Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat

Yang In Kim, Si Hyun Kim, Do Young Kim, Hyang Woon Lee, Hyung Chul Shin, Jun Mo Chung, Hee Chul Han, Heung Sik Na, Seung Kil Hong

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The retinohypothalamic tract (RHT) is a neural pathway through which photic time cues are delivered directly to the mammalian circadian pacemaker in the suprachiasmatic nucleus (SCN). Although the excitatory amino acid glutamate is the primary neurotransmitter in the RHT, other substances such as substance P (SP) also have been suggested to play a role. The present study tested the hypothesis that SP participates in retinohypothalamic transmission and selectively modulates either N-methyl-D-aspartate (NMDA) or non-NMDA receptor-mediated neurotransmission. The SP antagonist L-703,606 depressed the excitatory postsynaptic current (EPSC) evoked by optic nerve stimulation in SCN neurons in rat hypothalamic slices. The SP antagonist also had a similar depressive effect on the NMDA and non-NMDA receptor-mediated components of the EPSC. These results suggest that SP is an excitatory neuromodulator contributing to the expression of both the NMDA and non-NMDA receptor-mediated components of retinohypothalamic transmission. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalNeuroscience Letters
Volume274
Issue number2
DOIs
Publication statusPublished - 1999 Oct 22

Fingerprint

Substance P
D-Aspartic Acid
N-Methylaspartate
Suprachiasmatic Nucleus
Excitatory Postsynaptic Potentials
L 703606
Neurotransmitter Agents
Neural Pathways
Excitatory Amino Acids
Optic Nerve
Synaptic Transmission
Cues
Glutamic Acid
Neurons
aspartic acid receptor

Keywords

  • Circadian rhythm
  • Electrophysiology
  • Neuromodulator
  • Neurotransmitter
  • Retinohypothalamic transmission
  • Substance P
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat. / Kim, Yang In; Kim, Si Hyun; Kim, Do Young; Lee, Hyang Woon; Shin, Hyung Chul; Chung, Jun Mo; Han, Hee Chul; Na, Heung Sik; Hong, Seung Kil.

In: Neuroscience Letters, Vol. 274, No. 2, 22.10.1999, p. 99-102.

Research output: Contribution to journalArticle

Kim, Yang In ; Kim, Si Hyun ; Kim, Do Young ; Lee, Hyang Woon ; Shin, Hyung Chul ; Chung, Jun Mo ; Han, Hee Chul ; Na, Heung Sik ; Hong, Seung Kil. / Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat. In: Neuroscience Letters. 1999 ; Vol. 274, No. 2. pp. 99-102.
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