Efficacy of 14 day OBMT therapy as a second-line treatment for Helicobacter pylori infection

Sung Chul Park, Hoon-Jai Chun, Sung Woo Jung, Bora Keum, Woo Sik Han, Rok Son Choung, Yong Sik Kim, Yoon Tae Jeen, Hong Sik Lee, Soon-Ho Um, Sang Woo Lee, Jai Hyun Choi, Chang Duck Kim, Ho Sang Ryu, Jin Hai Hyun

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10 Citations (Scopus)

Abstract

BACKGROUND/AIMS: As a second-line treatment for H. pylori eradication in the case of first-line OAC (omeprazole, amoxicillin, clarithromycin) treatment failure, a minimum of one-week OBMT quadruple therapy composed of omeprazole, bismuth, metronidazole, tetracycline has been recommended in European countries and one or two weeks in USA. In Korea, one-week OBMT quadruple therapy is recommended for the case of first-line OAC treatment failure. Because H. pylori eradication rate of one-week OBMT therapy in Korea is about 80%, the eradication rate of one week therapy is not satisfactory. We analyzed the effect of two-week second-line OBMT therapy. METHODS: Between June 2002 and June 2003, 107 patients who were H. pylori positive (44 males and 63 females: mean age 51.8 years) after primary eradication therapy received two-week OBMT therapy. Four weeks after completion of therapy, 13C-urea breath test was performed to detect H. pylori. RESULTS: After two weeks of OBMT therapy, eradication was achieved in 103 of 107 patients (96.3%) and in 68 of 71 peptic ulcer patients (95.8%). CONCLUSIONS: Two-week OBMT therapy should be considered as a retreatment regimen with the eradication rate more than 90%.

Original languageEnglish
Pages (from-to)136-141
Number of pages6
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume44
Issue number3
Publication statusPublished - 2004 Jan 1

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Helicobacter Infections
Helicobacter pylori
Omeprazole
Therapeutics
Clarithromycin
Amoxicillin
Korea
Treatment Failure
Bismuth
Breath Tests
Retreatment
Metronidazole
Tetracycline
Peptic Ulcer
Urea

ASJC Scopus subject areas

  • Medicine(all)

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Efficacy of 14 day OBMT therapy as a second-line treatment for Helicobacter pylori infection. / Park, Sung Chul; Chun, Hoon-Jai; Jung, Sung Woo; Keum, Bora; Han, Woo Sik; Choung, Rok Son; Kim, Yong Sik; Jeen, Yoon Tae; Lee, Hong Sik; Um, Soon-Ho; Lee, Sang Woo; Choi, Jai Hyun; Kim, Chang Duck; Ryu, Ho Sang; Hyun, Jin Hai.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 44, No. 3, 01.01.2004, p. 136-141.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND/AIMS: As a second-line treatment for H. pylori eradication in the case of first-line OAC (omeprazole, amoxicillin, clarithromycin) treatment failure, a minimum of one-week OBMT quadruple therapy composed of omeprazole, bismuth, metronidazole, tetracycline has been recommended in European countries and one or two weeks in USA. In Korea, one-week OBMT quadruple therapy is recommended for the case of first-line OAC treatment failure. Because H. pylori eradication rate of one-week OBMT therapy in Korea is about 80{\%}, the eradication rate of one week therapy is not satisfactory. We analyzed the effect of two-week second-line OBMT therapy. METHODS: Between June 2002 and June 2003, 107 patients who were H. pylori positive (44 males and 63 females: mean age 51.8 years) after primary eradication therapy received two-week OBMT therapy. Four weeks after completion of therapy, 13C-urea breath test was performed to detect H. pylori. RESULTS: After two weeks of OBMT therapy, eradication was achieved in 103 of 107 patients (96.3{\%}) and in 68 of 71 peptic ulcer patients (95.8{\%}). CONCLUSIONS: Two-week OBMT therapy should be considered as a retreatment regimen with the eradication rate more than 90{\%}.",
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AU - Ryu, Ho Sang

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