Efficacy of a dexamethasone-eluting nitinol stent on the inhibition of pseudointimal hyperplasia in a transjugular intrahepatic portosystemic shunt: An experimental study in a swine model

Tae-Seok Seo, Joo Hyeong Oh, Young Koo Park, Ho Young Song, Joon Park Sang, Sun Hong Yuk

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: We wanted to evaluate the feasibility and efficacy of using a dexamethasone (DM)-eluting nitinol stent to inhibit the pseudointimal hyperplasia following stent placement in the transjugular intrahepatic portosystemic shunt tract (TIPS) of a swine. Materials and Methods: Fifteen stents were constructed using 0.15 mm-thick nitinol wire; they were 60 mm in length and 10 mm in diameter. The metallic stents were then classified into three types; type 1 and 2 was coated with the mixture of 12% and 20%, respectively, of DM solution and polyurethane (PU), while type 3 was a bare stent that was used for control study. In fifteen swine, each type of stent was implanted in the TIPS tract of 5 swine, and each animal was sacrificed 2 weeks after TIPS creation. The proliferation of the pseudointima was evaluated both on follow-up portogram and pathologic examination. Results: One TIPS case, using the type 1 stent, and two TIPS cases, using the type 2 stent, maintained their luminal patency while the others were all occluded. On the histopathologic analysis, the mean of the maximum pseudointimal hyperplasia was expressed as the percentage of the stent radius that was patent, and these values were 51.2%, 50% and 76% for the type 1, 2, and 3 stents, respectively. Conclusion: The DM-eluting stent showed a tendency to reduce the development of pseudointimal hyperplasia in the TIPS tract of a swine model with induced-portal hypertension.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalKorean Journal of Radiology
Volume6
Issue number4
DOIs
Publication statusPublished - 2005 Dec 1

Fingerprint

Transjugular Intrahepatic Portasystemic Shunt
Dexamethasone
Hyperplasia
Stents
Swine
nitinol
Polyurethanes
Portal Hypertension

Keywords

  • Experimental Stents and prostheses Shunts
  • Interventional procedures
  • Portosystemic Steroids

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Efficacy of a dexamethasone-eluting nitinol stent on the inhibition of pseudointimal hyperplasia in a transjugular intrahepatic portosystemic shunt : An experimental study in a swine model. / Seo, Tae-Seok; Oh, Joo Hyeong; Park, Young Koo; Song, Ho Young; Sang, Joon Park; Yuk, Sun Hong.

In: Korean Journal of Radiology, Vol. 6, No. 4, 01.12.2005, p. 241-247.

Research output: Contribution to journalArticle

@article{04f482375508495eb994462abd8b28b7,
title = "Efficacy of a dexamethasone-eluting nitinol stent on the inhibition of pseudointimal hyperplasia in a transjugular intrahepatic portosystemic shunt: An experimental study in a swine model",
abstract = "Objective: We wanted to evaluate the feasibility and efficacy of using a dexamethasone (DM)-eluting nitinol stent to inhibit the pseudointimal hyperplasia following stent placement in the transjugular intrahepatic portosystemic shunt tract (TIPS) of a swine. Materials and Methods: Fifteen stents were constructed using 0.15 mm-thick nitinol wire; they were 60 mm in length and 10 mm in diameter. The metallic stents were then classified into three types; type 1 and 2 was coated with the mixture of 12{\%} and 20{\%}, respectively, of DM solution and polyurethane (PU), while type 3 was a bare stent that was used for control study. In fifteen swine, each type of stent was implanted in the TIPS tract of 5 swine, and each animal was sacrificed 2 weeks after TIPS creation. The proliferation of the pseudointima was evaluated both on follow-up portogram and pathologic examination. Results: One TIPS case, using the type 1 stent, and two TIPS cases, using the type 2 stent, maintained their luminal patency while the others were all occluded. On the histopathologic analysis, the mean of the maximum pseudointimal hyperplasia was expressed as the percentage of the stent radius that was patent, and these values were 51.2{\%}, 50{\%} and 76{\%} for the type 1, 2, and 3 stents, respectively. Conclusion: The DM-eluting stent showed a tendency to reduce the development of pseudointimal hyperplasia in the TIPS tract of a swine model with induced-portal hypertension.",
keywords = "Experimental Stents and prostheses Shunts, Interventional procedures, Portosystemic Steroids",
author = "Tae-Seok Seo and Oh, {Joo Hyeong} and Park, {Young Koo} and Song, {Ho Young} and Sang, {Joon Park} and Yuk, {Sun Hong}",
year = "2005",
month = "12",
day = "1",
doi = "10.3348/kjr.2005.6.4.241",
language = "English",
volume = "6",
pages = "241--247",
journal = "Korean Journal of Radiology",
issn = "1229-6929",
publisher = "Korean Radiological Society",
number = "4",

