Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus

Hyun Kim, Jae Pil Ko, Ung Gu Kang, Joo Bae Park, Hyung Lae Kim, Young Han Lee, Yong Sik Kim

Research output: Contribution to journalArticle

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Abstract

We investigated the expression of inositol 1,4,5-trisphosphate (InsP3) 3- kinase mRNA after a single electroconvulsive shock (ECS) with in situ hybridization histochemistry in rat brain. At 6 h after ECS, the expression was markedly decreased in the dentate gyrus, and the decrease was maintained until 9 h with a slight recovery. The InsP3 3-kinase mRNA content returned to basal levels after 12 h. We could not detect any apparent changes in the expression of InsP3 3-kinase mRNA in the CA1-CA3 areas of hippocampus, the striatum, and the cerebral cortex at any time point examined. In the temporal pattern, the reduction of the expression in the dentate gyrus was preceded by the induction of c-fos after ECS. These observations suggest that the InsP3 3-kinase might be one of the genes whose expression can be altered by ECS.

Original languageEnglish
Pages (from-to)1991-1994
Number of pages4
JournalJournal of Neurochemistry
Volume63
Issue number5
Publication statusPublished - 1994 Nov 1

Fingerprint

Inositol 1,4,5-trisphosphate 3-kinase
Electroshock
Dentate Gyrus
Rats
Phosphotransferases
Messenger RNA
Inositol 1,4,5-Trisphosphate
Gene expression
Cerebral Cortex
In Situ Hybridization
Hippocampus
Brain
Gene Expression
Recovery

Keywords

  • c-fos
  • Dentate gyrus
  • Electroconvulsive shock
  • In situ hybridization histochemistry
  • Inositol 1,4,5- trisphosphate 3-kinase

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Kim, H., Ko, J. P., Kang, U. G., Park, J. B., Kim, H. L., Lee, Y. H., & Kim, Y. S. (1994). Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus. Journal of Neurochemistry, 63(5), 1991-1994.

Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus. / Kim, Hyun; Ko, Jae Pil; Kang, Ung Gu; Park, Joo Bae; Kim, Hyung Lae; Lee, Young Han; Kim, Yong Sik.

In: Journal of Neurochemistry, Vol. 63, No. 5, 01.11.1994, p. 1991-1994.

Research output: Contribution to journalArticle

Kim, H, Ko, JP, Kang, UG, Park, JB, Kim, HL, Lee, YH & Kim, YS 1994, 'Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus', Journal of Neurochemistry, vol. 63, no. 5, pp. 1991-1994.
Kim, Hyun ; Ko, Jae Pil ; Kang, Ung Gu ; Park, Joo Bae ; Kim, Hyung Lae ; Lee, Young Han ; Kim, Yong Sik. / Electroconvulsive shock reduces inositol 1,4,5-trisphosphate 3-kinase mRNA expression in rat dentate gyrus. In: Journal of Neurochemistry. 1994 ; Vol. 63, No. 5. pp. 1991-1994.
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