Electrochemical aptamer-based biosensors

Yeon Seok Kim, Su Jin Lee, Man Bock Gu

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Aptamers are newly emerged sensing elements that are competitive with or sometimes even better than antibodies due to their various advantages: a compact size, cost effectiveness, chemical stability, in vitro synthesis, easy modification, labeling and so on. Therefore, there have recently been intensive advances in aptamer-based biosensors including electrochemical aptasensors that are more proper to the miniaturization and integration of biosensors for high-throughput analysis and point-of-care (POC). In this review, we have summarized new state of the art strategies for an aptamer-based electrochemical sensing platform and manners of signal amplification in the categories of simple label-free electrochemical detection, electrochemical signal amplification using enzymes or nanoparticles, target-induced conformational changes, and displacement formats.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalBiochip Journal
Volume2
Issue number3
Publication statusPublished - 2009

Keywords

  • Aptamer
  • Aptasensor
  • Biosensor
  • Electrochemical
  • Signal amplification

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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