Electrochemical serotonin monitoring of poly(ethylenedioxythiophene)

Poly(sodium 4-styrenesulfonate)-modified fluorine-doped tin oxide by predeposition of self-assembled 4-pyridylporphyrin

Min Jung Song, Sangsig Kim, Nam Ki Min, Joon Hyung Jin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A 5,10,15,20-tetrakis(4-pyridyl)-21. H,23. H-porphyrin (TPyP)-modified self-assembled functional layer was prepared on a fluorine-doped tin oxide (FTO) substrate. We employed a bifunctional molecule, 3-iodopropionate (3IP), to covalently bind TPyP to the FTO substrate. The 3IP-monolayered FTO and the TPyP-3IP-bilayered FTO electrodes were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and Fourier transform-infrared spectroscopy. Compared to conventional electropolymerized poly(ethylenedioxythiophene):poly(sodium 4-styrenesulfonate) (PEDOT:PSS) film on bare FTO, the PEDOT:PSS film on the TPyP-3IP-bilayered FTO showed better sensitivity and selectivity in monitoring serotonin in the presence of high concentrations of interfering agents such as ascorbic acid, urea, d-(+)-glucose, epinephrine, and l-3,4-dihydroxyphenylalanine. Both PEDOT:PSS films on the bare FTO and the TPyP-3IP-bilayered FTO showed electrocatalytic effects in serotonin detection, and only the TPyP-3IP-based PEDOT:PSS film acted as a pH resistant buffer layer in the selective detection of serotonin.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalBiosensors and Bioelectronics
Volume52
DOIs
Publication statusPublished - 2014 Feb 15

Fingerprint

Fluorine
Tin oxides
Serotonin
Sodium
Monitoring
Dielectric Spectroscopy
Dihydroxyphenylalanine
styrenesulfonic acid polymer
stannic oxide
Ascorbic acid
Porphyrins
Fourier Transform Infrared Spectroscopy
Substrates
Buffer layers
Electrochemical impedance spectroscopy
Urea
Epinephrine
Ascorbic Acid
Cyclic voltammetry
Fourier transform infrared spectroscopy

Keywords

  • 5,10,15,20-tetrakis(4-pyridyl)-21H23H-porphyrin
  • Binary self-assembled monolayer
  • Cyclic voltammetry
  • Electrochemical impedance spectroscopy
  • PEDOT:PSS
  • Serotonin

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Biotechnology
  • Electrochemistry

Cite this

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title = "Electrochemical serotonin monitoring of poly(ethylenedioxythiophene): Poly(sodium 4-styrenesulfonate)-modified fluorine-doped tin oxide by predeposition of self-assembled 4-pyridylporphyrin",
abstract = "A 5,10,15,20-tetrakis(4-pyridyl)-21. H,23. H-porphyrin (TPyP)-modified self-assembled functional layer was prepared on a fluorine-doped tin oxide (FTO) substrate. We employed a bifunctional molecule, 3-iodopropionate (3IP), to covalently bind TPyP to the FTO substrate. The 3IP-monolayered FTO and the TPyP-3IP-bilayered FTO electrodes were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and Fourier transform-infrared spectroscopy. Compared to conventional electropolymerized poly(ethylenedioxythiophene):poly(sodium 4-styrenesulfonate) (PEDOT:PSS) film on bare FTO, the PEDOT:PSS film on the TPyP-3IP-bilayered FTO showed better sensitivity and selectivity in monitoring serotonin in the presence of high concentrations of interfering agents such as ascorbic acid, urea, d-(+)-glucose, epinephrine, and l-3,4-dihydroxyphenylalanine. Both PEDOT:PSS films on the bare FTO and the TPyP-3IP-bilayered FTO showed electrocatalytic effects in serotonin detection, and only the TPyP-3IP-based PEDOT:PSS film acted as a pH resistant buffer layer in the selective detection of serotonin.",
keywords = "5,10,15,20-tetrakis(4-pyridyl)-21H23H-porphyrin, Binary self-assembled monolayer, Cyclic voltammetry, Electrochemical impedance spectroscopy, PEDOT:PSS, Serotonin",
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T1 - Electrochemical serotonin monitoring of poly(ethylenedioxythiophene)

T2 - Poly(sodium 4-styrenesulfonate)-modified fluorine-doped tin oxide by predeposition of self-assembled 4-pyridylporphyrin

AU - Song, Min Jung

AU - Kim, Sangsig

AU - Ki Min, Nam

AU - Jin, Joon Hyung

PY - 2014/2/15

Y1 - 2014/2/15

N2 - A 5,10,15,20-tetrakis(4-pyridyl)-21. H,23. H-porphyrin (TPyP)-modified self-assembled functional layer was prepared on a fluorine-doped tin oxide (FTO) substrate. We employed a bifunctional molecule, 3-iodopropionate (3IP), to covalently bind TPyP to the FTO substrate. The 3IP-monolayered FTO and the TPyP-3IP-bilayered FTO electrodes were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and Fourier transform-infrared spectroscopy. Compared to conventional electropolymerized poly(ethylenedioxythiophene):poly(sodium 4-styrenesulfonate) (PEDOT:PSS) film on bare FTO, the PEDOT:PSS film on the TPyP-3IP-bilayered FTO showed better sensitivity and selectivity in monitoring serotonin in the presence of high concentrations of interfering agents such as ascorbic acid, urea, d-(+)-glucose, epinephrine, and l-3,4-dihydroxyphenylalanine. Both PEDOT:PSS films on the bare FTO and the TPyP-3IP-bilayered FTO showed electrocatalytic effects in serotonin detection, and only the TPyP-3IP-based PEDOT:PSS film acted as a pH resistant buffer layer in the selective detection of serotonin.

AB - A 5,10,15,20-tetrakis(4-pyridyl)-21. H,23. H-porphyrin (TPyP)-modified self-assembled functional layer was prepared on a fluorine-doped tin oxide (FTO) substrate. We employed a bifunctional molecule, 3-iodopropionate (3IP), to covalently bind TPyP to the FTO substrate. The 3IP-monolayered FTO and the TPyP-3IP-bilayered FTO electrodes were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and Fourier transform-infrared spectroscopy. Compared to conventional electropolymerized poly(ethylenedioxythiophene):poly(sodium 4-styrenesulfonate) (PEDOT:PSS) film on bare FTO, the PEDOT:PSS film on the TPyP-3IP-bilayered FTO showed better sensitivity and selectivity in monitoring serotonin in the presence of high concentrations of interfering agents such as ascorbic acid, urea, d-(+)-glucose, epinephrine, and l-3,4-dihydroxyphenylalanine. Both PEDOT:PSS films on the bare FTO and the TPyP-3IP-bilayered FTO showed electrocatalytic effects in serotonin detection, and only the TPyP-3IP-based PEDOT:PSS film acted as a pH resistant buffer layer in the selective detection of serotonin.

KW - 5,10,15,20-tetrakis(4-pyridyl)-21H23H-porphyrin

KW - Binary self-assembled monolayer

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KW - Electrochemical impedance spectroscopy

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