Efficacy of systematic pelvic lymphadenectomy in patients with non-endometrioid endometrial cancers: A retrospective, multicenter study in Korea

Seo Yun Tong, Jong Min Lee, Young Joon Choi, Jae Kwan Lee, Mi Kyung Kim, Chi Heum Cho, Seok Mo Kim, Sang Yoon Park, Chan Yong Park, Ki Tae Kim

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Aim: Non-endometrioid endometrial cancer is a clinically and pathologically distinct subtype of endometrial cancer. The aim of this study was to determine whether systematic pelvic lymphadenectomy improves overall survival compared to no lymphadenectomy in non-endometrioid endometrial cancer. Material and Methods: The authors retrospectively reviewed the medical records and pathological findings of 112 patients who underwent surgical staging for non-endometrioid endometrial cancer from 2000 to 2006 in Korea. Results: Systematic pelvic lymphadenectomy was performed in 71 patients. Pelvic lymph node metastases were identified in 31% and 14.6% patients who underwent systematic pelvic lymphadenectomy and no lymphadenectomy, respectively. After adjusting for risk factors, there was no significant difference in overall survival (odds ratio = 0.69; 95% confidence interval, 0.29-1.67) between patients who did or did not undergo systematic pelvic lymphadenectomy. On multivariate analysis, patients with lymph node metastasis had higher risk of death (odds ratio = 3.11; 95% confidence interval, 0.97-10.00) than the patients with no lymph node metastasis. Conclusion: Although systematic pelvic lymphadenectomy did not affect overall survival in patients with the non-endometrioid subtype, it has the potential benefit of providing prognostic information and acting as a guide for further adjuvant treatment.

Original languageEnglish
Pages (from-to)1321-1327
Number of pages7
JournalJournal of Obstetrics and Gynaecology Research
Volume38
Issue number11
DOIs
Publication statusPublished - 2012 Nov 1

Keywords

  • Endometrial neoplasm
  • Lymphadenectomy
  • Non-endometrioid
  • Prognosis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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