Electrostatic and hydrophobic interactions of lipid-associated α-synuclein: The role of a water-limited interfaces in amyloid fibrillation

Tae Su Choi, Jong Yoon Han, Chae Eun Heo, Sun Woo Lee, Hugh I. Kim

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Human α‑synuclein (αSyn) is an intrinsically disordered protein (IDP) whose biological and pathological functions in brain neuronal cells have not yet been fully elucidated. αSyn intrinsically participates in aiding neurotransmitter trafficking through αSyn the association with lipid membranes. However, lipid-associated states of αSyn also induce amyloid self-assembly that is linked to the pathogenesis of various synucleinopathies. These contradicting actions arise from the limited water content near lipid-water interfaces that controls αSyn electrostatic and hydrophobic interactions. Thus, understanding the molecular interactions between αSyn and lipid membranes in the presence of water molecules is critical in elucidating the pivotal role of lipid-associated αSyn in amyloid self-assembly. In this review, we describe how the membrane interface controls electrostatic and hydrophobic interactions of lipid-associated αSyn. Moreover, membrane amyloid self-assembly of αSyn will be further discussed with regards to the structural dynamics of lipid-associated αSyn and water molecules near the interface.

Original languageEnglish
Pages (from-to)1854-1862
Number of pages9
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1860
Issue number9
DOIs
Publication statusPublished - 2018 Sep 1

Fingerprint

Synucleins
Static Electricity
Hydrophobic and Hydrophilic Interactions
Amyloid
Electrostatics
Lipids
Water
Self assembly
Membrane Lipids
Intrinsically Disordered Proteins
Membranes
Molecules
Molecular interactions
Structural dynamics
Water content
Neurotransmitter Agents
Brain

Keywords

  • Amyloid fibrillation
  • Electrostatic and hydrophobic interactions
  • Intrinsically disordered protein structures
  • Lipid membrane-water interface
  • Lipid-associated α‑synuclein
  • Water-limited environment

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

Electrostatic and hydrophobic interactions of lipid-associated α-synuclein : The role of a water-limited interfaces in amyloid fibrillation. / Choi, Tae Su; Han, Jong Yoon; Heo, Chae Eun; Lee, Sun Woo; Kim, Hugh I.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1860, No. 9, 01.09.2018, p. 1854-1862.

Research output: Contribution to journalReview article

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AU - Lee, Sun Woo

AU - Kim, Hugh I.

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