TY - JOUR
T1 - Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age
T2 - A Randomized, Double-Blind, Placebo-Controlled Study
AU - Han, Eun Hye
AU - Lim, Mi Kyung
AU - Lee, Soyeon
AU - Lee, Sang Ho
AU - Yun, Su Min
AU - Yu, Heui Jong
AU - Ryu, Seung Ho
AU - Lim, Young Hee
N1 - Publisher Copyright:
© Copyright 2020, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2020.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Many natural compounds have been reported to improve cognitive function in cell-and animal-based studies. In this clinical trial, we evaluated the efficacy of ethanolic extract of Opuntia ficus-indica var. saboten stem for improving cognitive function using a randomized, double-blind, placebo-controlled trial (n = 81) in aged people. After 12 weeks of administration of OFE (a mixture of ethanolic extract of O. ficus-indica var. Saboten stem and dextrin) or placebo, the effect on cognitive function was assessed. Overall, OFE did not show a significant difference from the placebo in terms of efficacy. However, the cognitive function significantly improved in the OFE group compared with the placebo group in the subgroup ?70 years of age, which means that the effect of OFE administration exhibits an age-dependent effect. In addition, the safety of OFE was confirmed by analyzing blood test results, vital signs, and electrocardiograms. In conclusion, OFE administration in participants ?70 years of age shows a positive effect on overall cognitive function. The trial was registered on CRIS (the Clinical Research Information Service), administered by the Korea Centers for Disease Control and Prevention (Registration Number: KCT0003766; URL: https://cris.nih.go.kr/cris/en/search/search_result_st01.jsp?seq=12957).
AB - Many natural compounds have been reported to improve cognitive function in cell-and animal-based studies. In this clinical trial, we evaluated the efficacy of ethanolic extract of Opuntia ficus-indica var. saboten stem for improving cognitive function using a randomized, double-blind, placebo-controlled trial (n = 81) in aged people. After 12 weeks of administration of OFE (a mixture of ethanolic extract of O. ficus-indica var. Saboten stem and dextrin) or placebo, the effect on cognitive function was assessed. Overall, OFE did not show a significant difference from the placebo in terms of efficacy. However, the cognitive function significantly improved in the OFE group compared with the placebo group in the subgroup ?70 years of age, which means that the effect of OFE administration exhibits an age-dependent effect. In addition, the safety of OFE was confirmed by analyzing blood test results, vital signs, and electrocardiograms. In conclusion, OFE administration in participants ?70 years of age shows a positive effect on overall cognitive function. The trial was registered on CRIS (the Clinical Research Information Service), administered by the Korea Centers for Disease Control and Prevention (Registration Number: KCT0003766; URL: https://cris.nih.go.kr/cris/en/search/search_result_st01.jsp?seq=12957).
KW - cognitive function
KW - double blind
KW - Opuntia ficus-indica var. saboten stem
KW - placebo-controlled study
KW - randomized trial
UR - http://www.scopus.com/inward/record.url?scp=85094628970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094628970&partnerID=8YFLogxK
U2 - 10.1089/jmf.2019.4678
DO - 10.1089/jmf.2019.4678
M3 - Article
C2 - 33006504
AN - SCOPUS:85094628970
VL - 23
SP - 1146
EP - 1154
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
SN - 1096-620X
IS - 11
ER -