Efficacy of itraconazole melt-extrusion tablet one-week therapy in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus

Chan Moon Kee Chan Moon, Kyoung Koh Jai Kyoung Koh, Kee Cho Baik Kee Cho, Ok Kim Hyung Ok Kim, Su Park Gun Su Park, Gyoo Byun Dae Gyoo Byun, Wou Kim Jin Wou Kim, Gang Jang In Gang Jang, Yuk Yi Jong Yuk Yi, Bok Jun Jae Bok Jun, Jin Yoon Tae Jin Yoon, In Kim Nack In Kim, Suk Lee Kyu Suk Lee, Chil Hwan Oh, Nam Kim Soo Nam Kim, Ja Son Sook Ja Son, Woo Cinn Yong Woo Cinn, Seok Kim Dong Seok Kim, Yeol Cho Kwang Yeol Cho, Woo Lee Won Woo Lee & 33 others Sool Kwon Kyung Sool Kwon, Hun Suh Dae Hun Suh, Eun Moon Sang Eun Moon, Ryong Park See Ryong Park, Jeung Kim Kea Jeung Kim, Suk Lee Jong Suk Lee, So Lee Eun So Lee, Joo Choi Hyun Joo Choi, Ho Choi Eung Ho Choi, Hong Kim Ki Hong Kim, Hoon Cha Seung Hoon Cha, Gull Kim Young Gull Kim, Hee Hahm Jeong Hee Hahm, Young Choi Hae Young Choi, Wook Park Sung Wook Park, Soon Kim Bang Soon Kim, Wahn Koo Sang Wahn Koo, Su Kim Byung Su Kim, Ho Won Young Ho Won, Uk Kim Han Uk Kim, Sup Song Eun Sup Song, Soo Chung Byoung Soo Chung, In Ro Byung In Ro, Kwun Hong Chang Kwun Hong, Kyu Park Jang Kyu Park, Young Yoon Tae Young Yoon, Sung Kim Hee Sung Kim, Heon Lee Cheol Heon Lee, Joong Kim Kwang Joong Kim, Won Koo Dae Won Koo, Min Kim Jong Min Kim, Woo Lee Chang Woo Lee, Joon Yu Hee Joon Yu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Backgrounds: Since the bioavailability of itraconazole capsule is influenced by patients gastric acidity, it results in treatment failure due to its low dissolution and subsequent low absorption when administered in fasting. Itraconazole Melt-Extrusion tablet has been lately developed in order to improve its dissolution profile. It is the first clinical study to evaluate the efficacy and safety of itraconazole Melt-Extrusion tablet in Korea. Objective: This study was conducted to evaluate the efficacy and safety of itraconazole melt-extrusion tablet 400mg daily for 1 week(pulse therapy) for hyperkeratotic type of tinea pedis and manus. Methods: A clinical and mycological investigation was made of 812 outpatients with hyperkeratotic type of tinea pedis and/or tinea manus who had visited at 52 general hospitals under the lead of the Korean Dermatological Association from June to December, 1998. Patients confirmed by clinically and microscopically as hyperkeratotic type of tinea pedis and/or tinea manus were administered 2 tablets twice a day for one week and followed up for 8 weeks from the start of the medication. Results: The results were summarized as follows; 1. Clinical symptoms of hyperkeratotic type of tinea pedis and/or tinea manus were significantly improved at the end of study, week 8(p<0.001). 2. Clinical response rate, defined as more than 50% decrease of the sum of the clinical symptom scores, was 79.3%(512/646). 3. Mycological cure rate, defined as both culture and KOH negative at week 8, was 78.2%(244/312). 4. 40(5.5%) patients, of the 727 patients evaluable for drug safety evaluation, were reported to have adverse event. Conclusion: Itraconazole Melt-Extrusion tablet 400mg/day for 1 week (pulse therapy) is effective and safe in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus.

