Efficacy of para-aortic lymphadenectomy in early-stage endometrioid uterine corpus cancer

Seo Yun Tong, Jong Min Lee, Jae Kwan Lee, Jae Weon Kim, Chi Heum Cho, Seok Mo Kim, Sang Yoon Park, Chan Yong Park, Ki Tae Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: The objective of this study was to assess whether para-aortic lymphadenectomy has therapeutic efficacy for patients with early-stage endometrioid uterine cancer who underwent systematic pelvic lymphadenectomy. Methods: The authors retrospectively reviewed the medical records and pathological findings of 547 patients with histologically proven FIGO stage I-II endometrioid uterine cancer, based on comprehensive surgical staging, including pelvic with or without para-aortic lymphadenectomy. Results: Among 547 patients, 330 patients had systematic pelvic lymphadenectomy only, and 217 had systematic pelvic with para-aortic lymphadenectomy. There were no significant differences in histopathological factors in the high-risk group, even though deep myometrial invasion (p = 0.02) and lymphvascular space invasion (p = 0.01) were more common in patients who underwent systematic pelvic with para-aortic lymphadenectomy in all study populations. Within a median follow-up of 31 (range, 5-120) months, there was no significant difference in overall survival between the pelvic lymphadenectomy only and pelvic with para-aortic lymphadenectomy groups in all populations (p = 0.77), even in high-risk patients (p = 0.82). Upon multivariate analysis, patients with lymphvascular space invasion had significantly worse overall survival (odds ratio (OR) = 7.38; 95% confidence interval (CI) = 1.86-29.23; p = 0.004). Conclusions: Although a prospective, randomized study needs to be performed for confirmation, our data suggest that the therapeutic benefit of para-aortic lymphadenectomy is uncertain in stage I and II endometrioid uterine corpus cancer, even in patients at high-risk for recurrence.

Original languageEnglish
Pages (from-to)1425-1430
Number of pages6
JournalAnnals of Surgical Oncology
Volume18
Issue number5
DOIs
Publication statusPublished - 2011 May 1

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Uterine Neoplasms
Lymph Node Excision
Survival
Population
Medical Records
Multivariate Analysis
Odds Ratio
Prospective Studies
Confidence Intervals
Recurrence

ASJC Scopus subject areas

  • Surgery
  • Oncology

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Efficacy of para-aortic lymphadenectomy in early-stage endometrioid uterine corpus cancer. / Tong, Seo Yun; Lee, Jong Min; Lee, Jae Kwan; Kim, Jae Weon; Cho, Chi Heum; Kim, Seok Mo; Park, Sang Yoon; Park, Chan Yong; Kim, Ki Tae.

In: Annals of Surgical Oncology, Vol. 18, No. 5, 01.05.2011, p. 1425-1430.

Research output: Contribution to journalArticle

Tong, SY, Lee, JM, Lee, JK, Kim, JW, Cho, CH, Kim, SM, Park, SY, Park, CY & Kim, KT 2011, 'Efficacy of para-aortic lymphadenectomy in early-stage endometrioid uterine corpus cancer', Annals of Surgical Oncology, vol. 18, no. 5, pp. 1425-1430. https://doi.org/10.1245/s10434-010-1472-7
Tong, Seo Yun ; Lee, Jong Min ; Lee, Jae Kwan ; Kim, Jae Weon ; Cho, Chi Heum ; Kim, Seok Mo ; Park, Sang Yoon ; Park, Chan Yong ; Kim, Ki Tae. / Efficacy of para-aortic lymphadenectomy in early-stage endometrioid uterine corpus cancer. In: Annals of Surgical Oncology. 2011 ; Vol. 18, No. 5. pp. 1425-1430.
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AU - Kim, Jae Weon

AU - Cho, Chi Heum

AU - Kim, Seok Mo

AU - Park, Sang Yoon

AU - Park, Chan Yong

AU - Kim, Ki Tae

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N2 - Purpose: The objective of this study was to assess whether para-aortic lymphadenectomy has therapeutic efficacy for patients with early-stage endometrioid uterine cancer who underwent systematic pelvic lymphadenectomy. Methods: The authors retrospectively reviewed the medical records and pathological findings of 547 patients with histologically proven FIGO stage I-II endometrioid uterine cancer, based on comprehensive surgical staging, including pelvic with or without para-aortic lymphadenectomy. Results: Among 547 patients, 330 patients had systematic pelvic lymphadenectomy only, and 217 had systematic pelvic with para-aortic lymphadenectomy. There were no significant differences in histopathological factors in the high-risk group, even though deep myometrial invasion (p = 0.02) and lymphvascular space invasion (p = 0.01) were more common in patients who underwent systematic pelvic with para-aortic lymphadenectomy in all study populations. Within a median follow-up of 31 (range, 5-120) months, there was no significant difference in overall survival between the pelvic lymphadenectomy only and pelvic with para-aortic lymphadenectomy groups in all populations (p = 0.77), even in high-risk patients (p = 0.82). Upon multivariate analysis, patients with lymphvascular space invasion had significantly worse overall survival (odds ratio (OR) = 7.38; 95% confidence interval (CI) = 1.86-29.23; p = 0.004). Conclusions: Although a prospective, randomized study needs to be performed for confirmation, our data suggest that the therapeutic benefit of para-aortic lymphadenectomy is uncertain in stage I and II endometrioid uterine corpus cancer, even in patients at high-risk for recurrence.

AB - Purpose: The objective of this study was to assess whether para-aortic lymphadenectomy has therapeutic efficacy for patients with early-stage endometrioid uterine cancer who underwent systematic pelvic lymphadenectomy. Methods: The authors retrospectively reviewed the medical records and pathological findings of 547 patients with histologically proven FIGO stage I-II endometrioid uterine cancer, based on comprehensive surgical staging, including pelvic with or without para-aortic lymphadenectomy. Results: Among 547 patients, 330 patients had systematic pelvic lymphadenectomy only, and 217 had systematic pelvic with para-aortic lymphadenectomy. There were no significant differences in histopathological factors in the high-risk group, even though deep myometrial invasion (p = 0.02) and lymphvascular space invasion (p = 0.01) were more common in patients who underwent systematic pelvic with para-aortic lymphadenectomy in all study populations. Within a median follow-up of 31 (range, 5-120) months, there was no significant difference in overall survival between the pelvic lymphadenectomy only and pelvic with para-aortic lymphadenectomy groups in all populations (p = 0.77), even in high-risk patients (p = 0.82). Upon multivariate analysis, patients with lymphvascular space invasion had significantly worse overall survival (odds ratio (OR) = 7.38; 95% confidence interval (CI) = 1.86-29.23; p = 0.004). Conclusions: Although a prospective, randomized study needs to be performed for confirmation, our data suggest that the therapeutic benefit of para-aortic lymphadenectomy is uncertain in stage I and II endometrioid uterine corpus cancer, even in patients at high-risk for recurrence.

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