Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study

Eun Hye Han, Mi Kyung Lim, Soyeon Lee, Sang Ho Lee, Su Min Yun, Heui Jong Yu, Seung Ho Ryu, Young Hee Lim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Many natural compounds have been reported to improve cognitive function in cell-and animal-based studies. In this clinical trial, we evaluated the efficacy of ethanolic extract of Opuntia ficus-indica var. saboten stem for improving cognitive function using a randomized, double-blind, placebo-controlled trial (n = 81) in aged people. After 12 weeks of administration of OFE (a mixture of ethanolic extract of O. ficus-indica var. Saboten stem and dextrin) or placebo, the effect on cognitive function was assessed. Overall, OFE did not show a significant difference from the placebo in terms of efficacy. However, the cognitive function significantly improved in the OFE group compared with the placebo group in the subgroup ?70 years of age, which means that the effect of OFE administration exhibits an age-dependent effect. In addition, the safety of OFE was confirmed by analyzing blood test results, vital signs, and electrocardiograms. In conclusion, OFE administration in participants ?70 years of age shows a positive effect on overall cognitive function. The trial was registered on CRIS (the Clinical Research Information Service), administered by the Korea Centers for Disease Control and Prevention (Registration Number: KCT0003766; URL: https://cris.nih.go.kr/cris/en/search/search_result_st01.jsp?seq=12957).

Original languageEnglish
Pages (from-to)1146-1154
Number of pages9
JournalJournal of Medicinal Food
Volume23
Issue number11
DOIs
Publication statusPublished - 2020 Nov 1

Keywords

  • cognitive function
  • double blind
  • Opuntia ficus-indica var. saboten stem
  • placebo-controlled study
  • randomized trial

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study'. Together they form a unique fingerprint.

Cite this