Original languageEnglish
Pages (from-to)1047-1056
Number of pages10
JournalKorean Journal of Dermatology
Volume37
Issue number8
Publication statusPublished - 1999 Nov 22
Externally publishedYes

Fingerprint

Tinea Pedis
Tinea
Itraconazole
Tablets
Safety
Therapeutics
Drug Evaluation
Korea
Treatment Failure
General Hospitals
Biological Availability
Capsules
Fasting
Stomach
Outpatients

Keywords

  • Itraconazole melt-extrusion tablet
  • Pulse therapy
  • Tinea manus
  • Tinea pedis

ASJC Scopus subject areas

  • Dermatology

Cite this

Kee Chan Moon, C. M., Jai Kyoung Koh, K. K., Baik Kee Cho, K. C., Hyung Ok Kim, O. K., Gun Su Park, S. P., Dae Gyoo Byun, G. B., ... Hee Joon Yu, J. Y. (1999). Efficacy of itraconazole melt-extrusion tablet one-week therapy in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus. Korean Journal of Dermatology, 37(8), 1047-1056.

Efficacy of itraconazole melt-extrusion tablet one-week therapy in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus. / Kee Chan Moon, Chan Moon; Jai Kyoung Koh, Kyoung Koh; Baik Kee Cho, Kee Cho; Hyung Ok Kim, Ok Kim; Gun Su Park, Su Park; Dae Gyoo Byun, Gyoo Byun; Jin Wou Kim, Wou Kim; In Gang Jang, Gang Jang; Jong Yuk Yi, Yuk Yi; Jae Bok Jun, Bok Jun; Tae Jin Yoon, Jin Yoon; Nack In Kim, In Kim; Kyu Suk Lee, Suk Lee; Oh, Chil Hwan; Soo Nam Kim, Nam Kim; Sook Ja Son, Ja Son; Yong Woo Cinn, Woo Cinn; Dong Seok Kim, Seok Kim; Kwang Yeol Cho, Yeol Cho; Won Woo Lee, Woo Lee; Kyung Sool Kwon, Sool Kwon; Dae Hun Suh, Hun Suh; Sang Eun Moon, Eun Moon; See Ryong Park, Ryong Park; Kea Jeung Kim, Jeung Kim; Jong Suk Lee, Suk Lee; Eun So Lee, So Lee; Hyun Joo Choi, Joo Choi; Eung Ho Choi, Ho Choi; Ki Hong Kim, Hong Kim; Seung Hoon Cha, Hoon Cha; Young Gull Kim, Gull Kim; Jeong Hee Hahm, Hee Hahm; Hae Young Choi, Young Choi; Sung Wook Park, Wook Park; Bang Soon Kim, Soon Kim; Sang Wahn Koo, Wahn Koo; Byung Su Kim, Su Kim; Young Ho Won, Ho Won; Han Uk Kim, Uk Kim; Eun Sup Song, Sup Song; Byoung Soo Chung, Soo Chung; Byung In Ro, In Ro; Chang Kwun Hong, Kwun Hong; Jang Kyu Park, Kyu Park; Tae Young Yoon, Young Yoon; Hee Sung Kim, Sung Kim; Cheol Heon Lee, Heon Lee; Kwang Joong Kim, Joong Kim; Dae Won Koo, Won Koo; Jong Min Kim, Min Kim; Chang Woo Lee, Woo Lee; Hee Joon Yu, Joon Yu.

In: Korean Journal of Dermatology, Vol. 37, No. 8, 22.11.1999, p. 1047-1056.

