Efficacy of flubendazole and albendazole against trichinella spiralis in mice

M. S. Chung, K. H. Joo, F. S. Quan, H. S. Kwon, Sung-Weon Cho

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Efficacy of flubendazole and albendazole against Trichinella spiralis in mice were studied. ICR mice were experimentally infected with Trichinella spiralis and treated with either flubendazole (FBZ) or albendazole (ABZ) at four different stages of the parasite life-cycle. Oral administration of either FBZ or ABZ at 20 mg/kg and 50 mg/kg on 2 h, 8 h and 24 h (pre-adult stage) after infection eliminated 94.7 ˜ 100 % of adults as determined at necropsy on day 7 post infection (p.i.) and 96.9 ˜ 100 % of larvae on day 45 p.i. FBZ was more effective than ABZ against adult T. spiralis (at 2 to 6 days p.i.), when treated with a dosage of 20 mg/kg for 5 consecutive days (99.4 % and 46.0 % reduction with respect to the control group). Against migrating larval T. spiralis, FBZ was more effective than ABZ at 20 mg/kg for five consecutive days (on days 11.15 p.i.), and the reduction rate of recovered larvae were 99.6 % (FBZ) and 80.8 % (ABZ) respectively. FBZ was more effective against early encapsulated larval T. spiralis (at 21 to 25 days p.i.), than ABZ when both were given at 20 mg/kg for five consecutive days (99.8 % and 45.4 % reduction, respectively). In conclusion, flubendazole was more effective than albendazole against adult and parenteral stages of Trichinella spiralis in mice.

Original languageEnglish
Pages (from-to)S195-S198
JournalParasite
Volume8
DOIs
Publication statusPublished - 2001 Jan 1

Fingerprint

flubendazole
Trichinella spiralis
Albendazole
albendazole
mice
Infection
infection
Larva
Inbred ICR Mouse
larvae
Life Cycle Stages
oral administration
Oral Administration
life cycle (organisms)
necropsy
Parasites
parasites

Keywords

  • Albendazole
  • Efficacy
  • Flubendazole
  • Mice
  • Trichinella spiralis

ASJC Scopus subject areas

  • Parasitology
  • Agricultural and Biological Sciences(all)

Cite this

Efficacy of flubendazole and albendazole against trichinella spiralis in mice. / Chung, M. S.; Joo, K. H.; Quan, F. S.; Kwon, H. S.; Cho, Sung-Weon.

In: Parasite, Vol. 8, 01.01.2001, p. S195-S198.

Research output: Contribution to journalArticle

Chung, M. S. ; Joo, K. H. ; Quan, F. S. ; Kwon, H. S. ; Cho, Sung-Weon. / Efficacy of flubendazole and albendazole against trichinella spiralis in mice. In: Parasite. 2001 ; Vol. 8. pp. S195-S198.
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abstract = "Efficacy of flubendazole and albendazole against Trichinella spiralis in mice were studied. ICR mice were experimentally infected with Trichinella spiralis and treated with either flubendazole (FBZ) or albendazole (ABZ) at four different stages of the parasite life-cycle. Oral administration of either FBZ or ABZ at 20 mg/kg and 50 mg/kg on 2 h, 8 h and 24 h (pre-adult stage) after infection eliminated 94.7 ˜ 100 {\%} of adults as determined at necropsy on day 7 post infection (p.i.) and 96.9 ˜ 100 {\%} of larvae on day 45 p.i. FBZ was more effective than ABZ against adult T. spiralis (at 2 to 6 days p.i.), when treated with a dosage of 20 mg/kg for 5 consecutive days (99.4 {\%} and 46.0 {\%} reduction with respect to the control group). Against migrating larval T. spiralis, FBZ was more effective than ABZ at 20 mg/kg for five consecutive days (on days 11.15 p.i.), and the reduction rate of recovered larvae were 99.6 {\%} (FBZ) and 80.8 {\%} (ABZ) respectively. FBZ was more effective against early encapsulated larval T. spiralis (at 21 to 25 days p.i.), than ABZ when both were given at 20 mg/kg for five consecutive days (99.8 {\%} and 45.4 {\%} reduction, respectively). In conclusion, flubendazole was more effective than albendazole against adult and parenteral stages of Trichinella spiralis in mice.",
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AB - Efficacy of flubendazole and albendazole against Trichinella spiralis in mice were studied. ICR mice were experimentally infected with Trichinella spiralis and treated with either flubendazole (FBZ) or albendazole (ABZ) at four different stages of the parasite life-cycle. Oral administration of either FBZ or ABZ at 20 mg/kg and 50 mg/kg on 2 h, 8 h and 24 h (pre-adult stage) after infection eliminated 94.7 ˜ 100 % of adults as determined at necropsy on day 7 post infection (p.i.) and 96.9 ˜ 100 % of larvae on day 45 p.i. FBZ was more effective than ABZ against adult T. spiralis (at 2 to 6 days p.i.), when treated with a dosage of 20 mg/kg for 5 consecutive days (99.4 % and 46.0 % reduction with respect to the control group). Against migrating larval T. spiralis, FBZ was more effective than ABZ at 20 mg/kg for five consecutive days (on days 11.15 p.i.), and the reduction rate of recovered larvae were 99.6 % (FBZ) and 80.8 % (ABZ) respectively. FBZ was more effective against early encapsulated larval T. spiralis (at 21 to 25 days p.i.), than ABZ when both were given at 20 mg/kg for five consecutive days (99.8 % and 45.4 % reduction, respectively). In conclusion, flubendazole was more effective than albendazole against adult and parenteral stages of Trichinella spiralis in mice.

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