Elastic, double-layered poly (l-lactide-co-Ïμ-caprolactone) scaffold for long-term vascular reconstruction

Cho Hay Mun, Sang Hoon Kim, Youngmee Jung, Sang Heon Kim, Ae Kyeong Kim, Dong Ik Kim, Soo Hyun Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Synthetic vessel grafts have been used as vascular substitutes for cardiovascular bypass procedures. In this study, we developed a novel tubular double-layered poly(l-lactide-co-Ïμ-caprolactone) scaffold that did not require pretreatment with cell seeding by promoting autologous tissue regeneration by inducing the proliferation and differentiation of endothelial and smooth muscle progenitor cells after implantation. The patency and mechanical properties were maintained for one year after implantation, although 95% of the poly(l-lactide-co-Ïμ-caprolactone) scaffolds had degraded. After this period, there was a lining of endothelial cells, an accumulation of collagen and elastin, and the development of neovascularization inside the poly(l-lactide-co-Ïμ-caprolactone).

Original languageEnglish
Pages (from-to)233-246
Number of pages14
JournalJournal of Bioactive and Compatible Polymers
Volume28
Issue number3
DOIs
Publication statusPublished - 2013 May
Externally publishedYes

Keywords

  • Poly(l-lactide-co-caprolactone) vascular graft without cells
  • cardiovascular bypass
  • elastomer
  • endothelial cell lining
  • neovascularization

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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