Research output: Contribution to journalArticle

Kee Chan Moon, CM, Jai Kyoung Koh, KK, Baik Kee Cho, KC, Hyung Ok Kim, OK, Gun Su Park, SP, Dae Gyoo Byun, GB, Jin Wou Kim, WK, In Gang Jang, GJ, Jong Yuk Yi, YY, Jae Bok Jun, BJ, Tae Jin Yoon, JY, Nack In Kim, IK, Kyu Suk Lee, SL, Oh, CH, Soo Nam Kim, NK, Sook Ja Son, JS, Yong Woo Cinn, WC, Dong Seok Kim, SK, Kwang Yeol Cho, YC, Won Woo Lee, WL, Kyung Sool Kwon, SK, Dae Hun Suh, HS, Sang Eun Moon, EM, See Ryong Park, RP, Kea Jeung Kim, JK, Jong Suk Lee, SL, Eun So Lee, SL, Hyun Joo Choi, JC, Eung Ho Choi, HC, Ki Hong Kim, HK, Seung Hoon Cha, HC, Young Gull Kim, GK, Jeong Hee Hahm, HH, Hae Young Choi, YC, Sung Wook Park, WP, Bang Soon Kim, SK, Sang Wahn Koo, WK, Byung Su Kim, SK, Young Ho Won, HW, Han Uk Kim, UK, Eun Sup Song, SS, Byoung Soo Chung, SC, Byung In Ro, IR, Chang Kwun Hong, KH, Jang Kyu Park, KP, Tae Young Yoon, YY, Hee Sung Kim, SK, Cheol Heon Lee, HL, Kwang Joong Kim, JK, Dae Won Koo, WK, Jong Min Kim, MK, Chang Woo Lee, WL & Hee Joon Yu, JY 1999, 'Efficacy of itraconazole melt-extrusion tablet one-week therapy in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus', Korean Journal of Dermatology, vol. 37, no. 8, pp. 1047-1056.
Kee Chan Moon CM, Jai Kyoung Koh KK, Baik Kee Cho KC, Hyung Ok Kim OK, Gun Su Park SP, Dae Gyoo Byun GB et al. Efficacy of itraconazole melt-extrusion tablet one-week therapy in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus. Korean Journal of Dermatology. 1999 Nov 22;37(8):1047-1056.
Kee Chan Moon, Chan Moon ; Jai Kyoung Koh, Kyoung Koh ; Baik Kee Cho, Kee Cho ; Hyung Ok Kim, Ok Kim ; Gun Su Park, Su Park ; Dae Gyoo Byun, Gyoo Byun ; Jin Wou Kim, Wou Kim ; In Gang Jang, Gang Jang ; Jong Yuk Yi, Yuk Yi ; Jae Bok Jun, Bok Jun ; Tae Jin Yoon, Jin Yoon ; Nack In Kim, In Kim ; Kyu Suk Lee, Suk Lee ; Oh, Chil Hwan ; Soo Nam Kim, Nam Kim ; Sook Ja Son, Ja Son ; Yong Woo Cinn, Woo Cinn ; Dong Seok Kim, Seok Kim ; Kwang Yeol Cho, Yeol Cho ; Won Woo Lee, Woo Lee ; Kyung Sool Kwon, Sool Kwon ; Dae Hun Suh, Hun Suh ; Sang Eun Moon, Eun Moon ; See Ryong Park, Ryong Park ; Kea Jeung Kim, Jeung Kim ; Jong Suk Lee, Suk Lee ; Eun So Lee, So Lee ; Hyun Joo Choi, Joo Choi ; Eung Ho Choi, Ho Choi ; Ki Hong Kim, Hong Kim ; Seung Hoon Cha, Hoon Cha ; Young Gull Kim, Gull Kim ; Jeong Hee Hahm, Hee Hahm ; Hae Young Choi, Young Choi ; Sung Wook Park, Wook Park ; Bang Soon Kim, Soon Kim ; Sang Wahn Koo, Wahn Koo ; Byung Su Kim, Su Kim ; Young Ho Won, Ho Won ; Han Uk Kim, Uk Kim ; Eun Sup Song, Sup Song ; Byoung Soo Chung, Soo Chung ; Byung In Ro, In Ro ; Chang Kwun Hong, Kwun Hong ; Jang Kyu Park, Kyu Park ; Tae Young Yoon, Young Yoon ; Hee Sung Kim, Sung Kim ; Cheol Heon Lee, Heon Lee ; Kwang Joong Kim, Joong Kim ; Dae Won Koo, Won Koo ; Jong Min Kim, Min Kim ; Chang Woo Lee, Woo Lee ; Hee Joon Yu, Joon Yu. / Efficacy of itraconazole melt-extrusion tablet one-week therapy in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus. In: Korean Journal of Dermatology. 1999 ; Vol. 37, No. 8. pp. 1047-1056.
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title = "Efficacy of itraconazole melt-extrusion tablet one-week therapy in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus",
