TY - JOUR
T1 - Electrical stimulation accelerates neurite regeneration in axotomized dorsal root ganglion neurons by increasing MMP-2 expression
AU - Han, Sungmin
AU - Kim, Dong Hwee
AU - Sung, Joohwan
AU - Yang, Hwasun
AU - Park, Jong Woong
AU - Youn, Inchan
N1 - Funding Information:
This research was supported in part by a grant the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (HI14C3477) and the National Research Council of Science & Technology grant by the Korea government (MSIT) (No. CAP-18-01-KIST).
Funding Information:
This research was supported in part by a grant the Korea Health Technology R&D Project through the Korea Health Industry Development Institute , funded by the Ministry of Health and Welfare, Republic of Korea ( HI14C3477 ) and the National Research Council of Science & Technology grant by the Korea government (MSIT) (No. CAP-18-01-KIST ).
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/1/8
Y1 - 2019/1/8
N2 - Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration. Our data suggest that the positive effect of ES on neurite regeneration could likely be mediated by an increase in MMP-2 expression, thereby promoting the regeneration of injured neurites.
AB - Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration. Our data suggest that the positive effect of ES on neurite regeneration could likely be mediated by an increase in MMP-2 expression, thereby promoting the regeneration of injured neurites.
KW - Dorsal root ganglion
KW - Electrical stimulation
KW - Matrix metalloproteinase
KW - Neurite regeneration
UR - http://www.scopus.com/inward/record.url?scp=85057274062&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2018.11.159
DO - 10.1016/j.bbrc.2018.11.159
M3 - Article
C2 - 30503336
AN - SCOPUS:85057274062
VL - 508
SP - 348
EP - 353
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -