Egr-1 expression induced by ZnO nanoparticles in human keratinocytes

Sang Hoon Jeong, Hwa Jung Ryu, Yoon Hee Park, Hyun Cheol Bae, Sang Wook Son

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Zinc oxide (ZnO) nanoparticles (NPs) are widely used in cosmetics and sunscreen. In spite of the broad application of ZnO NPs on human skin, there are limited literatures on the potential toxicities of ZnO NPs at the cellular and molecular levels. The aim of this study was to investigate the signaling pathways of ZnO NPs-induced early growth response-1 (Egr-1) expression and the role of Egr-1 in ZnO NPs-induced cytokine expression. ZnO NPs increased the Egr-1 expression, promoter activity and its nuclear translocation in HaCaT cells. ZnO NPs activated extracellular signal-regulated kinase (ERK) of mitogen-activated protein kinase (MAPK) pathways. Up-regulation of Egr-1 expression by ZnO NPs stimulation was found to be inhibited by an ERK inhibitor, but by neither c-Jun-N-terminal kinase (JNK) nor p38 inhibitor. Our results showed that ZnO NPs induces Egr-1 expression via MAPK pathway in human keratinocytes and cytokine expression by Egr-1. These pathways may contribute to NPs-induced cutaneous toxicity.

Original languageEnglish
Title of host publication2012 12th IEEE International Conference on Nanotechnology, NANO 2012
DOIs
Publication statusPublished - 2012 Nov 22
Event2012 12th IEEE International Conference on Nanotechnology, NANO 2012 - Birmingham, United Kingdom
Duration: 2012 Aug 202012 Aug 23

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Other

Other2012 12th IEEE International Conference on Nanotechnology, NANO 2012
CountryUnited Kingdom
CityBirmingham
Period12/8/2012/8/23

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Keywords

  • Egr-1
  • Nanotoxicity
  • ZnO nanoparticls

ASJC Scopus subject areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

Cite this

Jeong, S. H., Ryu, H. J., Park, Y. H., Bae, H. C., & Son, S. W. (2012). Egr-1 expression induced by ZnO nanoparticles in human keratinocytes. In 2012 12th IEEE International Conference on Nanotechnology, NANO 2012 [6321932] (Proceedings of the IEEE Conference on Nanotechnology). https://doi.org/10.1109/NANO.2012.6321932