Electrochemical aptamer-based biosensors

Yeon Seok Kim, Su Jin Lee, Man Bock Gu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aptamers are newly emerged sensing elements that are competitive with or sometimes even better than antibodies due to their various advantages: a compact size, cost effectiveness, chemical stability, in vitro synthesis, easy modification, labeling and so on. Therefore, there have recently been intensive advances in aptamer-based biosensors including electrochemical aptasensors that are more proper to the miniaturization and integration of biosensors for high-throughput analysis and point-of-care (POC). In this review, we have summarized new state of the art strategies for an aptamer-based electrochemical sensing platform and manners of signal amplification in the categories of simple label-free electrochemical detection, electrochemical signal amplification using enzymes or nanoparticles, target-induced conformational changes, and displacement formats.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalBiochip Journal
Volume2
Issue number3
Publication statusPublished - 2009 Nov 12

Fingerprint

Biosensing Techniques
Biosensors
Amplification
Point-of-Care Systems
Miniaturization
Chemical stability
Cost effectiveness
Antibodies
Nanoparticles
Labeling
Cost-Benefit Analysis
Labels
Enzymes
Throughput
In Vitro Techniques

Keywords

  • Aptamer
  • Aptasensor
  • Biosensor
  • Electrochemical
  • Signal amplification

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Kim, Y. S., Lee, S. J., & Gu, M. B. (2009). Electrochemical aptamer-based biosensors. Biochip Journal, 2(3), 175-182.

Electrochemical aptamer-based biosensors. / Kim, Yeon Seok; Lee, Su Jin; Gu, Man Bock.

In: Biochip Journal, Vol. 2, No. 3, 12.11.2009, p. 175-182.

Research output: Contribution to journalArticle

Kim, YS, Lee, SJ & Gu, MB 2009, 'Electrochemical aptamer-based biosensors', Biochip Journal, vol. 2, no. 3, pp. 175-182.
Kim YS, Lee SJ, Gu MB. Electrochemical aptamer-based biosensors. Biochip Journal. 2009 Nov 12;2(3):175-182.
Kim, Yeon Seok ; Lee, Su Jin ; Gu, Man Bock. / Electrochemical aptamer-based biosensors. In: Biochip Journal. 2009 ; Vol. 2, No. 3. pp. 175-182.
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