}

TY - JOUR

T1 - Efficacy of a dexamethasone-eluting nitinol stent on the inhibition of pseudointimal hyperplasia in a transjugular intrahepatic portosystemic shunt

T2 - An experimental study in a swine model

AU - Seo, Tae-Seok

AU - Oh, Joo Hyeong

AU - Park, Young Koo

AU - Song, Ho Young

AU - Sang, Joon Park

AU - Yuk, Sun Hong

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Objective: We wanted to evaluate the feasibility and efficacy of using a dexamethasone (DM)-eluting nitinol stent to inhibit the pseudointimal hyperplasia following stent placement in the transjugular intrahepatic portosystemic shunt tract (TIPS) of a swine. Materials and Methods: Fifteen stents were constructed using 0.15 mm-thick nitinol wire; they were 60 mm in length and 10 mm in diameter. The metallic stents were then classified into three types; type 1 and 2 was coated with the mixture of 12% and 20%, respectively, of DM solution and polyurethane (PU), while type 3 was a bare stent that was used for control study. In fifteen swine, each type of stent was implanted in the TIPS tract of 5 swine, and each animal was sacrificed 2 weeks after TIPS creation. The proliferation of the pseudointima was evaluated both on follow-up portogram and pathologic examination. Results: One TIPS case, using the type 1 stent, and two TIPS cases, using the type 2 stent, maintained their luminal patency while the others were all occluded. On the histopathologic analysis, the mean of the maximum pseudointimal hyperplasia was expressed as the percentage of the stent radius that was patent, and these values were 51.2%, 50% and 76% for the type 1, 2, and 3 stents, respectively. Conclusion: The DM-eluting stent showed a tendency to reduce the development of pseudointimal hyperplasia in the TIPS tract of a swine model with induced-portal hypertension.

AB - Objective: We wanted to evaluate the feasibility and efficacy of using a dexamethasone (DM)-eluting nitinol stent to inhibit the pseudointimal hyperplasia following stent placement in the transjugular intrahepatic portosystemic shunt tract (TIPS) of a swine. Materials and Methods: Fifteen stents were constructed using 0.15 mm-thick nitinol wire; they were 60 mm in length and 10 mm in diameter. The metallic stents were then classified into three types; type 1 and 2 was coated with the mixture of 12% and 20%, respectively, of DM solution and polyurethane (PU), while type 3 was a bare stent that was used for control study. In fifteen swine, each type of stent was implanted in the TIPS tract of 5 swine, and each animal was sacrificed 2 weeks after TIPS creation. The proliferation of the pseudointima was evaluated both on follow-up portogram and pathologic examination. Results: One TIPS case, using the type 1 stent, and two TIPS cases, using the type 2 stent, maintained their luminal patency while the others were all occluded. On the histopathologic analysis, the mean of the maximum pseudointimal hyperplasia was expressed as the percentage of the stent radius that was patent, and these values were 51.2%, 50% and 76% for the type 1, 2, and 3 stents, respectively. Conclusion: The DM-eluting stent showed a tendency to reduce the development of pseudointimal hyperplasia in the TIPS tract of a swine model with induced-portal hypertension.

KW - Experimental Stents and prostheses Shunts

KW - Interventional procedures

KW - Portosystemic Steroids

UR - http://www.scopus.com/inward/record.url?scp=31144437134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31144437134&partnerID=8YFLogxK

U2 - 10.3348/kjr.2005.6.4.241

DO - 10.3348/kjr.2005.6.4.241

M3 - Article

C2 - 16374082

AN - SCOPUS:31144437134

VL - 6

SP - 241

EP - 247

JO - Korean Journal of Radiology

JF - Korean Journal of Radiology

SN - 1229-6929

IS - 4

ER -