Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

Hee Joon Lee, Kyungho Park, Goun Bae, Jaehoon Choe, Kwang Ho Song, Sunwoo Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction.

Original languageEnglish
Pages (from-to)5064-5067
Number of pages4
JournalTetrahedron Letters
Volume52
Issue number39
DOIs
Publication statusPublished - 2011 Sep 28

Keywords

  • Decarboxylative coupling
  • Diaryl alkynes
  • Flow chemistry
  • Micromixer
  • Palladium

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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