Electrical stimulation inhibits cytosine arabinoside-induced neuronal death by preventing apoptosis in dorsal root ganglion neurons

Sungmin Han, Donghwee Kim, Hyungmin Kim, Jong Woong Park, Inchan Youn

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The current study aimed to investigate whether electrical stimulation could prevent apoptotic neuronal cell death during treatment with cytosine arabinoside (ara-C). From in-vitro experiments, the effects of electrical stimulation were assessed on neurite fragmentation and neuronal cell death in ara-C-treated dorsal root ganglion (DRG) explants. Ara-C treatment increased neurite fragmentation and neuronal cell death in DRG explants and activated caspase-3 by cleaving it, which could induce apoptosis. Electrical stimulation can significantly reduce neurite fragmentation and neuronal cell death compared with nonelectrically stimulated groups. Furthermore, electrical stimulation inhibited caspase-3 activation and reduced apoptotic neuronal death in DRG explants. It was suggested that the neuroprotective effect of electrical stimulation is likely mediated by the inhibition of caspase-3 activation and therefore the inhibition of apoptosis following ara-C treatment.

Original languageEnglish
Pages (from-to)1217-1224
Number of pages8
JournalNeuroreport
Volume27
Issue number16
DOIs
Publication statusPublished - 2016 Nov 1

Keywords

  • apoptotic neuronal death
  • dorsal root ganglion neuron
  • electrical stimulation
  • neurotoxicity

ASJC Scopus subject areas

  • Neuroscience(all)

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