Electron microscopic evaluation of adhesion of Helicobacter pylori to the gastric epithelial cells in chronic gastritis.

Hoon Jai Chun, Dong Kyu Park, Chul Hee Park, Jae Hong Park, Yoon Tae Jeen, Soon Ho Um, Sang Wo Lee, Jai Hyun Choi, Chang Duck Kim, Ho Sang Ryu, Jin Hai Hyun, Yang Seok Chae, Chang Sub Uhm

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8 Citations (Scopus)

Abstract

BACKGROUND: The adhesion of H. pylori to the gastric epithelial cells may be an essential step for the pathophysiology of various H. pylori-induced gastrointestinal diseases. The purpose of this study was to investigate the ultrastructural relation of H. pylori and gastric epithelial cells in their adhesion. METHODS: Endoscopic biopsy of gastric antrum and body was performed from 15 patients (9 men, 6 women) with chronic gastritis and H. pylori infection. The specimens were processed for electron microscopy and observed with a transmission electron microscope (Hitachi H-600). RESULTS: On the basis of morphological appearances, the adhesions of H. pylori to the gastric epithelial cells were categorized into three types; filamentous connection, adhesion pedestals and membrane fusion. Coccoid and undetermined forms adhered mainly by the filamentous connection, whereas the bacillary forms adhered primarily by the adhesion pedestals and membrane fusion. CONCLUSION: Various types of adhesion were associated with H. pylori and gastric epithelium. Further studies are needed to evaluate the influence of different types of adhesion to the pathophysiology of H. pylori.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalThe Korean journal of internal medicine
Volume17
Issue number1
DOIs
Publication statusPublished - 2002 Mar

ASJC Scopus subject areas

  • Internal Medicine

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    Chun, H. J., Park, D. K., Park, C. H., Park, J. H., Jeen, Y. T., Um, S. H., Lee, S. W., Choi, J. H., Kim, C. D., Ryu, H. S., Hyun, J. H., Chae, Y. S., & Uhm, C. S. (2002). Electron microscopic evaluation of adhesion of Helicobacter pylori to the gastric epithelial cells in chronic gastritis. The Korean journal of internal medicine, 17(1), 45-50. https://doi.org/10.3904/kjim.2002.17.1.45