Efficacy of Helicobacter pylori eradication for the prevention of metachronous gastric cancer after endoscopic resection for early gastric cancer

Jae Young Jang, Hoon-Jai Chun

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori) plays an important role in gastric carcinogenesis, as the majority of gastric cancers develop from H. pylori-infected gastric mucosa. The rate of early gastric cancer diagnosis has increased in Japan and Korea, where H. pylori infection and gastric cancer are highly prevalent. Early intestinal-type gastric cancer without concomitant lymph node metastasis is usually treated by endoscopic resection. Secondary metachronous gastric cancers often develop because atrophic mucosa left untreated after endoscopic treatment confers a high risk of gastric cancer. The efficacy of H. pylori eradication for the prevention of metachronous gastric cancer remains controversial. However, in patients who undergo endoscopic resection of early gastric cancer, H. pylori eradication is recommended to suppress or delay metachronous gastric cancer. Careful and regularly scheduled endoscopy should be performed to detect minute metachronous gastric cancer after endoscopic resection.

Original languageEnglish
Pages (from-to)2760-2764
Number of pages5
JournalWorld Journal of Gastroenterology
Volume20
Issue number11
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Helicobacter pylori
Stomach Neoplasms
Intestinal Neoplasms
Helicobacter Infections
Korea
Gastric Mucosa
Early Detection of Cancer
Endoscopy
Stomach
Japan
Carcinogenesis
Mucous Membrane
Lymph Nodes
Neoplasm Metastasis

Keywords

  • Endoscopic resection
  • Gastric cancer
  • Helicobacter pylori
  • Metachronous cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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abstract = "Helicobacter pylori (H. pylori) plays an important role in gastric carcinogenesis, as the majority of gastric cancers develop from H. pylori-infected gastric mucosa. The rate of early gastric cancer diagnosis has increased in Japan and Korea, where H. pylori infection and gastric cancer are highly prevalent. Early intestinal-type gastric cancer without concomitant lymph node metastasis is usually treated by endoscopic resection. Secondary metachronous gastric cancers often develop because atrophic mucosa left untreated after endoscopic treatment confers a high risk of gastric cancer. The efficacy of H. pylori eradication for the prevention of metachronous gastric cancer remains controversial. However, in patients who undergo endoscopic resection of early gastric cancer, H. pylori eradication is recommended to suppress or delay metachronous gastric cancer. Careful and regularly scheduled endoscopy should be performed to detect minute metachronous gastric cancer after endoscopic resection.",
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