Abstract
Cells and extracellular matrix (ECM) fibrils in most natural tissues are not random, but exhibit well-defined patterns and specific spatial orientation. Recent findings demonstrated that oriented biopolymer-based nanofibrous scaffolds have the potential for engineering blood vessels [1], neural tissue [2], and ligament tissue [3]. Furthermore, it has been shown that cell adhesion and proliferation [1] is significantly improved on oriented nanofibrous scaffolds. The contact guidance theory suggests that cells have the greatest probability of migrating in preferred orientations which are associated with chemical, structural, and=or mechanical properties of the substrate [4-6]. Consequently, it may be postulated that an oriented nanofibrous scaffold would guide cell alignment along the nanofibers. The cell arrangement onto an oriented nanofibrous scaffold could be due to the contact guidance and=or to cytoskeletal reorganization. Aligned cells could then be used to remodel and modulate the regenerated ECM and microenvironment [7].
| Original language | English |
|---|---|
| Title of host publication | Nanotechnology and Tissue Engineering |
| Subtitle of host publication | The Scaffold |
| Publisher | CRC Press |
| Pages | 243-260 |
| Number of pages | 18 |
| ISBN (Electronic) | 9781420051834 |
| ISBN (Print) | 9781420051827 |
| Publication status | Published - 2008 Jan 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Materials Science(all)
Cite this
Electrospinning techniques to control deposition and structural alignment of nanofibrous scaffolds for cellular orientation and cytoskeletal reorganization. / Wise, Joel K.; Cho, Michael; Zussman, Eyal; Megaridis, Constantine M.; Yarin, Alexander.
Nanotechnology and Tissue Engineering: The Scaffold. CRC Press, 2008. p. 243-260.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Electrospinning techniques to control deposition and structural alignment of nanofibrous scaffolds for cellular orientation and cytoskeletal reorganization
AU - Wise, Joel K.
AU - Cho, Michael
AU - Zussman, Eyal
AU - Megaridis, Constantine M.
AU - Yarin, Alexander
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Cells and extracellular matrix (ECM) fibrils in most natural tissues are not random, but exhibit well-defined patterns and specific spatial orientation. Recent findings demonstrated that oriented biopolymer-based nanofibrous scaffolds have the potential for engineering blood vessels [1], neural tissue [2], and ligament tissue [3]. Furthermore, it has been shown that cell adhesion and proliferation [1] is significantly improved on oriented nanofibrous scaffolds. The contact guidance theory suggests that cells have the greatest probability of migrating in preferred orientations which are associated with chemical, structural, and=or mechanical properties of the substrate [4-6]. Consequently, it may be postulated that an oriented nanofibrous scaffold would guide cell alignment along the nanofibers. The cell arrangement onto an oriented nanofibrous scaffold could be due to the contact guidance and=or to cytoskeletal reorganization. Aligned cells could then be used to remodel and modulate the regenerated ECM and microenvironment [7].
AB - Cells and extracellular matrix (ECM) fibrils in most natural tissues are not random, but exhibit well-defined patterns and specific spatial orientation. Recent findings demonstrated that oriented biopolymer-based nanofibrous scaffolds have the potential for engineering blood vessels [1], neural tissue [2], and ligament tissue [3]. Furthermore, it has been shown that cell adhesion and proliferation [1] is significantly improved on oriented nanofibrous scaffolds. The contact guidance theory suggests that cells have the greatest probability of migrating in preferred orientations which are associated with chemical, structural, and=or mechanical properties of the substrate [4-6]. Consequently, it may be postulated that an oriented nanofibrous scaffold would guide cell alignment along the nanofibers. The cell arrangement onto an oriented nanofibrous scaffold could be due to the contact guidance and=or to cytoskeletal reorganization. Aligned cells could then be used to remodel and modulate the regenerated ECM and microenvironment [7].
UR - http://www.scopus.com/inward/record.url?scp=80051933317&partnerID=8YFLogxK
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M3 - Chapter
SN - 9781420051827
SP - 243
EP - 260
BT - Nanotechnology and Tissue Engineering
PB - CRC Press
ER -