Efficacy of alpinumisoflavone isolated from maclura tricuspidata fruit in tumor necrosis factor-α-induced damage of human dermal fibroblasts

Sullim Lee, Giang Do Hoang, Daeyoung Kim, Ho Sueb Song, Sungyoul Choi, Dongho Lee, Ki Sung Kang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The skin is an important organ in the human body that protects the body from envi-ronmentally hazardous substances. Reactive oxygen species (ROS) cause inflammatory reactions and degradation of the extracellular matrix leading to skin aging and various cutaneous lesions. This study evaluated the potential of isoflavones isolated from Maclura tricuspidata fruit to pre-vent TNF-α-induced skin inflammation in normal human dermal fibroblasts (HDFs). It focused on alpinumisoflavone (AIF) that suppressed the accumulation of ROS and nitric oxide (NO) in tumor necrosis factor-alpha (TNF-α)-treated HDFs. AIF inhibited the TNF-α-induced increase in matrix metalloproteinase-1, decreased procollagen I α1, and suppressed pro-inflammatory mediators and pro-inflammatory cytokines, including NO synthase, cyclooxygenase-2, interleukin (IL)-1β, IL-6, and IL-8 that trigger inflammatory responses. AIF inhibited nuclear factor-κB and activating protein 1 mitogen-activated protein kinases that were increased by TNF-α stimulation. These results suggest that AIF may protect skin from aging and various cutaneous lesions.

Original languageEnglish
Article number514
JournalAntioxidants
Volume10
Issue number4
DOIs
Publication statusPublished - 2021

Keywords

  • Alpinumisoflavone
  • Human dermal fibroblasts
  • Maclura tricuspidata fruit
  • ROS
  • Skin aging
  • TNF-α

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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