abstract = "Backgrounds: Since the bioavailability of itraconazole capsule is influenced by patients gastric acidity, it results in treatment failure due to its low dissolution and subsequent low absorption when administered in fasting. Itraconazole Melt-Extrusion tablet has been lately developed in order to improve its dissolution profile. It is the first clinical study to evaluate the efficacy and safety of itraconazole Melt-Extrusion tablet in Korea. Objective: This study was conducted to evaluate the efficacy and safety of itraconazole melt-extrusion tablet 400mg daily for 1 week(pulse therapy) for hyperkeratotic type of tinea pedis and manus. Methods: A clinical and mycological investigation was made of 812 outpatients with hyperkeratotic type of tinea pedis and/or tinea manus who had visited at 52 general hospitals under the lead of the Korean Dermatological Association from June to December, 1998. Patients confirmed by clinically and microscopically as hyperkeratotic type of tinea pedis and/or tinea manus were administered 2 tablets twice a day for one week and followed up for 8 weeks from the start of the medication. Results: The results were summarized as follows; 1. Clinical symptoms of hyperkeratotic type of tinea pedis and/or tinea manus were significantly improved at the end of study, week 8(p<0.001). 2. Clinical response rate, defined as more than 50{\%} decrease of the sum of the clinical symptom scores, was 79.3{\%}(512/646). 3. Mycological cure rate, defined as both culture and KOH negative at week 8, was 78.2{\%}(244/312). 4. 40(5.5{\%}) patients, of the 727 patients evaluable for drug safety evaluation, were reported to have adverse event. Conclusion: Itraconazole Melt-Extrusion tablet 400mg/day for 1 week (pulse therapy) is effective and safe in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus.",
keywords = "Itraconazole melt-extrusion tablet, Pulse therapy, Tinea manus, Tinea pedis",
author = "{Kee Chan Moon}, {Chan Moon} and {Jai Kyoung Koh}, {Kyoung Koh} and {Baik Kee Cho}, {Kee Cho} and {Hyung Ok Kim}, {Ok Kim} and {Gun Su Park}, {Su Park} and {Dae Gyoo Byun}, {Gyoo Byun} and {Jin Wou Kim}, {Wou Kim} and {In Gang Jang}, {Gang Jang} and {Jong Yuk Yi}, {Yuk Yi} and {Jae Bok Jun}, {Bok Jun} and {Tae Jin Yoon}, {Jin Yoon} and {Nack In Kim}, {In Kim} and {Kyu Suk Lee}, {Suk Lee} and Oh, {Chil Hwan} and {Soo Nam Kim}, {Nam Kim} and {Sook Ja Son}, {Ja Son} and {Yong Woo Cinn}, {Woo Cinn} and {Dong Seok Kim}, {Seok Kim} and {Kwang Yeol Cho}, {Yeol Cho} and {Won Woo Lee}, {Woo Lee} and {Kyung Sool Kwon}, {Sool Kwon} and {Dae Hun Suh}, {Hun Suh} and {Sang Eun Moon}, {Eun Moon} and {See Ryong Park}, {Ryong Park} and {Kea Jeung Kim}, {Jeung Kim} and {Jong Suk Lee}, {Suk Lee} and {Eun So Lee}, {So Lee} and {Hyun Joo Choi}, {Joo Choi} and {Eung Ho Choi}, {Ho Choi} and {Ki Hong Kim}, {Hong Kim} and {Seung Hoon Cha}, {Hoon Cha} and {Young Gull Kim}, {Gull Kim} and {Jeong Hee Hahm}, {Hee Hahm} and {Hae Young Choi}, {Young Choi} and {Sung Wook Park}, {Wook Park} and {Bang Soon Kim}, {Soon Kim} and {Sang Wahn Koo}, {Wahn Koo} and {Byung Su Kim}, {Su Kim} and {Young Ho Won}, {Ho Won} and {Han Uk Kim}, {Uk Kim} and {Eun Sup Song}, {Sup Song} and {Byoung Soo Chung}, {Soo Chung} and {Byung In Ro}, {In Ro} and {Chang Kwun Hong}, {Kwun Hong} and {Jang Kyu Park}, {Kyu Park} and {Tae Young Yoon}, {Young Yoon} and {Hee Sung Kim}, {Sung Kim} and {Cheol Heon Lee}, {Heon Lee} and {Kwang Joong Kim}, {Joong Kim} and {Dae Won Koo}, {Won Koo} and {Jong Min Kim}, {Min Kim} and {Chang Woo Lee}, {Woo Lee} and {Hee Joon Yu}, {Joon Yu}",
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TY - JOUR

