Efficacy of systematic pelvic lymphadenectomy in patients with non-endometrioid endometrial cancers

A retrospective, multicenter study in Korea

Seo Yun Tong, Jong Min Lee, Young Joon Choi, Jae Kwan Lee, Mi Kyung Kim, Chi Heum Cho, Seok Mo Kim, Sang Yoon Park, Chan Yong Park, Ki Tae Kim

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Aim: Non-endometrioid endometrial cancer is a clinically and pathologically distinct subtype of endometrial cancer. The aim of this study was to determine whether systematic pelvic lymphadenectomy improves overall survival compared to no lymphadenectomy in non-endometrioid endometrial cancer. Material and Methods: The authors retrospectively reviewed the medical records and pathological findings of 112 patients who underwent surgical staging for non-endometrioid endometrial cancer from 2000 to 2006 in Korea. Results: Systematic pelvic lymphadenectomy was performed in 71 patients. Pelvic lymph node metastases were identified in 31% and 14.6% patients who underwent systematic pelvic lymphadenectomy and no lymphadenectomy, respectively. After adjusting for risk factors, there was no significant difference in overall survival (odds ratio = 0.69; 95% confidence interval, 0.29-1.67) between patients who did or did not undergo systematic pelvic lymphadenectomy. On multivariate analysis, patients with lymph node metastasis had higher risk of death (odds ratio = 3.11; 95% confidence interval, 0.97-10.00) than the patients with no lymph node metastasis. Conclusion: Although systematic pelvic lymphadenectomy did not affect overall survival in patients with the non-endometrioid subtype, it has the potential benefit of providing prognostic information and acting as a guide for further adjuvant treatment.

Original languageEnglish
Pages (from-to)1321-1327
Number of pages7
JournalJournal of Obstetrics and Gynaecology Research
Volume38
Issue number11
DOIs
Publication statusPublished - 2012 Nov 1

Fingerprint

Endometrial Neoplasms
Korea
Lymph Node Excision
Multicenter Studies
Retrospective Studies
Lymph Nodes
Neoplasm Metastasis
Survival
Odds Ratio
Confidence Intervals
Medical Records
Multivariate Analysis

Keywords

  • Endometrial neoplasm
  • Lymphadenectomy
  • Non-endometrioid
  • Prognosis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Efficacy of systematic pelvic lymphadenectomy in patients with non-endometrioid endometrial cancers : A retrospective, multicenter study in Korea. / Tong, Seo Yun; Lee, Jong Min; Choi, Young Joon; Lee, Jae Kwan; Kim, Mi Kyung; Cho, Chi Heum; Kim, Seok Mo; Park, Sang Yoon; Park, Chan Yong; Kim, Ki Tae.

In: Journal of Obstetrics and Gynaecology Research, Vol. 38, No. 11, 01.11.2012, p. 1321-1327.

Research output: Contribution to journalReview article

Tong, Seo Yun ; Lee, Jong Min ; Choi, Young Joon ; Lee, Jae Kwan ; Kim, Mi Kyung ; Cho, Chi Heum ; Kim, Seok Mo ; Park, Sang Yoon ; Park, Chan Yong ; Kim, Ki Tae. / Efficacy of systematic pelvic lymphadenectomy in patients with non-endometrioid endometrial cancers : A retrospective, multicenter study in Korea. In: Journal of Obstetrics and Gynaecology Research. 2012 ; Vol. 38, No. 11. pp. 1321-1327.
@article{178d14cddcd2446b8b4711d94a10ab25,
title = "Efficacy of systematic pelvic lymphadenectomy in patients with non-endometrioid endometrial cancers: A retrospective, multicenter study in Korea",
abstract = "Aim: Non-endometrioid endometrial cancer is a clinically and pathologically distinct subtype of endometrial cancer. The aim of this study was to determine whether systematic pelvic lymphadenectomy improves overall survival compared to no lymphadenectomy in non-endometrioid endometrial cancer. Material and Methods: The authors retrospectively reviewed the medical records and pathological findings of 112 patients who underwent surgical staging for non-endometrioid endometrial cancer from 2000 to 2006 in Korea. Results: Systematic pelvic lymphadenectomy was performed in 71 patients. Pelvic lymph node metastases were identified in 31{\%} and 14.6{\%} patients who underwent systematic pelvic lymphadenectomy and no lymphadenectomy, respectively. After adjusting for risk factors, there was no significant difference in overall survival (odds ratio = 0.69; 95{\%} confidence interval, 0.29-1.67) between patients who did or did not undergo systematic pelvic lymphadenectomy. On multivariate analysis, patients with lymph node metastasis had higher risk of death (odds ratio = 3.11; 95{\%} confidence interval, 0.97-10.00) than the patients with no lymph node metastasis. Conclusion: Although systematic pelvic lymphadenectomy did not affect overall survival in patients with the non-endometrioid subtype, it has the potential benefit of providing prognostic information and acting as a guide for further adjuvant treatment.",
keywords = "Endometrial neoplasm, Lymphadenectomy, Non-endometrioid, Prognosis",
author = "Tong, {Seo Yun} and Lee, {Jong Min} and Choi, {Young Joon} and Lee, {Jae Kwan} and Kim, {Mi Kyung} and Cho, {Chi Heum} and Kim, {Seok Mo} and Park, {Sang Yoon} and Park, {Chan Yong} and Kim, {Ki Tae}",
year = "2012",
month = "11",
day = "1",
doi = "10.1111/j.1447-0756.2012.01875.x",
language = "English",
volume = "38",
pages = "1321--1327",
journal = "Journal of Obstetrics and Gynaecology Research",
issn = "1341-8076",
publisher = "Blackwell Publishing Asia",
number = "11",

