Electroconvulsive shock reduces inositol trisphosphate receptor1 mRNA in rat brain

Hyun Kim, Im Joo Rhyu, Chang Mee Kim, Young Suk Suh, Joo Bae Park, Ung Gu Kang, Yong Sik Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We studied the expression pattern of the inositol 1,4,5-trisphosphate receptor1 (InsP3R1) mRNA after a single electroconvulsive shock (ECS) in the rat brain by in situ hybridization. The expression was significantly decreased in the dentate gyrus and the CA1 area of the hippocampal formation 3 to 24 h after ECS. While the downregulation of InsP3R1 by accelerated protein degradation has been reported, our results indicate that the downregulation of InsP3R1 occurs at the mRNA level. This finding, along with our previous report on the InsP3 3-kinase(A), suggests that ECS regulates the phosphoinositide mediated signaling, which might be related to the therapeutic mechanism of ECS.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalMolecules and Cells
Volume12
Issue number2
Publication statusPublished - 2001 Oct 31

Fingerprint

Electroshock
Inositol
Messenger RNA
Inositol 1,4,5-trisphosphate 3-kinase
Brain
Down-Regulation
Inositol 1,4,5-Trisphosphate
Dentate Gyrus
Phosphatidylinositols
Proteolysis
In Situ Hybridization
Hippocampus
Therapeutics

Keywords

  • Ca
  • Downregulation
  • Electroconvulsive Shock
  • Hippocampus
  • Inositol 1,4,5-Trisphosphate
  • Inositol 1,4,5-Trisphosphate Type 1 Receptor

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

Kim, H., Rhyu, I. J., Kim, C. M., Suh, Y. S., Park, J. B., Kang, U. G., & Kim, Y. S. (2001). Electroconvulsive shock reduces inositol trisphosphate receptor1 mRNA in rat brain. Molecules and Cells, 12(2), 173-177.

Electroconvulsive shock reduces inositol trisphosphate receptor1 mRNA in rat brain. / Kim, Hyun; Rhyu, Im Joo; Kim, Chang Mee; Suh, Young Suk; Park, Joo Bae; Kang, Ung Gu; Kim, Yong Sik.

In: Molecules and Cells, Vol. 12, No. 2, 31.10.2001, p. 173-177.

Research output: Contribution to journalArticle

Kim, H, Rhyu, IJ, Kim, CM, Suh, YS, Park, JB, Kang, UG & Kim, YS 2001, 'Electroconvulsive shock reduces inositol trisphosphate receptor1 mRNA in rat brain', Molecules and Cells, vol. 12, no. 2, pp. 173-177.
Kim, Hyun ; Rhyu, Im Joo ; Kim, Chang Mee ; Suh, Young Suk ; Park, Joo Bae ; Kang, Ung Gu ; Kim, Yong Sik. / Electroconvulsive shock reduces inositol trisphosphate receptor1 mRNA in rat brain. In: Molecules and Cells. 2001 ; Vol. 12, No. 2. pp. 173-177.
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