T1 - Efficacy of itraconazole melt-extrusion tablet one-week therapy in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus

AU - Kee Chan Moon, Chan Moon

AU - Jai Kyoung Koh, Kyoung Koh

AU - Baik Kee Cho, Kee Cho

AU - Hyung Ok Kim, Ok Kim

AU - Gun Su Park, Su Park

AU - Dae Gyoo Byun, Gyoo Byun

AU - Jin Wou Kim, Wou Kim

AU - In Gang Jang, Gang Jang

AU - Jong Yuk Yi, Yuk Yi

AU - Jae Bok Jun, Bok Jun

AU - Tae Jin Yoon, Jin Yoon

AU - Nack In Kim, In Kim

AU - Kyu Suk Lee, Suk Lee

AU - Oh, Chil Hwan

AU - Soo Nam Kim, Nam Kim

AU - Sook Ja Son, Ja Son

AU - Yong Woo Cinn, Woo Cinn

AU - Dong Seok Kim, Seok Kim

AU - Kwang Yeol Cho, Yeol Cho

AU - Won Woo Lee, Woo Lee

AU - Kyung Sool Kwon, Sool Kwon

AU - Dae Hun Suh, Hun Suh

AU - Sang Eun Moon, Eun Moon

AU - See Ryong Park, Ryong Park

AU - Kea Jeung Kim, Jeung Kim

AU - Jong Suk Lee, Suk Lee

AU - Eun So Lee, So Lee

AU - Hyun Joo Choi, Joo Choi

AU - Eung Ho Choi, Ho Choi

AU - Ki Hong Kim, Hong Kim

AU - Seung Hoon Cha, Hoon Cha

AU - Young Gull Kim, Gull Kim

AU - Jeong Hee Hahm, Hee Hahm

AU - Hae Young Choi, Young Choi

AU - Sung Wook Park, Wook Park

AU - Bang Soon Kim, Soon Kim

AU - Sang Wahn Koo, Wahn Koo

AU - Byung Su Kim, Su Kim

AU - Young Ho Won, Ho Won

AU - Han Uk Kim, Uk Kim

AU - Eun Sup Song, Sup Song

AU - Byoung Soo Chung, Soo Chung

AU - Byung In Ro, In Ro

AU - Chang Kwun Hong, Kwun Hong

AU - Jang Kyu Park, Kyu Park

AU - Tae Young Yoon, Young Yoon

AU - Hee Sung Kim, Sung Kim

AU - Cheol Heon Lee, Heon Lee

AU - Kwang Joong Kim, Joong Kim

AU - Dae Won Koo, Won Koo

AU - Jong Min Kim, Min Kim

AU - Chang Woo Lee, Woo Lee

AU - Hee Joon Yu, Joon Yu

PY - 1999/11/22

Y1 - 1999/11/22

N2 - Backgrounds: Since the bioavailability of itraconazole capsule is influenced by patients gastric acidity, it results in treatment failure due to its low dissolution and subsequent low absorption when administered in fasting. Itraconazole Melt-Extrusion tablet has been lately developed in order to improve its dissolution profile. It is the first clinical study to evaluate the efficacy and safety of itraconazole Melt-Extrusion tablet in Korea. Objective: This study was conducted to evaluate the efficacy and safety of itraconazole melt-extrusion tablet 400mg daily for 1 week(pulse therapy) for hyperkeratotic type of tinea pedis and manus. Methods: A clinical and mycological investigation was made of 812 outpatients with hyperkeratotic type of tinea pedis and/or tinea manus who had visited at 52 general hospitals under the lead of the Korean Dermatological Association from June to December, 1998. Patients confirmed by clinically and microscopically as hyperkeratotic type of tinea pedis and/or tinea manus were administered 2 tablets twice a day for one week and followed up for 8 weeks from the start of the medication. Results: The results were summarized as follows; 1. Clinical symptoms of hyperkeratotic type of tinea pedis and/or tinea manus were significantly improved at the end of study, week 8(p<0.001). 