Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes

Yang Rae Kim, Sungyool Bong, Yeon Joo Kang, Yongtak Yang, Rakesh Kumar Mahajan, Jong Seung Kim, Hasuck Kim

Research output: Contribution to journalArticle

496 Citations (Scopus)

Abstract

Dopamine plays a significant role in the function of human metabolism. It is important to develop sensitive sensor for the determination of dopamine without the interference by ascorbic acid. This paper reports the synthesis of graphene using a modified Hummer's method and its application for the electrochemical detection of dopamine. Electrochemical measurements were performed at glassy carbon electrode modified with graphene via drop-casting method. Cyclic voltammogram of ferri/ferrocyanide redox couple at graphene modified electrode showed an increased current intensity compared with glassy carbon electrode and graphite modified electrode. The decrease of charge transfer resistance was also analyzed by electrochemical impedance spectroscopy. The capacity of graphene modified electrode for selective detection of dopamine was confirmed in a sufficient amount of ascorbic acid (1. mM). The observed linear range for the determination of dopamine concentration was from 4μM to 100μM. The detection limit was estimated to be 2.64μM.

Original languageEnglish
Pages (from-to)2366-2369
Number of pages4
JournalBiosensors and Bioelectronics
Volume25
Issue number10
DOIs
Publication statusPublished - 2010 Jun 1

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Graphite
Ascorbic acid
Graphene
Ascorbic Acid
Dopamine
Electrodes
Glassy carbon
Carbon
Dielectric Spectroscopy
Electrochemical impedance spectroscopy
Metabolism
Oxidation-Reduction
Limit of Detection
Charge transfer
Casting
Sensors

Keywords

  • Ascorbic acid
  • Cyclic voltammetry
  • Dopamine
  • Electrochemical impedance spectroscopy
  • Graphene

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Biotechnology
  • Electrochemistry

Cite this

Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes. / Kim, Yang Rae; Bong, Sungyool; Kang, Yeon Joo; Yang, Yongtak; Mahajan, Rakesh Kumar; Kim, Jong Seung; Kim, Hasuck.

In: Biosensors and Bioelectronics, Vol. 25, No. 10, 01.06.2010, p. 2366-2369.

Research output: Contribution to journalArticle

Kim, Yang Rae ; Bong, Sungyool ; Kang, Yeon Joo ; Yang, Yongtak ; Mahajan, Rakesh Kumar ; Kim, Jong Seung ; Kim, Hasuck. / Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes. In: Biosensors and Bioelectronics. 2010 ; Vol. 25, No. 10. pp. 2366-2369.
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