Electrochemical detection of DNA mutations on a PNA-modified electrode utilizing a single-stranded DNA specific endonuclease

Sujeong Shin, Byoung Yeon Won, Cheulhee Jung, Sung Chul Shin, Dae Yeon Cho, Soo Suk Lee, Hyun Gyu Park

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Utilizing a peptide nucleic acid (PNA)-modified electrode and a single-stranded DNA specific endonuclease, a novel electrochemical method to identify DNA mutations has been developed and represents a totally new strategy for the electrochemical diagnosis of human genetic mutations.

Original languageEnglish
Pages (from-to)6611-6613
Number of pages3
JournalChemical Communications
Volume47
Issue number23
DOIs
Publication statusPublished - 2011 Jun 21
Externally publishedYes

Fingerprint

Peptide Nucleic Acids
Endonucleases
Single-Stranded DNA
Deoxyribonuclease I
Electrodes
DNA
Mutation
Medical Genetics

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Electrochemical detection of DNA mutations on a PNA-modified electrode utilizing a single-stranded DNA specific endonuclease. / Shin, Sujeong; Won, Byoung Yeon; Jung, Cheulhee; Shin, Sung Chul; Cho, Dae Yeon; Lee, Soo Suk; Park, Hyun Gyu.

In: Chemical Communications, Vol. 47, No. 23, 21.06.2011, p. 6611-6613.

Research output: Contribution to journalArticle

Shin, Sujeong ; Won, Byoung Yeon ; Jung, Cheulhee ; Shin, Sung Chul ; Cho, Dae Yeon ; Lee, Soo Suk ; Park, Hyun Gyu. / Electrochemical detection of DNA mutations on a PNA-modified electrode utilizing a single-stranded DNA specific endonuclease. In: Chemical Communications. 2011 ; Vol. 47, No. 23. pp. 6611-6613.
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AU - Park, Hyun Gyu

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