2. Clinical response rate, defined as more than 50% decrease of the sum of the clinical symptom scores, was 79.3%(512/646). 3. Mycological cure rate, defined as both culture and KOH negative at week 8, was 78.2%(244/312). 4. 40(5.5%) patients, of the 727 patients evaluable for drug safety evaluation, were reported to have adverse event. Conclusion: Itraconazole Melt-Extrusion tablet 400mg/day for 1 week (pulse therapy) is effective and safe in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus.

AB - Backgrounds: Since the bioavailability of itraconazole capsule is influenced by patients gastric acidity, it results in treatment failure due to its low dissolution and subsequent low absorption when administered in fasting. Itraconazole Melt-Extrusion tablet has been lately developed in order to improve its dissolution profile. It is the first clinical study to evaluate the efficacy and safety of itraconazole Melt-Extrusion tablet in Korea. Objective: This study was conducted to evaluate the efficacy and safety of itraconazole melt-extrusion tablet 400mg daily for 1 week(pulse therapy) for hyperkeratotic type of tinea pedis and manus. Methods: A clinical and mycological investigation was made of 812 outpatients with hyperkeratotic type of tinea pedis and/or tinea manus who had visited at 52 general hospitals under the lead of the Korean Dermatological Association from June to December, 1998. Patients confirmed by clinically and microscopically as hyperkeratotic type of tinea pedis and/or tinea manus were administered 2 tablets twice a day for one week and followed up for 8 weeks from the start of the medication. Results: The results were summarized as follows; 1. Clinical symptoms of hyperkeratotic type of tinea pedis and/or tinea manus were significantly improved at the end of study, week 8(p<0.001). 2. Clinical response rate, defined as more than 50% decrease of the sum of the clinical symptom scores, was 79.3%(512/646). 3. Mycological cure rate, defined as both culture and KOH negative at week 8, was 78.2%(244/312). 4. 40(5.5%) patients, of the 727 patients evaluable for drug safety evaluation, were reported to have adverse event. Conclusion: Itraconazole Melt-Extrusion tablet 400mg/day for 1 week (pulse therapy) is effective and safe in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus.

KW - Itraconazole melt-extrusion tablet

KW - Pulse therapy

KW - Tinea manus

KW - Tinea pedis

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M3 - Article

VL - 37

SP - 1047

EP - 1056

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

IS - 8

ER -