}

TY - JOUR

T1 - Efficacy of systematic pelvic lymphadenectomy in patients with non-endometrioid endometrial cancers

T2 - A retrospective, multicenter study in Korea

AU - Tong, Seo Yun

AU - Lee, Jong Min

AU - Choi, Young Joon

AU - Lee, Jae Kwan

AU - Kim, Mi Kyung

AU - Cho, Chi Heum

AU - Kim, Seok Mo

AU - Park, Sang Yoon

AU - Park, Chan Yong

AU - Kim, Ki Tae

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Aim: Non-endometrioid endometrial cancer is a clinically and pathologically distinct subtype of endometrial cancer. The aim of this study was to determine whether systematic pelvic lymphadenectomy improves overall survival compared to no lymphadenectomy in non-endometrioid endometrial cancer. Material and Methods: The authors retrospectively reviewed the medical records and pathological findings of 112 patients who underwent surgical staging for non-endometrioid endometrial cancer from 2000 to 2006 in Korea. Results: Systematic pelvic lymphadenectomy was performed in 71 patients. Pelvic lymph node metastases were identified in 31% and 14.6% patients who underwent systematic pelvic lymphadenectomy and no lymphadenectomy, respectively. After adjusting for risk factors, there was no significant difference in overall survival (odds ratio = 0.69; 95% confidence interval, 0.29-1.67) between patients who did or did not undergo systematic pelvic lymphadenectomy. On multivariate analysis, patients with lymph node metastasis had higher risk of death (odds ratio = 3.11; 95% confidence interval, 0.97-10.00) than the patients with no lymph node metastasis. Conclusion: Although systematic pelvic lymphadenectomy did not affect overall survival in patients with the non-endometrioid subtype, it has the potential benefit of providing prognostic information and acting as a guide for further adjuvant treatment.

AB - Aim: Non-endometrioid endometrial cancer is a clinically and pathologically distinct subtype of endometrial cancer. The aim of this study was to determine whether systematic pelvic lymphadenectomy improves overall survival compared to no lymphadenectomy in non-endometrioid endometrial cancer. Material and Methods: The authors retrospectively reviewed the medical records and pathological findings of 112 patients who underwent surgical staging for non-endometrioid endometrial cancer from 2000 to 2006 in Korea. Results: Systematic pelvic lymphadenectomy was performed in 71 patients. Pelvic lymph node metastases were identified in 31% and 14.6% patients who underwent systematic pelvic lymphadenectomy and no lymphadenectomy, respectively. After adjusting for risk factors, there was no significant difference in overall survival (odds ratio = 0.69; 95% confidence interval, 0.29-1.67) between patients who did or did not undergo systematic pelvic lymphadenectomy. On multivariate analysis, patients with lymph node metastasis had higher risk of death (odds ratio = 3.11; 95% confidence interval, 0.97-10.00) than the patients with no lymph node metastasis. Conclusion: Although systematic pelvic lymphadenectomy did not affect overall survival in patients with the non-endometrioid subtype, it has the potential benefit of providing prognostic information and acting as a guide for further adjuvant treatment.

KW - Endometrial neoplasm

KW - Lymphadenectomy

KW - Non-endometrioid

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=84869185008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869185008&partnerID=8YFLogxK

U2 - 10.1111/j.1447-0756.2012.01875.x

DO - 10.1111/j.1447-0756.2012.01875.x

M3 - Review article

VL - 38

SP - 1321

EP - 1327

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

SN - 1341-8076

IS - 11

ER -