Efficacy of sucralfate in the postoperative management of uvulopalatopharyngoplasty: A double-blind, randomized, controlled study

Prakash Zodpe, Jae-Gu Cho, Hee Joon Kang, Soon Jae Hwang, Heung Man Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To evaluate the effectiveness of sucralfate in influencing throat pain, otalgia, analgesic requirement, bleeding, mucosal recovery, and incidence of postoperative bleeding in patients undergoing uvulopalatopharyngoplasty. Design: A prospective double-blind randomized study. Setting: University-affiliated tertiary referral hospital. Participants: Eighty adult patients with obstructive sleep apnea syndrome requiring uvulopalatopharyngoplasty were recruited and randomly allocated into either a sucralfate treatment group or a control group. Interventions: All patients underwent uvulopalatopharyngoplasty. Patients enrolled in the sucralfate group (n=40) were instructed to gargle the sucralfate suspension and then to swallow. Patients enrolled in the control group (n=40) were instructed to gargle placebo suspension at the same doses and schedule. Main Outcome Measures: Postoperative throat pain, otalgia, amount of analgesic required, degree of strength (defined as patients' general well-being and return to regular daily activities), percentage of mucosal covering, and postoperative bleeding. Results: Throat pain and otalgia occurred significantly less often in sucralfate group, with less analgesic requirement and with rapid mucosal healing and early return to regular daily activities. There was no significant difference in episodes of postoperative bleeding between the 2 groups (P=.37). Conclusions: Although sucralfate therapy may not provide complete analgesia after uvulopalatopharyngoplasty, it may reduce the amount of analgesic required, thus preventing dose-related adverse effects from the analgesic agent. It can also significantly reduce the total number of days needed to return to normal daily activities (P=.41).

Original languageEnglish
Pages (from-to)1082-1085
Number of pages4
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume132
Issue number10
Publication statusPublished - 2006 Oct 25

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Sucralfate
Analgesics
Earache
Pharynx
Hemorrhage
Suspensions
Pain
Control Groups
Obstructive Sleep Apnea
Deglutition
Postoperative Pain
Double-Blind Method
Tertiary Care Centers
Analgesia
Appointments and Schedules
Placebos
Outcome Assessment (Health Care)
Incidence
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

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Efficacy of sucralfate in the postoperative management of uvulopalatopharyngoplasty : A double-blind, randomized, controlled study. / Zodpe, Prakash; Cho, Jae-Gu; Kang, Hee Joon; Hwang, Soon Jae; Lee, Heung Man.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 132, No. 10, 25.10.2006, p. 1082-1085.

Research output: Contribution to journalArticle

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abstract = "Objective: To evaluate the effectiveness of sucralfate in influencing throat pain, otalgia, analgesic requirement, bleeding, mucosal recovery, and incidence of postoperative bleeding in patients undergoing uvulopalatopharyngoplasty. Design: A prospective double-blind randomized study. Setting: University-affiliated tertiary referral hospital. Participants: Eighty adult patients with obstructive sleep apnea syndrome requiring uvulopalatopharyngoplasty were recruited and randomly allocated into either a sucralfate treatment group or a control group. Interventions: All patients underwent uvulopalatopharyngoplasty. Patients enrolled in the sucralfate group (n=40) were instructed to gargle the sucralfate suspension and then to swallow. Patients enrolled in the control group (n=40) were instructed to gargle placebo suspension at the same doses and schedule. Main Outcome Measures: Postoperative throat pain, otalgia, amount of analgesic required, degree of strength (defined as patients' general well-being and return to regular daily activities), percentage of mucosal covering, and postoperative bleeding. Results: Throat pain and otalgia occurred significantly less often in sucralfate group, with less analgesic requirement and with rapid mucosal healing and early return to regular daily activities. There was no significant difference in episodes of postoperative bleeding between the 2 groups (P=.37). Conclusions: Although sucralfate therapy may not provide complete analgesia after uvulopalatopharyngoplasty, it may reduce the amount of analgesic required, thus preventing dose-related adverse effects from the analgesic agent. It can also significantly reduce the total number of days needed to return to normal daily activities (P=.41).",
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