cystitis in female patients only. Materials and Methods: Adult female patients were enrolled in this multicenter, open-label study if they had acute cystitis at the enrollment visit and positive results on urine culture (≥103 CFU/ml). The patients were treated for 3 months with one capsule daily of Uro-Vaxom after antibiotic therapy, and they were observed for another 3 months. The primary efficacy criteria were the cystitis recurrence rates over 6 months, the distribution of cystitis and the proportion of patients with cystitis. Results: A total of 50 patients were evaluated. During the 6-month trial, the number of cystitis recurrences was significantly reduced in comparison with the 6-month pretrial period (on the average 0.64 as compared to 3.0 recurrences, respectively p < 0.001). The incidences of frequency, urgency and dysuria remained low until the end of the trial. Uro-Vaxom was well tolerated: side-effects were mentioned by 8% of the 50 patients, and there was no case leading to treatment withdrawal. Conclusions: Uro-Vaxom significantly reduced the incidence of cystitis during the 6 months of this study, including the 3 months of treatment. These results demonstrate that Uro-Vaxom is a valuable agent for prophylaxis of recurrent cystitis.

Original languageEnglish
Pages (from-to)428-432
Number of pages5
JournalKorean Journal of Urology
Volume48
Issue number4
DOIs
Publication statusPublished - 2007 Apr

Keywords

  • Cystitis
  • Escherichia coli
  • Female
  • Uro-Vaxom

ASJC Scopus subject areas

  • Urology

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    Lee, S. J., Kim, S. J., Cho, Y. H., Woo, Y. N., Kim, B. W., Chang, S. G., Kim, M. E., Kim, C. S., Lee, J. G., Sim, B. S., Kim, H. J., Chung, B. H., Cho, I. R., & Lee, S. D. (2007). Efficacy and safety of uro-vaxom treatment for patients with recurrent cystitis: An open multicenter study. Korean Journal of Urology, 48(4), 428-432. https://doi.org/10.4111/kju.2007.48.4.428